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- W1984139230 abstract "Abstract A highly compartmentalized enzymatic network regulates the pro‐apoptotic and proliferative effects of sphingolipids. Over‐conversion of ceramide (Cer) correlates with insensitivity to apoptosis signaling (in response to chemotherapy) and to drug resistance of cancer cells. De novo sphingomyelin biosynthesis relies on non‐vesicular ceramide trafficking by the CERT (CERamide Transfer) protein. Therefore, blocking CERT transfer, thus leading to increased intracellular ceramide availability, represents a potential anticancer strategy. Our study is based on the implementation of an in vitro binding assay, supported by in silico molecular docking. It constitutes the first attempt to explore at the molecular level for the identification of novel CERT ligands. This approach is the first step toward in silico design and optimization of CERT inhibitor candidates, potentially relevant as innovative ceramide‐transfer‐targeting therapeutic agents." @default.
- W1984139230 created "2016-06-24" @default.
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- W1984139230 date "2014-09-26" @default.
- W1984139230 modified "2023-10-18" @default.
- W1984139230 title "Identification of Novel CERT Ligands as Potential Ceramide Trafficking Inhibitors" @default.
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- W1984139230 doi "https://doi.org/10.1002/cbic.201402366" @default.
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