FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984091569> ?p ?o ?g. }

• W1984091569 endingPage "1717" @default.
• W1984091569 startingPage "1709" @default.
• W1984091569 abstract "Summary THC decreases edema more in male rats but is more effective against inflammatory pain in females. Sex differences in THC's peripheral effects against inflammatory pain may be a result of activation of CB1 and CB2 receptors in females, in contrast to primarily CB1 receptors in males. Cannabinoid agonists such as Δ9-tetrahydrocannabinol (THC) are more potent and/or efficacious antinociceptive agents in female than male rats using acute pain models. We tested the hypothesis that THC is more effective in females than males using a model of longer-lasting, inflammatory pain. THC's anti-allodynic, anti-hyperalgesic, and anti-edema effects were examined 1, 3, and 7 days after injection of complete Freund's adjuvant (CFA) into the hind paw. Systemically administered THC (0.32–3.2 mg/kg, intraperitoneally [i.p.], same dose each day) was significantly more effective in females than males in attenuating CFA-induced thermal hyperalgesia, but was also more sedative in females. When administered locally into the inflamed hind paw, THC (250–500 μg intraplantar, i.pl.) did not affect locomotor activity in either sex, yet produced greater anti-allodynic and anti-hyperalgesic effects in females than males. Despite THC's greater anti-allodynic and anti-hyperalgesic effects in females, both i.p. and i.pl. THC reduced hind paw thickness (edema) more in males. The anti-hyperalgesic effect of i.p. THC was blocked by the CB1 receptor-selective antagonist rimonabant in both sexes. Similarly, i.pl. rimonabant antagonized i.pl. THC's effects in both sexes; in contrast, the CB2 antagonist SR144528 significantly attenuated i.pl. THC's anti-allodynic effect only in females. Intraplantar SR144528 also antagonized i.pl. THC's anti-edema effect in males. This study suggests that cannabinoids may be better at reducing edema in males while being more effective against inflammatory pain in females. Furthermore, sex differences in THC's peripheral effects against inflammatory pain may be a result of activation of both types of cannabinoid receptors in females, in contrast to predominantly CB1 receptors in males." @default.
• W1984091569 created "2016-06-24" @default.
• W1984091569 creator A5041895158 @default.
• W1984091569 creator A5057230923 @default.
• W1984091569 creator A5069877732 @default.
• W1984091569 date "2013-09-01" @default.
• W1984091569 modified "2023-10-11" @default.
• W1984091569 title "Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat" @default.
• W1984091569 cites W1566727921 @default.
• W1984091569 cites W1666625984 @default.
• W1984091569 cites W1959296941 @default.
• W1984091569 cites W1970396762 @default.
• W1984091569 cites W1982029344 @default.
• W1984091569 cites W1991319303 @default.
• W1984091569 cites W1998393571 @default.
• W1984091569 cites W2003289143 @default.
• W1984091569 cites W2003640068 @default.
• W1984091569 cites W2015042310 @default.
• W1984091569 cites W2024424770 @default.
• W1984091569 cites W2032416963 @default.
• W1984091569 cites W2036323596 @default.
• W1984091569 cites W2053866365 @default.
• W1984091569 cites W2056739748 @default.
• W1984091569 cites W2058262364 @default.
• W1984091569 cites W2060968549 @default.
• W1984091569 cites W2061176386 @default.
• W1984091569 cites W2061954127 @default.
• W1984091569 cites W2064907044 @default.
• W1984091569 cites W2067408354 @default.
• W1984091569 cites W2080973991 @default.
• W1984091569 cites W2081009152 @default.
• W1984091569 cites W2085482915 @default.
• W1984091569 cites W2098443650 @default.
• W1984091569 cites W2101631514 @default.
• W1984091569 cites W2133784348 @default.
• W1984091569 cites W2143228770 @default.
• W1984091569 cites W2158383438 @default.
• W1984091569 cites W2161820607 @default.
• W1984091569 cites W89713122 @default.
• W1984091569 doi "https://doi.org/10.1016/j.pain.2013.05.017" @default.
• W1984091569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23707295" @default.
• W1984091569 hasPublicationYear "2013" @default.
• W1984091569 type Work @default.
• W1984091569 sameAs 1984091569 @default.
• W1984091569 citedByCount "55" @default.
• W1984091569 countsByYear W19840915692013 @default.
• W1984091569 countsByYear W19840915692014 @default.
• W1984091569 countsByYear W19840915692015 @default.
• W1984091569 countsByYear W19840915692016 @default.
• W1984091569 countsByYear W19840915692017 @default.
• W1984091569 countsByYear W19840915692018 @default.
• W1984091569 countsByYear W19840915692019 @default.
• W1984091569 countsByYear W19840915692020 @default.
• W1984091569 countsByYear W19840915692021 @default.
• W1984091569 countsByYear W19840915692022 @default.
• W1984091569 countsByYear W19840915692023 @default.
• W1984091569 crossrefType "journal-article" @default.
• W1984091569 hasAuthorship W1984091569A5041895158 @default.
• W1984091569 hasAuthorship W1984091569A5057230923 @default.
• W1984091569 hasAuthorship W1984091569A5069877732 @default.
• W1984091569 hasConcept C126322002 @default.
• W1984091569 hasConcept C148001335 @default.
• W1984091569 hasConcept C15490471 @default.
• W1984091569 hasConcept C170493617 @default.
• W1984091569 hasConcept C2776433454 @default.
• W1984091569 hasConcept C2776885963 @default.
• W1984091569 hasConcept C2779245659 @default.
• W1984091569 hasConcept C2780871563 @default.
• W1984091569 hasConcept C2780886150 @default.
• W1984091569 hasConcept C42219234 @default.
• W1984091569 hasConcept C71924100 @default.
• W1984091569 hasConcept C98274493 @default.
• W1984091569 hasConceptScore W1984091569C126322002 @default.
• W1984091569 hasConceptScore W1984091569C148001335 @default.
• W1984091569 hasConceptScore W1984091569C15490471 @default.
• W1984091569 hasConceptScore W1984091569C170493617 @default.
• W1984091569 hasConceptScore W1984091569C2776433454 @default.
• W1984091569 hasConceptScore W1984091569C2776885963 @default.
• W1984091569 hasConceptScore W1984091569C2779245659 @default.
• W1984091569 hasConceptScore W1984091569C2780871563 @default.
• W1984091569 hasConceptScore W1984091569C2780886150 @default.
• W1984091569 hasConceptScore W1984091569C42219234 @default.
• W1984091569 hasConceptScore W1984091569C71924100 @default.
• W1984091569 hasConceptScore W1984091569C98274493 @default.
• W1984091569 hasIssue "9" @default.
• W1984091569 hasLocation W19840915691 @default.
• W1984091569 hasOpenAccess W1984091569 @default.
• W1984091569 hasPrimaryLocation W19840915691 @default.
• W1984091569 hasRelatedWork W1988290596 @default.
• W1984091569 hasRelatedWork W2067312146 @default.
• W1984091569 hasRelatedWork W2082861883 @default.
• W1984091569 hasRelatedWork W2084204626 @default.
• W1984091569 hasRelatedWork W2101643484 @default.
• W1984091569 hasRelatedWork W2135624255 @default.
• W1984091569 hasRelatedWork W2352146179 @default.
• W1984091569 hasRelatedWork W2901260704 @default.
• W1984091569 hasRelatedWork W3016912492 @default.
• W1984091569 hasRelatedWork W4236571835 @default.

• next