FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984173680> ?p ?o ?g. }

• W1984173680 endingPage "180" @default.
• W1984173680 startingPage "174" @default.
• W1984173680 abstract "Fascin is an actin-bundling protein that induces membrane protrusions and cell motility after the formation of lamellipodia or filopodia. Fascin expression has been associated with progression or prognosis in various neoplasms; however, its role in intrahepatic cholangiocarcinoma is unknown. Tumor sections from 84 patients with intrahepatic cholangiocarcinoma and 16 patients with intrahepatic biliary dysplasia were stained with antifascin antibody. Fascin mRNA expression, measured by real-time reverse transcription-polymerase chain reaction in 20 frozen samples, was compared with the immunohistochemical results. Furthermore, the expression of cyclin D1 was compared with that of fascin. Immunohistochemically, fascin expression was absent or sporadic in normal biliary epithelium, whereas high expression (>70% of tumor cells) was found in 2 (12.5%) dysplasias and 30 (35.7%) intrahepatic cholangiocarcinomas. The difference between the fascin mRNA concentrations in the high-expression and low-expression groups was significant (P = .0082). Tumors showing high expression were poorly differentiated (P = .0019), and among poorly differentiated intrahepatic cholangiocarcinoma, larger tumors (>5 cm) were more likely than smaller lesions to have high fascin expression (P = .0205). A significant correlation was observed between fascin and cyclin D1 immunoreactivity (P = .0289). Patients whose tumors expressed fascin abundantly had a poorer outcome (P = .0085), and fascin overexpression was an independent prognostic factor (P = .0477). Fascin is expressed early in biliary carcinogenesis and might contribute to poor differentiation and to growth of intrahepatic cholangiocarcinoma. It is a significant indicator of a poor prognosis for patients with intrahepatic cholangiocarcinoma." @default.
• W1984173680 created "2016-06-24" @default.
• W1984173680 creator A5002294470 @default.
• W1984173680 creator A5004420462 @default.
• W1984173680 creator A5025082835 @default.
• W1984173680 creator A5044251320 @default.
• W1984173680 creator A5045044751 @default.
• W1984173680 creator A5057146510 @default.
• W1984173680 creator A5058931620 @default.
• W1984173680 creator A5086522106 @default.
• W1984173680 creator A5088216621 @default.
• W1984173680 creator A5088590521 @default.
• W1984173680 date "2009-02-01" @default.
• W1984173680 modified "2023-09-28" @default.
• W1984173680 title "Fascin overexpression is involved in carcinogenesis and prognosis of human intrahepatic cholangiocarcinoma: immunohistochemical and molecular analysis" @default.
• W1984173680 cites W1554815317 @default.
• W1984173680 cites W1967972793 @default.
• W1984173680 cites W1969263167 @default.
• W1984173680 cites W1996081115 @default.
• W1984173680 cites W2002612012 @default.
• W1984173680 cites W2025502042 @default.
• W1984173680 cites W2051153598 @default.
• W1984173680 cites W2054307087 @default.
• W1984173680 cites W2062826077 @default.
• W1984173680 cites W2067870752 @default.
• W1984173680 cites W2078797029 @default.
• W1984173680 cites W2090355988 @default.
• W1984173680 cites W2092464123 @default.
• W1984173680 cites W2104541549 @default.
• W1984173680 cites W2108437034 @default.
• W1984173680 cites W2113933820 @default.
• W1984173680 cites W2128631411 @default.
• W1984173680 cites W2128907550 @default.
• W1984173680 cites W2138373575 @default.
• W1984173680 cites W2139871687 @default.
• W1984173680 cites W2140835320 @default.
• W1984173680 cites W2146914339 @default.
• W1984173680 cites W2152025735 @default.
• W1984173680 cites W2164265402 @default.
• W1984173680 cites W2168185059 @default.
• W1984173680 cites W2177545267 @default.
• W1984173680 cites W4211234270 @default.
• W1984173680 doi "https://doi.org/10.1016/j.humpath.2008.06.029" @default.
• W1984173680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18835624" @default.
• W1984173680 hasPublicationYear "2009" @default.
• W1984173680 type Work @default.
• W1984173680 sameAs 1984173680 @default.
• W1984173680 citedByCount "31" @default.
• W1984173680 countsByYear W19841736802012 @default.
• W1984173680 countsByYear W19841736802013 @default.
• W1984173680 countsByYear W19841736802014 @default.
• W1984173680 countsByYear W19841736802015 @default.
• W1984173680 countsByYear W19841736802016 @default.
• W1984173680 countsByYear W19841736802017 @default.
• W1984173680 countsByYear W19841736802018 @default.
• W1984173680 countsByYear W19841736802019 @default.
• W1984173680 countsByYear W19841736802020 @default.
• W1984173680 countsByYear W19841736802021 @default.
• W1984173680 countsByYear W19841736802022 @default.
• W1984173680 countsByYear W19841736802023 @default.
• W1984173680 crossrefType "journal-article" @default.
• W1984173680 hasAuthorship W1984173680A5002294470 @default.
• W1984173680 hasAuthorship W1984173680A5004420462 @default.
• W1984173680 hasAuthorship W1984173680A5025082835 @default.
• W1984173680 hasAuthorship W1984173680A5044251320 @default.
• W1984173680 hasAuthorship W1984173680A5045044751 @default.
• W1984173680 hasAuthorship W1984173680A5057146510 @default.
• W1984173680 hasAuthorship W1984173680A5058931620 @default.
• W1984173680 hasAuthorship W1984173680A5086522106 @default.
• W1984173680 hasAuthorship W1984173680A5088216621 @default.
• W1984173680 hasAuthorship W1984173680A5088590521 @default.
• W1984173680 hasConcept C104317684 @default.
• W1984173680 hasConcept C105580179 @default.
• W1984173680 hasConcept C121608353 @default.
• W1984173680 hasConcept C125705527 @default.
• W1984173680 hasConcept C126322002 @default.
• W1984173680 hasConcept C142724271 @default.
• W1984173680 hasConcept C199835354 @default.
• W1984173680 hasConcept C204232928 @default.
• W1984173680 hasConcept C2778934503 @default.
• W1984173680 hasConcept C2909135397 @default.
• W1984173680 hasConcept C29537977 @default.
• W1984173680 hasConcept C502942594 @default.
• W1984173680 hasConcept C55493867 @default.
• W1984173680 hasConcept C555283112 @default.
• W1984173680 hasConcept C71924100 @default.
• W1984173680 hasConcept C86803240 @default.
• W1984173680 hasConcept C90301020 @default.
• W1984173680 hasConcept C95444343 @default.
• W1984173680 hasConceptScore W1984173680C104317684 @default.
• W1984173680 hasConceptScore W1984173680C105580179 @default.
• W1984173680 hasConceptScore W1984173680C121608353 @default.
• W1984173680 hasConceptScore W1984173680C125705527 @default.
• W1984173680 hasConceptScore W1984173680C126322002 @default.
• W1984173680 hasConceptScore W1984173680C142724271 @default.
• W1984173680 hasConceptScore W1984173680C199835354 @default.
• W1984173680 hasConceptScore W1984173680C204232928 @default.
• W1984173680 hasConceptScore W1984173680C2778934503 @default.

• next