FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984170044> ?p ?o ?g. }

• W1984170044 endingPage "1259" @default.
• W1984170044 startingPage "1247" @default.
• W1984170044 abstract "We propose a model for normal tissue damage based on the assumption that adult mammalian stem cells have limited mobility and, consequently, for each organ, there is a maximum volume (the critical volume, Vc), that can be repopulated and repaired by a single surviving stem cell. This concept is applied to a simple, 1-dimensional model of the spinal cord, where the critical volume is a slice of thickness, t, assumed to be small compared to lengths of spinal cord usually irradiated clinically. The probability of myelitis is explicitly obtained as a function of the dose, dose per fraction, length of cord irradiated, slice thickness, number of stem cells per slice and parameters alpha and beta of the stem cell survival curve. The complication probability is expressed as a triple negative exponential function of dose analogous to the double negative exponential function for tumor control, resulting in a steep dose-response curve with short tails in both the high dose and low dose regions. We show that the model predictions are compatible with the experimental data for radiation myelitis in the rat. We discuss how this concept can be applied to other organs such as skin and to organs composed of structurally and functionally distinct subunits, such as the kidney." @default.
• W1984170044 created "2016-06-24" @default.
• W1984170044 creator A5045063420 @default.
• W1984170044 creator A5071298558 @default.
• W1984170044 date "1988-06-01" @default.
• W1984170044 modified "2023-10-16" @default.
• W1984170044 title "Local stem cell depletion model for radiation myelitis" @default.
• W1984170044 cites W1955500944 @default.
• W1984170044 cites W1973121484 @default.
• W1984170044 cites W1974420727 @default.
• W1984170044 cites W1976552930 @default.
• W1984170044 cites W1980009159 @default.
• W1984170044 cites W1982025143 @default.
• W1984170044 cites W2000237014 @default.
• W1984170044 cites W2001849705 @default.
• W1984170044 cites W2004618544 @default.
• W1984170044 cites W2005032500 @default.
• W1984170044 cites W2008118429 @default.
• W1984170044 cites W2008537747 @default.
• W1984170044 cites W2008719853 @default.
• W1984170044 cites W2010716171 @default.
• W1984170044 cites W2015626875 @default.
• W1984170044 cites W2016681837 @default.
• W1984170044 cites W2016871222 @default.
• W1984170044 cites W2017787105 @default.
• W1984170044 cites W2021193965 @default.
• W1984170044 cites W2029517266 @default.
• W1984170044 cites W2030819118 @default.
• W1984170044 cites W2041756267 @default.
• W1984170044 cites W2044205664 @default.
• W1984170044 cites W2046269882 @default.
• W1984170044 cites W2056801524 @default.
• W1984170044 cites W2063480100 @default.
• W1984170044 cites W2065631017 @default.
• W1984170044 cites W2073005838 @default.
• W1984170044 cites W2084849081 @default.
• W1984170044 cites W2086031063 @default.
• W1984170044 cites W2088949666 @default.
• W1984170044 cites W2092319277 @default.
• W1984170044 cites W2123697448 @default.
• W1984170044 cites W2124219457 @default.
• W1984170044 cites W2133059267 @default.
• W1984170044 cites W2136869515 @default.
• W1984170044 cites W2140135575 @default.
• W1984170044 cites W2143559763 @default.
• W1984170044 cites W2144746368 @default.
• W1984170044 cites W2152316646 @default.
• W1984170044 cites W2161252223 @default.
• W1984170044 cites W2162405090 @default.
• W1984170044 cites W2169596370 @default.
• W1984170044 cites W2208096546 @default.
• W1984170044 cites W2221331257 @default.
• W1984170044 cites W2266891664 @default.
• W1984170044 cites W2751694819 @default.
• W1984170044 cites W4236549981 @default.
• W1984170044 cites W4238480726 @default.
• W1984170044 doi "https://doi.org/10.1016/0360-3016(88)90404-x" @default.
• W1984170044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3384725" @default.
• W1984170044 hasPublicationYear "1988" @default.
• W1984170044 type Work @default.
• W1984170044 sameAs 1984170044 @default.
• W1984170044 citedByCount "94" @default.
• W1984170044 countsByYear W19841700442012 @default.
• W1984170044 countsByYear W19841700442013 @default.
• W1984170044 countsByYear W19841700442014 @default.
• W1984170044 countsByYear W19841700442016 @default.
• W1984170044 countsByYear W19841700442017 @default.
• W1984170044 countsByYear W19841700442021 @default.
• W1984170044 crossrefType "journal-article" @default.
• W1984170044 hasAuthorship W1984170044A5045063420 @default.
• W1984170044 hasAuthorship W1984170044A5071298558 @default.
• W1984170044 hasConcept C111337013 @default.
• W1984170044 hasConcept C118552586 @default.
• W1984170044 hasConcept C121332964 @default.
• W1984170044 hasConcept C185544564 @default.
• W1984170044 hasConcept C2777704947 @default.
• W1984170044 hasConcept C2780775167 @default.
• W1984170044 hasConcept C28328180 @default.
• W1984170044 hasConcept C2989005 @default.
• W1984170044 hasConcept C71924100 @default.
• W1984170044 hasConcept C86803240 @default.
• W1984170044 hasConcept C95444343 @default.
• W1984170044 hasConceptScore W1984170044C111337013 @default.
• W1984170044 hasConceptScore W1984170044C118552586 @default.
• W1984170044 hasConceptScore W1984170044C121332964 @default.
• W1984170044 hasConceptScore W1984170044C185544564 @default.
• W1984170044 hasConceptScore W1984170044C2777704947 @default.
• W1984170044 hasConceptScore W1984170044C2780775167 @default.
• W1984170044 hasConceptScore W1984170044C28328180 @default.
• W1984170044 hasConceptScore W1984170044C2989005 @default.
• W1984170044 hasConceptScore W1984170044C71924100 @default.
• W1984170044 hasConceptScore W1984170044C86803240 @default.
• W1984170044 hasConceptScore W1984170044C95444343 @default.
• W1984170044 hasIssue "6" @default.
• W1984170044 hasLocation W19841700441 @default.
• W1984170044 hasLocation W19841700442 @default.
• W1984170044 hasOpenAccess W1984170044 @default.
• W1984170044 hasPrimaryLocation W19841700441 @default.

• next