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• W1984159050 abstract "Alloreactive human T lymphocyte clones were found to lose antigen-stimulated proliferative capacity and their ability to secrete interleukin 2 (IL 2) after a critical period in tissue culture. Instead, they gained the previously absent capacity to suppress lymphoproliferative (LP) responses in the presence or absence of exogenous IL 2. Such “ex-PLT” suppressive clones continued to grow perfectly well, retaining IL 2 and filler cell dependency, apparently normal karyotypes, and their OKT4+, OKT8− phenotypes. At least two suppressive mechanisms were demonstrated: (1) the “induction” of suppressive effectors in normal peripheral lymphocytes, and (2) a direct suppressive activity on lymphocyte proliferation shown by their ability to inhibit restimulation of cloned lymphocytes lacking suppressor cell precursors. The consistent “differentiation” from IL 2-secreting “helper” status to nonspecific suppressive status may represent a novel immunoregulatory phase in the long-term differentiation of normal human T cells." @default.
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• W1984159050 date "1984-06-01" @default.
• W1984159050 modified "2023-09-25" @default.
• W1984159050 title "Alloproliferative human T cell clones primed and cultured in vitro lose proliferative and gain suppressive activity with age" @default.
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• W1984159050 doi "https://doi.org/10.1016/0198-8859(84)90079-x" @default.
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