FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984103180> ?p ?o ?g. }

• W1984103180 endingPage "436" @default.
• W1984103180 startingPage "426" @default.
• W1984103180 abstract "Tetrahydrobiopterin (BH4) is important for normal brain development as congenital BH4 deficiencies manifest movement disorders at various childhood ages. BH4 transitions from very low levels in fetal brains to higher adult levels postnatally, with the highest levels in the thalamus. Maternal supplementation with the BH4 precursor sepiapterin reduces postnatal motor deficits and perinatal deaths after 40-min fetal hypoxia-ischemia (HI) at 70% gestation, suggesting that brain BH4 is important in improving function after HI. We tested the hypothesis that the intrinsically low concentrations of BH4 made fetal neurons vulnerable to added insults. Brains were obtained from naïve fetal rabbits or after 40-min HI, at 70% (E22) and 92% gestation (E29). Neuronal cultures were prepared from basal ganglia, cortex, and thalamus, regions with different intrinsic levels of BH4. Cultures were grown with or without added BH4 for 48h. Cell survival and mitochondrial function were determined by flow cytometry. At E22, thalamic cells had the lowest survival rate in a BH4-free milieu, in both control and HI groups, whereas BH4 supplementation ex vivo increased neuronal survival only in HI cells. Neuronal survival was similar in all regions without BH4 at E29. BH4 supplementation increased cell survival and cells with intact mitochondrial membrane potential, from basal ganglia and cortex, but not thalamus. After E29 HI, however, the benefit of BH4 was limited to cortical neurons. We conclude that BH4 is important for fetal neuronal survival after HI especially in the premature thalamus. Supplementation of BH4 has a greater benefit at an earlier gestational age." @default.
• W1984103180 created "2016-06-24" @default.
• W1984103180 creator A5001723877 @default.
• W1984103180 creator A5015585351 @default.
• W1984103180 creator A5040519455 @default.
• W1984103180 creator A5040896846 @default.
• W1984103180 creator A5052525108 @default.
• W1984103180 creator A5073167107 @default.
• W1984103180 date "2014-02-01" @default.
• W1984103180 modified "2023-09-26" @default.
• W1984103180 title "Developmental susceptibility of neurons to transient tetrahydrobiopterin insufficiency and antenatal hypoxia–ischemia in fetal rabbits" @default.
• W1984103180 cites W1564564343 @default.
• W1984103180 cites W1581978537 @default.
• W1984103180 cites W1689675368 @default.
• W1984103180 cites W1900499785 @default.
• W1984103180 cites W1968689753 @default.
• W1984103180 cites W1990882222 @default.
• W1984103180 cites W1996409191 @default.
• W1984103180 cites W2014470329 @default.
• W1984103180 cites W2017914114 @default.
• W1984103180 cites W2045721183 @default.
• W1984103180 cites W2046637240 @default.
• W1984103180 cites W2056449960 @default.
• W1984103180 cites W2062558935 @default.
• W1984103180 cites W2063704449 @default.
• W1984103180 cites W2075453410 @default.
• W1984103180 cites W2076063914 @default.
• W1984103180 cites W2080112874 @default.
• W1984103180 cites W2092838550 @default.
• W1984103180 cites W2106964842 @default.
• W1984103180 cites W2113999599 @default.
• W1984103180 cites W2115263803 @default.
• W1984103180 cites W2134547814 @default.
• W1984103180 cites W2135821537 @default.
• W1984103180 cites W2138962306 @default.
• W1984103180 cites W2143398582 @default.
• W1984103180 cites W2150414947 @default.
• W1984103180 cites W2158667023 @default.
• W1984103180 doi "https://doi.org/10.1016/j.freeradbiomed.2013.11.026" @default.
• W1984103180 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3945116" @default.
• W1984103180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24316196" @default.
• W1984103180 hasPublicationYear "2014" @default.
• W1984103180 type Work @default.
• W1984103180 sameAs 1984103180 @default.
• W1984103180 citedByCount "9" @default.
• W1984103180 countsByYear W19841031802017 @default.
• W1984103180 countsByYear W19841031802018 @default.
• W1984103180 countsByYear W19841031802019 @default.
• W1984103180 countsByYear W19841031802020 @default.
• W1984103180 countsByYear W19841031802022 @default.
• W1984103180 countsByYear W19841031802023 @default.
• W1984103180 crossrefType "journal-article" @default.
• W1984103180 hasAuthorship W1984103180A5001723877 @default.
• W1984103180 hasAuthorship W1984103180A5015585351 @default.
• W1984103180 hasAuthorship W1984103180A5040519455 @default.
• W1984103180 hasAuthorship W1984103180A5040896846 @default.
• W1984103180 hasAuthorship W1984103180A5052525108 @default.
• W1984103180 hasAuthorship W1984103180A5073167107 @default.
• W1984103180 hasBestOaLocation W19841031802 @default.
• W1984103180 hasConcept C126322002 @default.
• W1984103180 hasConcept C134018914 @default.
• W1984103180 hasConcept C169760540 @default.
• W1984103180 hasConcept C172680121 @default.
• W1984103180 hasConcept C178790620 @default.
• W1984103180 hasConcept C185592680 @default.
• W1984103180 hasConcept C2776145790 @default.
• W1984103180 hasConcept C2777622882 @default.
• W1984103180 hasConcept C2778187257 @default.
• W1984103180 hasConcept C2779234561 @default.
• W1984103180 hasConcept C2779246727 @default.
• W1984103180 hasConcept C519581460 @default.
• W1984103180 hasConcept C529278444 @default.
• W1984103180 hasConcept C540031477 @default.
• W1984103180 hasConcept C541997718 @default.
• W1984103180 hasConcept C54355233 @default.
• W1984103180 hasConcept C71924100 @default.
• W1984103180 hasConcept C7836513 @default.
• W1984103180 hasConcept C86803240 @default.
• W1984103180 hasConceptScore W1984103180C126322002 @default.
• W1984103180 hasConceptScore W1984103180C134018914 @default.
• W1984103180 hasConceptScore W1984103180C169760540 @default.
• W1984103180 hasConceptScore W1984103180C172680121 @default.
• W1984103180 hasConceptScore W1984103180C178790620 @default.
• W1984103180 hasConceptScore W1984103180C185592680 @default.
• W1984103180 hasConceptScore W1984103180C2776145790 @default.
• W1984103180 hasConceptScore W1984103180C2777622882 @default.
• W1984103180 hasConceptScore W1984103180C2778187257 @default.
• W1984103180 hasConceptScore W1984103180C2779234561 @default.
• W1984103180 hasConceptScore W1984103180C2779246727 @default.
• W1984103180 hasConceptScore W1984103180C519581460 @default.
• W1984103180 hasConceptScore W1984103180C529278444 @default.
• W1984103180 hasConceptScore W1984103180C540031477 @default.
• W1984103180 hasConceptScore W1984103180C541997718 @default.
• W1984103180 hasConceptScore W1984103180C54355233 @default.
• W1984103180 hasConceptScore W1984103180C71924100 @default.
• W1984103180 hasConceptScore W1984103180C7836513 @default.
• W1984103180 hasConceptScore W1984103180C86803240 @default.
• W1984103180 hasLocation W19841031801 @default.

• next