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- W1984174587 abstract "Cyclic nucleotides modulate potassium (K) channel activity in many cells and are thought to act indirectly by inducing channel protein phosphorylation. Herein we report the isolation from rabbit of a gene encoding a K channel (Kcn1) that is specifically activated by cGMP and not by cAMP. Analysis of the deduced amino acid sequence (725 amino acids) indicates that, in addition to a core region that is highly homologous to Shaker K channels, Kcn1 also contains a cysteine-rich region similar to that of ligand-gated ion channels and a cyclic nucleotide-binding region. Northern blot analysis detects gene expression in kidney, aorta, and brain. Kcn1 represents a class of K channels that may be specifically regulated by cGMP and could play an important role in mediating the effects of substances, such as nitric oxide, that increase intracellular cGMP." @default.
- W1984174587 created "2016-06-24" @default.
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- W1984174587 date "1995-12-05" @default.
- W1984174587 modified "2023-09-24" @default.
- W1984174587 title "Primary structure and functional expression of a cGMP-gated potassium channel." @default.
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- W1984174587 doi "https://doi.org/10.1073/pnas.92.25.11711" @default.
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