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- W1984177079 abstract "Purpose To investigate the hypothesis that induction of therapeutic hypothermia with cannabinoid receptor agonist WIN55,212-2 and extracorporeal life support (ECLS) after cardiac arrest is an effective heart preservation strategy. Methods and Materials Ventricular fibrillation (VF) was induced in male Wistar rats. After 10 min of untreated VF, venoarterial ECLS was instituted and rats were randomized to three groups of ten: normothermia, therapeutic hypothermia (32°C) and pharmacological hypothermia by WIN55,212 intravenous infusion (1 mg/kg/h). After 120 minutes heterotopic heart transplantation was performed in syngeneic donors using a working heart model. After 24 hours left ventricular (LV) systolic and diastolic functions were evaluated at different preloads using a conductance catheter. Results WIN55,212-2 led to a significantly better recovery of the slope of the LV end-systolic pressure volume relationship (Ees) and Preload recruitable stroke work (PRSW) than hypothermia and normothermia: as percent of baseline 87+12 vs 54+9 vs 39+11 and 88+11 vs 59+10 vs 33+8 respectively (p.01). LV stiffness expressed by end-diastolic pressure volume relationship (EDPVR) was significantly lower after WIN55,212-2 administration (p Conclusions Pharmacologically induced hypohermia with WIN55,212-2 during ECLS improve myocardial protection through activation of the pro-survival kinase Akt and ERK and could be an organ preservation strategy after cardiac arrest." @default.
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- W1984177079 date "2013-04-01" @default.
- W1984177079 modified "2023-09-27" @default.
- W1984177079 title "Pharmacologically Induced Hypothermia with WIN55,212-2 and Extracorporeal Life Support after Cardiac Arrest as a Preservation Strategy for Heart Transplantation" @default.
- W1984177079 doi "https://doi.org/10.1016/j.healun.2013.01.261" @default.
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