FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984172655> ?p ?o ?g. }

• W1984172655 endingPage "157" @default.
• W1984172655 startingPage "151" @default.
• W1984172655 abstract "The binding of gonadotropin-releasing hormone (GnRH) to its receptor in the anterior pituitary gland is the key molecular interaction regulating the reproductive process of mammals. Here, we report the isolation of a cDNA representing this receptor from rat anterior pituitary and the regulation of expression of its mRNA. The rat GnRH receptor cDNA was composed of 2909 nucleotides and encoded a protein containing 327 amino acids having a seven transmembrane topology. Northern blot analysis on RNA from rat pituitary, ovary and testis showed four different transcripts (5.0, 4.5, 2.5 and 1.3 kb) of which the 5.0 kb form was most abundant. The levels of expression of the transcripts were found to be highest in the pituitary followed by the ovary and the testis (about 40% and 5% compared to pituitary, respectively). Using the more sensitive reverse transcriptase/PCR technique, we also detected GnRH receptor mRNA in the adrenal and the hypothalamus. Measurement of pituitary GnRH receptor mRNA levels (the 5.0 kb form) during the estrous cycle showed the lowest levels at estrus (1.0-fold), a 2.2 ±0.57 (mean ± SEM) -fold increase at diestrus I, a 3.5 ± 0.41-fold increase at diestrus II, a 2.6 ± 0.34-fold increase on the proestrus, and a 1.9 ± 0.25-fold on the afternoon of proestrus. Removal of the ovaries led to a 2.7 ± 0.29-fold increase in GnRH receptor mRNA levels in the pituitary gland; treatment of ovariectomized rats with estrogen resulted in a significant decrease in GnRH receptor mRNA levels. Our studies demonstrate ovarian regulation of GnRH receptor mRNA expression in the anterior pituitary gland." @default.
• W1984172655 created "2016-06-24" @default.
• W1984172655 creator A5007712871 @default.
• W1984172655 creator A5018125872 @default.
• W1984172655 creator A5021801099 @default.
• W1984172655 creator A5026756354 @default.
• W1984172655 creator A5028636567 @default.
• W1984172655 creator A5088362239 @default.
• W1984172655 date "1994-05-01" @default.
• W1984172655 modified "2023-09-23" @default.
• W1984172655 title "Rat gonadotropin-releasing hormone ( GnRH) receptor: tissue expression and hormonal regulation of its mRNA" @default.
• W1984172655 cites W1586407696 @default.
• W1984172655 cites W1974170731 @default.
• W1984172655 cites W1975613363 @default.
• W1984172655 cites W2016065996 @default.
• W1984172655 cites W2017399638 @default.
• W1984172655 cites W2026853181 @default.
• W1984172655 cites W2036635876 @default.
• W1984172655 cites W2049457476 @default.
• W1984172655 cites W2058153141 @default.
• W1984172655 cites W2064098156 @default.
• W1984172655 cites W2066897038 @default.
• W1984172655 cites W2078871537 @default.
• W1984172655 cites W2090306619 @default.
• W1984172655 cites W2090977762 @default.
• W1984172655 cites W2092328389 @default.
• W1984172655 cites W2092486725 @default.
• W1984172655 cites W2093892843 @default.
• W1984172655 cites W2095940550 @default.
• W1984172655 cites W2127783662 @default.
• W1984172655 cites W4232528724 @default.
• W1984172655 cites W4242492232 @default.
• W1984172655 cites W4249792668 @default.
• W1984172655 doi "https://doi.org/10.1016/0303-7207(94)90229-1" @default.
• W1984172655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9397947" @default.
• W1984172655 hasPublicationYear "1994" @default.
• W1984172655 type Work @default.
• W1984172655 sameAs 1984172655 @default.
• W1984172655 citedByCount "73" @default.
• W1984172655 countsByYear W19841726552015 @default.
• W1984172655 countsByYear W19841726552016 @default.
• W1984172655 countsByYear W19841726552017 @default.
• W1984172655 countsByYear W19841726552018 @default.
• W1984172655 countsByYear W19841726552020 @default.
• W1984172655 countsByYear W19841726552022 @default.
• W1984172655 countsByYear W19841726552023 @default.
• W1984172655 crossrefType "journal-article" @default.
• W1984172655 hasAuthorship W1984172655A5007712871 @default.
• W1984172655 hasAuthorship W1984172655A5018125872 @default.
• W1984172655 hasAuthorship W1984172655A5021801099 @default.
• W1984172655 hasAuthorship W1984172655A5026756354 @default.
• W1984172655 hasAuthorship W1984172655A5028636567 @default.
• W1984172655 hasAuthorship W1984172655A5088362239 @default.
• W1984172655 hasConcept C104317684 @default.
• W1984172655 hasConcept C105580179 @default.
• W1984172655 hasConcept C121608353 @default.
• W1984172655 hasConcept C126322002 @default.
• W1984172655 hasConcept C134018914 @default.
• W1984172655 hasConcept C170493617 @default.
• W1984172655 hasConcept C177707886 @default.
• W1984172655 hasConcept C1998276 @default.
• W1984172655 hasConcept C2777003273 @default.
• W1984172655 hasConcept C2777658017 @default.
• W1984172655 hasConcept C2778324911 @default.
• W1984172655 hasConcept C2778575703 @default.
• W1984172655 hasConcept C2778782382 @default.
• W1984172655 hasConcept C2778894405 @default.
• W1984172655 hasConcept C2779029589 @default.
• W1984172655 hasConcept C530470458 @default.
• W1984172655 hasConcept C55493867 @default.
• W1984172655 hasConcept C71315377 @default.
• W1984172655 hasConcept C71924100 @default.
• W1984172655 hasConcept C84606932 @default.
• W1984172655 hasConcept C86803240 @default.
• W1984172655 hasConceptScore W1984172655C104317684 @default.
• W1984172655 hasConceptScore W1984172655C105580179 @default.
• W1984172655 hasConceptScore W1984172655C121608353 @default.
• W1984172655 hasConceptScore W1984172655C126322002 @default.
• W1984172655 hasConceptScore W1984172655C134018914 @default.
• W1984172655 hasConceptScore W1984172655C170493617 @default.
• W1984172655 hasConceptScore W1984172655C177707886 @default.
• W1984172655 hasConceptScore W1984172655C1998276 @default.
• W1984172655 hasConceptScore W1984172655C2777003273 @default.
• W1984172655 hasConceptScore W1984172655C2777658017 @default.
• W1984172655 hasConceptScore W1984172655C2778324911 @default.
• W1984172655 hasConceptScore W1984172655C2778575703 @default.
• W1984172655 hasConceptScore W1984172655C2778782382 @default.
• W1984172655 hasConceptScore W1984172655C2778894405 @default.
• W1984172655 hasConceptScore W1984172655C2779029589 @default.
• W1984172655 hasConceptScore W1984172655C530470458 @default.
• W1984172655 hasConceptScore W1984172655C55493867 @default.
• W1984172655 hasConceptScore W1984172655C71315377 @default.
• W1984172655 hasConceptScore W1984172655C71924100 @default.
• W1984172655 hasConceptScore W1984172655C84606932 @default.
• W1984172655 hasConceptScore W1984172655C86803240 @default.
• W1984172655 hasIssue "1-2" @default.
• W1984172655 hasLocation W19841726551 @default.
• W1984172655 hasLocation W19841726552 @default.

• next