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• W1984116274 abstract "No AccessJournal of UrologyAdult Urology1 Jan 2015Improved Outcomes with Advancements in High Intensity Focused Ultrasound Devices for the Treatment of Localized Prostate Cancer Toyoaki Uchida, Tetsuro Tomonaga, Hakushi Kim, Mayura Nakano, Sunao Shoji, Yoshihiro Nagata, and Toshiro Terachi Toyoaki UchidaToyoaki Uchida Department of Urology, Tokai University Hachioji Hospital, Hachioji, Japan More articles by this author , Tetsuro TomonagaTetsuro Tomonaga Department of Urology, Tokai University Hachioji Hospital, Hachioji, Japan More articles by this author , Hakushi KimHakushi Kim Department of Urology, Tokai University Hachioji Hospital, Hachioji, Japan More articles by this author , Mayura NakanoMayura Nakano Department of Urology, Tokai University Hachioji Hospital, Hachioji, Japan More articles by this author , Sunao ShojiSunao Shoji Department of Urology, Tokai University Hachioji Hospital, Hachioji, Japan More articles by this author , Yoshihiro NagataYoshihiro Nagata Department of Urology, Tokai University Hachioji Hospital, Hachioji, Japan More articles by this author , and Toshiro TerachiToshiro Terachi Department of Urology, Tokai University, Isehara, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.07.096AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the association between long-term clinical outcomes and morbidity with high intensity focused ultrasound. Materials and Methods: We included patients with stage T1c-T3N0M0 prostate cancer who were treated with Sonablate® (SB) devices during 1999 to 2012 and followed for more than 2 years. Risk stratification and complication rates were compared among the treatment groups (ie SB200/500 group, SB500 version 4 group and SB500 tissue change monitor group). Primary study outcomes included overall, cancer specific and biochemical disease-free survival rates determined using Kaplan-Meier analysis (Phoenix definition). Secondary outcomes included predictors of biochemical disease-free survival using Cox models. Results: A total of 918 patients were included in the study. Median followup in the SB200/500, SB500 version 4 and the SB500 tissue change monitor groups was 108, 83 and 47 months, respectively. The 10-year overall and cancer specific survival rates were 89.6% and 97.4%, respectively. The 5-year biochemical disease-free survival rate in the SB200/500, SB500 version 4 and SB500 tissue change monitor group was 48.3%, 62.3% and 82.0%, respectively (p <0.0001). The overall negative biopsy rate was 87.3%. On multivariate analysis pretreatment prostate specific antigen, Gleason score, stage, neoadjuvant androgen deprivation therapy and high intensity focused ultrasound devices were significant predictors of biochemical disease-free survival. Urethral stricture, epididymitis, urinary incontinence and rectourethral fistula were observed in 19.7%, 6.2%, 2.3% and 0.1% of cases, respectively. Conclusions: Long-term followup of patients with high intensity focused ultrasound demonstrated improved clinical outcomes due to technical, imaging and technological advancements. References 1 American Cancer Society: Cancer Facts & Figures 2014. Available at www.cancer.org/research/cancerfactsstatistics/cancerfactsfigures2014/. Accessed March 8, 2014. 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Google Scholar © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byBorges R, Tourinho-Barbosa R, Glina S, Macek P, Mombet A, Sanchez-Salas R and Cathelineau X (2020) Impact of Focal Versus Whole Gland Ablation for Prostate Cancer on Sexual Function and Urinary ContinenceJournal of Urology, VOL. 205, NO. 1, (129-136), Online publication date: 1-Jan-2021.Taneja S (2019) Re: A Multicentre Study of 5-Year Outcomes following Focal Therapy in Treating Clinically Significant Nonmetastatic Prostate CancerJournal of Urology, VOL. 201, NO. 3, (443-444), Online publication date: 1-Mar-2019.Bass R, Fleshner N, Finelli A, Barkin J, Zhang L and Klotz L (2018) Oncologic and Functional Outcomes of Partial Gland Ablation with High Intensity Focused Ultrasound for Localized Prostate CancerJournal of Urology, VOL. 201, NO. 1, (113-119), Online publication date: 1-Jan-2019.Babalola O, Lee T and Viviano C (2018) Prostate Ablation Using High Intensity Focused Ultrasound: A Literature Review of the Potential Role for Patient Preference InformationJournal of Urology, VOL. 200, NO. 3, (512-519), Online publication date: 1-Sep-2018.Taneja S (2016) Re: Medium-Term Outcomes after Whole-Gland High-Intensity Focused Ultrasound for the Treatment of Nonmetastatic Prostate Cancer from a Multicentre Registry CohortJournal of Urology, VOL. 196, NO. 1, (103-104), Online publication date: 1-Jul-2016.Taneja S (2015) Re: Salvage High-Intensity Focused Ultrasound for Patients with Recurrent Prostate Cancer after BrachytherapyJournal of Urology, VOL. 194, NO. 1, (114-114), Online publication date: 1-Jul-2015.Steers W (2014) This Month in Adult UrologyJournal of Urology, VOL. 193, NO. 1, (1-3), Online publication date: 1-Jan-2015. Volume 193Issue 1January 2015Page: 103-110 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.Keywordstreatment outcomehigh-intensity focused ultrasound ablationprostatic neoplasmsMetricsAuthor Information Toyoaki Uchida Department of Urology, Tokai University Hachioji Hospital, Hachioji, Japan More articles by this author Tetsuro Tomonaga Department of Urology, Tokai University Hachioji Hospital, Hachioji, Japan More articles by this author Hakushi Kim Department of Urology, Tokai University Hachioji Hospital, Hachioji, Japan More articles by this author Mayura Nakano Department of Urology, Tokai University Hachioji Hospital, Hachioji, Japan More articles by this author Sunao Shoji Department of Urology, Tokai University Hachioji Hospital, Hachioji, Japan More articles by this author Yoshihiro Nagata Department of Urology, Tokai University Hachioji Hospital, Hachioji, Japan More articles by this author Toshiro Terachi Department of Urology, Tokai University, Isehara, Japan More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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