FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984094580> ?p ?o ?g. }

• W1984094580 endingPage "1719" @default.
• W1984094580 startingPage "1705" @default.
• W1984094580 abstract "Glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides that interact with a variety of positively charged growth factors. In this review article the effects of engineering GAG chemistry for molecular delivery applications in regenerative medicine are presented. Three major areas of focus at the structure-function-property interface are discussed: (1) macromolecular properties of GAGs; (2) effects of chemical modifications on protein binding; (3) degradation mechanisms of GAGs. GAG-protein interactions can be based on: (1) GAG sulfation pattern; (2) GAG carbohydrate conformation; (3) GAG polyelectrolyte behavior. Chemical modifications of GAGs, which are commonly performed to engineer molecular delivery systems, affect protein binding and are highly dependent on the site of modification on the GAG molecules. The rate and mode of degradation can determine the release of molecules as well as the length of GAG fragments to which the cargo is electrostatically coupled and eventually released from the delivery system. Overall, GAG-based polymers are a versatile biomaterial platform offering novel means to engineer molecular delivery systems with a high degree of control in order to better treat a range of degenerated or injured tissues." @default.
• W1984094580 created "2016-06-24" @default.
• W1984094580 creator A5024616884 @default.
• W1984094580 creator A5039088654 @default.
• W1984094580 creator A5048802181 @default.
• W1984094580 creator A5066980281 @default.
• W1984094580 date "2014-04-01" @default.
• W1984094580 modified "2023-09-23" @default.
• W1984094580 title "Molecular engineering of glycosaminoglycan chemistry for biomolecule delivery" @default.
• W1984094580 cites W118641700 @default.
• W1984094580 cites W127220886 @default.
• W1984094580 cites W1492404598 @default.
• W1984094580 cites W1494551606 @default.
• W1984094580 cites W1550465988 @default.
• W1984094580 cites W1564590530 @default.
• W1984094580 cites W1585431104 @default.
• W1984094580 cites W1594150232 @default.
• W1984094580 cites W1813300651 @default.
• W1984094580 cites W1897011699 @default.
• W1984094580 cites W1963945059 @default.
• W1984094580 cites W1964527179 @default.
• W1984094580 cites W1966725567 @default.
• W1984094580 cites W1971119332 @default.
• W1984094580 cites W1971222243 @default.
• W1984094580 cites W1971305486 @default.
• W1984094580 cites W1973003441 @default.
• W1984094580 cites W1974268523 @default.
• W1984094580 cites W1976301946 @default.
• W1984094580 cites W1977839571 @default.
• W1984094580 cites W1978974209 @default.
• W1984094580 cites W1982013660 @default.
• W1984094580 cites W1982423863 @default.
• W1984094580 cites W1983412455 @default.
• W1984094580 cites W1983572805 @default.
• W1984094580 cites W1985394758 @default.
• W1984094580 cites W1986012385 @default.
• W1984094580 cites W1986775865 @default.
• W1984094580 cites W1987893498 @default.
• W1984094580 cites W1988122470 @default.
• W1984094580 cites W1988534292 @default.
• W1984094580 cites W1989398037 @default.
• W1984094580 cites W1989676517 @default.
• W1984094580 cites W1989815841 @default.
• W1984094580 cites W1990755536 @default.
• W1984094580 cites W1991712854 @default.
• W1984094580 cites W1994041163 @default.
• W1984094580 cites W1994227004 @default.
• W1984094580 cites W1994962128 @default.
• W1984094580 cites W1996520568 @default.
• W1984094580 cites W1997580052 @default.
• W1984094580 cites W1997946222 @default.
• W1984094580 cites W1999205758 @default.
• W1984094580 cites W1999330037 @default.
• W1984094580 cites W2000453685 @default.
• W1984094580 cites W2003203464 @default.
• W1984094580 cites W2004490083 @default.
• W1984094580 cites W2005178280 @default.
• W1984094580 cites W2006327127 @default.
• W1984094580 cites W2007449636 @default.
• W1984094580 cites W2008782595 @default.
• W1984094580 cites W2011476024 @default.
• W1984094580 cites W2011900374 @default.
• W1984094580 cites W2013546498 @default.
• W1984094580 cites W2013679716 @default.
• W1984094580 cites W2014865280 @default.
• W1984094580 cites W2015167429 @default.
• W1984094580 cites W2015262545 @default.
• W1984094580 cites W2015976976 @default.
• W1984094580 cites W2017592559 @default.
• W1984094580 cites W2018516249 @default.
• W1984094580 cites W2020206304 @default.
• W1984094580 cites W2022660390 @default.
• W1984094580 cites W2023021192 @default.
• W1984094580 cites W2024829696 @default.
• W1984094580 cites W2025733563 @default.
• W1984094580 cites W2025990173 @default.
• W1984094580 cites W2028307915 @default.
• W1984094580 cites W2029806899 @default.
• W1984094580 cites W2029825685 @default.
• W1984094580 cites W2030571349 @default.
• W1984094580 cites W2030961193 @default.
• W1984094580 cites W2031223866 @default.
• W1984094580 cites W2032177706 @default.
• W1984094580 cites W2032351800 @default.
• W1984094580 cites W2032542771 @default.
• W1984094580 cites W2033702973 @default.
• W1984094580 cites W2033818437 @default.
• W1984094580 cites W2034564460 @default.
• W1984094580 cites W2035536358 @default.
• W1984094580 cites W2035659296 @default.
• W1984094580 cites W2037371382 @default.
• W1984094580 cites W2038038231 @default.
• W1984094580 cites W2041420763 @default.
• W1984094580 cites W2043411450 @default.
• W1984094580 cites W2045071715 @default.
• W1984094580 cites W2051437369 @default.
• W1984094580 cites W2053420250 @default.
• W1984094580 cites W2055331835 @default.

• next