FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984130379> ?p ?o ?g. }

• W1984130379 endingPage "558" @default.
• W1984130379 startingPage "555" @default.
• W1984130379 abstract "We showed that humanin (HN), an endogenous peptide against Alzheimer disease-related insults, was expressed in muscles of patients with chronic progressive external ophthalmoplegia (CPEO), a major mitochondrial disease. Because HN was recently found to block proapoptotic Bax function and exert its versatile cytoprotective effects in association with an increase in ATP levels, HN expression may thus reflect a physiological response against degenerative changes in the muscles of patients with CPEO. We found HN expression in all four patients examined, each of whom had different mitochondrial DNA mutations including two different single DNA deletions, multiple deletions, and no major mutations detected. We also found that HN expression was not linked to focal cytochrome c deficiency, strongly associated with the subtype of CPEO with single deletions. These results suggest that HN expression is more closely related to degenerative changes in all types of CPEO. Notably, HN was also expressed in non-degenerative muscle fibers of patients with CPEO or Leigh syndrome, who had the 8993T>G mutation in the mitochondrial ATPase 6 gene known to be associated with impaired ATP synthesis. Collectively, our findings suggest that HN may be specifically expressed in response to defects in energy production in muscles with mitochondrial abnormalities." @default.
• W1984130379 created "2016-06-24" @default.
• W1984130379 creator A5002301422 @default.
• W1984130379 creator A5007362659 @default.
• W1984130379 creator A5036330211 @default.
• W1984130379 creator A5054689680 @default.
• W1984130379 creator A5057969283 @default.
• W1984130379 creator A5069310256 @default.
• W1984130379 date "2006-04-26" @default.
• W1984130379 modified "2023-10-14" @default.
• W1984130379 title "Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia" @default.
• W1984130379 cites W1497358941 @default.
• W1984130379 cites W1967683528 @default.
• W1984130379 cites W1967886755 @default.
• W1984130379 cites W2015802342 @default.
• W1984130379 cites W2017671645 @default.
• W1984130379 cites W2019989190 @default.
• W1984130379 cites W2024380916 @default.
• W1984130379 cites W2029395446 @default.
• W1984130379 cites W2042257178 @default.
• W1984130379 cites W2066748505 @default.
• W1984130379 cites W2083233324 @default.
• W1984130379 cites W2087080349 @default.
• W1984130379 cites W2104592988 @default.
• W1984130379 cites W2115627523 @default.
• W1984130379 cites W2119687365 @default.
• W1984130379 doi "https://doi.org/10.1007/s10038-006-0397-2" @default.
• W1984130379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16639504" @default.
• W1984130379 hasPublicationYear "2006" @default.
• W1984130379 type Work @default.
• W1984130379 sameAs 1984130379 @default.
• W1984130379 citedByCount "32" @default.
• W1984130379 countsByYear W19841303792012 @default.
• W1984130379 countsByYear W19841303792013 @default.
• W1984130379 countsByYear W19841303792014 @default.
• W1984130379 countsByYear W19841303792016 @default.
• W1984130379 countsByYear W19841303792017 @default.
• W1984130379 countsByYear W19841303792018 @default.
• W1984130379 countsByYear W19841303792020 @default.
• W1984130379 countsByYear W19841303792021 @default.
• W1984130379 countsByYear W19841303792022 @default.
• W1984130379 countsByYear W19841303792023 @default.
• W1984130379 crossrefType "journal-article" @default.
• W1984130379 hasAuthorship W1984130379A5002301422 @default.
• W1984130379 hasAuthorship W1984130379A5007362659 @default.
• W1984130379 hasAuthorship W1984130379A5036330211 @default.
• W1984130379 hasAuthorship W1984130379A5054689680 @default.
• W1984130379 hasAuthorship W1984130379A5057969283 @default.
• W1984130379 hasAuthorship W1984130379A5069310256 @default.
• W1984130379 hasBestOaLocation W19841303791 @default.
• W1984130379 hasConcept C104317684 @default.
• W1984130379 hasConcept C126322002 @default.
• W1984130379 hasConcept C153911025 @default.
• W1984130379 hasConcept C24586158 @default.
• W1984130379 hasConcept C2775833069 @default.
• W1984130379 hasConcept C2777427615 @default.
• W1984130379 hasConcept C2779134260 @default.
• W1984130379 hasConcept C2780854726 @default.
• W1984130379 hasConcept C2781396761 @default.
• W1984130379 hasConcept C28859421 @default.
• W1984130379 hasConcept C2908618680 @default.
• W1984130379 hasConcept C501734568 @default.
• W1984130379 hasConcept C54355233 @default.
• W1984130379 hasConcept C71924100 @default.
• W1984130379 hasConcept C86803240 @default.
• W1984130379 hasConceptScore W1984130379C104317684 @default.
• W1984130379 hasConceptScore W1984130379C126322002 @default.
• W1984130379 hasConceptScore W1984130379C153911025 @default.
• W1984130379 hasConceptScore W1984130379C24586158 @default.
• W1984130379 hasConceptScore W1984130379C2775833069 @default.
• W1984130379 hasConceptScore W1984130379C2777427615 @default.
• W1984130379 hasConceptScore W1984130379C2779134260 @default.
• W1984130379 hasConceptScore W1984130379C2780854726 @default.
• W1984130379 hasConceptScore W1984130379C2781396761 @default.
• W1984130379 hasConceptScore W1984130379C28859421 @default.
• W1984130379 hasConceptScore W1984130379C2908618680 @default.
• W1984130379 hasConceptScore W1984130379C501734568 @default.
• W1984130379 hasConceptScore W1984130379C54355233 @default.
• W1984130379 hasConceptScore W1984130379C71924100 @default.
• W1984130379 hasConceptScore W1984130379C86803240 @default.
• W1984130379 hasIssue "6" @default.
• W1984130379 hasLocation W19841303791 @default.
• W1984130379 hasLocation W19841303792 @default.
• W1984130379 hasOpenAccess W1984130379 @default.
• W1984130379 hasPrimaryLocation W19841303791 @default.
• W1984130379 hasRelatedWork W2015075051 @default.
• W1984130379 hasRelatedWork W2033455826 @default.
• W1984130379 hasRelatedWork W2042214554 @default.
• W1984130379 hasRelatedWork W2057679880 @default.
• W1984130379 hasRelatedWork W2061554010 @default.
• W1984130379 hasRelatedWork W2121075506 @default.
• W1984130379 hasRelatedWork W2130185402 @default.
• W1984130379 hasRelatedWork W2364119373 @default.
• W1984130379 hasRelatedWork W2464158312 @default.
• W1984130379 hasRelatedWork W63322203 @default.
• W1984130379 hasVolume "51" @default.
• W1984130379 isParatext "false" @default.
• W1984130379 isRetracted "false" @default.

• next