Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984170131> ?p ?o ?g. }
- W1984170131 endingPage "519" @default.
- W1984170131 startingPage "511" @default.
- W1984170131 abstract "Application of drug nanocrystals provides advantageous options for the pharmaceutical formulation development of poorly soluble drugs. The objective of this study was to investigate the dissolution behavior improving effects of differently sized nanocrystals of a poorly soluble model drug, indomethacin. Nanocrystal suspensions were prepared using a top-down wet milling technique with three stabilizers: poloxamer F68, poloxamer F127 and polysorbate 80. The dissolution of the differently sized indomethacin nanocrystals were investigated using a channel flow dissolution method and by UV imaging. Unmilled bulk indomethacin and physical mixtures were used as references. According to both the dissolution methods, the dissolution properties of indomethacin were improved by the particle size reduction. UV imaging was used for the first time as a dissolution testing method for fast dissolving nanoscale material. The technique provided new information about the concentration of the dissolved drug next to the sample surface; with the smallest nanocrystals (580 nm) the indomethacin concentration next to the particle surface exceeded five-fold the thermodynamic saturated indomethacin solution concentration. Thus the solubility improvement itself, not only the increased surface area for dissolution, may have an important role in the higher dissolution rates of nanocrystal formulations. Poloxamer F68 was the most optimal stabilizer in the preparation of the indomethacin nanocrystal suspensions and in the solubility and dissolution enhancement as well." @default.
- W1984170131 created "2016-06-24" @default.
- W1984170131 creator A5008612982 @default.
- W1984170131 creator A5021353433 @default.
- W1984170131 creator A5024426748 @default.
- W1984170131 creator A5041086762 @default.
- W1984170131 creator A5051485793 @default.
- W1984170131 creator A5051971077 @default.
- W1984170131 creator A5070555235 @default.
- W1984170131 date "2013-11-01" @default.
- W1984170131 modified "2023-09-25" @default.
- W1984170131 title "Dissolution study of nanocrystal powders of a poorly soluble drug by UV imaging and channel flow methods" @default.
- W1984170131 cites W1853947313 @default.
- W1984170131 cites W1967809548 @default.
- W1984170131 cites W1983332488 @default.
- W1984170131 cites W1984963931 @default.
- W1984170131 cites W1991178173 @default.
- W1984170131 cites W1991916654 @default.
- W1984170131 cites W1998045047 @default.
- W1984170131 cites W2016971948 @default.
- W1984170131 cites W2017640513 @default.
- W1984170131 cites W2022440335 @default.
- W1984170131 cites W2028417716 @default.
- W1984170131 cites W2028981457 @default.
- W1984170131 cites W2034205145 @default.
- W1984170131 cites W2038295804 @default.
- W1984170131 cites W2040722350 @default.
- W1984170131 cites W2055354698 @default.
- W1984170131 cites W2056211275 @default.
- W1984170131 cites W2058071452 @default.
- W1984170131 cites W2062346329 @default.
- W1984170131 cites W2064802984 @default.
- W1984170131 cites W2069354598 @default.
- W1984170131 cites W2069779346 @default.
- W1984170131 cites W2070051329 @default.
- W1984170131 cites W2070206132 @default.
- W1984170131 cites W2083642073 @default.
- W1984170131 cites W2088822633 @default.
- W1984170131 cites W2116182190 @default.
- W1984170131 cites W2126304346 @default.
- W1984170131 cites W2127667517 @default.
- W1984170131 cites W2149153586 @default.
- W1984170131 cites W2159465632 @default.
- W1984170131 cites W2167642476 @default.
- W1984170131 cites W2316652991 @default.
- W1984170131 cites W2333296712 @default.
- W1984170131 doi "https://doi.org/10.1016/j.ejps.2013.08.030" @default.
- W1984170131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23999036" @default.
- W1984170131 hasPublicationYear "2013" @default.
- W1984170131 type Work @default.
- W1984170131 sameAs 1984170131 @default.
- W1984170131 citedByCount "39" @default.
- W1984170131 countsByYear W19841701312014 @default.
- W1984170131 countsByYear W19841701312015 @default.
- W1984170131 countsByYear W19841701312016 @default.
- W1984170131 countsByYear W19841701312017 @default.
- W1984170131 countsByYear W19841701312018 @default.
- W1984170131 countsByYear W19841701312019 @default.
- W1984170131 countsByYear W19841701312020 @default.
- W1984170131 countsByYear W19841701312021 @default.
- W1984170131 countsByYear W19841701312022 @default.
- W1984170131 crossrefType "journal-article" @default.
- W1984170131 hasAuthorship W1984170131A5008612982 @default.
- W1984170131 hasAuthorship W1984170131A5021353433 @default.
- W1984170131 hasAuthorship W1984170131A5024426748 @default.
- W1984170131 hasAuthorship W1984170131A5041086762 @default.
- W1984170131 hasAuthorship W1984170131A5051485793 @default.
- W1984170131 hasAuthorship W1984170131A5051971077 @default.
- W1984170131 hasAuthorship W1984170131A5070555235 @default.
- W1984170131 hasConcept C101335993 @default.
- W1984170131 hasConcept C127413603 @default.
- W1984170131 hasConcept C14029885 @default.
- W1984170131 hasConcept C155574463 @default.
- W1984170131 hasConcept C155672457 @default.
- W1984170131 hasConcept C15920480 @default.
- W1984170131 hasConcept C159985019 @default.
- W1984170131 hasConcept C171250308 @default.
- W1984170131 hasConcept C175854130 @default.
- W1984170131 hasConcept C178790620 @default.
- W1984170131 hasConcept C185592680 @default.
- W1984170131 hasConcept C187530423 @default.
- W1984170131 hasConcept C192562407 @default.
- W1984170131 hasConcept C2781430271 @default.
- W1984170131 hasConcept C42360764 @default.
- W1984170131 hasConcept C521977710 @default.
- W1984170131 hasConcept C88380143 @default.
- W1984170131 hasConceptScore W1984170131C101335993 @default.
- W1984170131 hasConceptScore W1984170131C127413603 @default.
- W1984170131 hasConceptScore W1984170131C14029885 @default.
- W1984170131 hasConceptScore W1984170131C155574463 @default.
- W1984170131 hasConceptScore W1984170131C155672457 @default.
- W1984170131 hasConceptScore W1984170131C15920480 @default.
- W1984170131 hasConceptScore W1984170131C159985019 @default.
- W1984170131 hasConceptScore W1984170131C171250308 @default.
- W1984170131 hasConceptScore W1984170131C175854130 @default.
- W1984170131 hasConceptScore W1984170131C178790620 @default.
- W1984170131 hasConceptScore W1984170131C185592680 @default.
- W1984170131 hasConceptScore W1984170131C187530423 @default.