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- W1984179915 abstract "Abstract The single-dose and steady-state pharmacokinetics of estradiol (E 2 ), estrone, and norethindrone acetate (NETA) were examined in three studies of healthy postmenopausal women after application of a transdermal patch delivering 50/140, 50/250, or 50/400 μg/d of E 2 and NETA (E 2 /NETA). In a single-dose study, the area under the serum concentration—time curve (AUC) and the maximum serum concentrations (C max ) of E 2 and norethindrone (NET) were 24% and 28% higher, respectively, when the E 2 /NETA 50/250-μg/d patch was applied to the abdomen compared with the buttocks of 18 women. Single and multiple applications of the patches containing the three E 2 /NETA formulations resulted in the delivery of constant serum concentrations of E 2 , estrone, and NET at steady state. Significant differences were observed between E 2 /NETA 50/250 μg/d and E 2 /NETA 50/140 and 50/400 μg/d with regard to average serum concentrations (C avg ) and AUC at steady-state (AUC ss ), indicating that E 2 /NETA 50/140 μg/d delivers lower serum E 2 concentrations and E 2 /NETA 50/400 μg/d delivers higher serum E 2 concentrations when compared with E 2 /NETA 50/250 μg/d. E 2 /NETA 50/250 μg/d was bioequivalent to E 2 50 μg/d as evidenced by bioequivalent AUC ss , C avg , and C max estimates. E 2 /NETA 50/140 μg/d delivered approximately 6% less E 2 , and E 2 /NETA 50/400 μg/d delivered approximately 10% more E 2 than E 2 50 μg/d. The delivery of NET from the three formulations of E 2 /NETA was dose proportional. In summary, all three E 2 /NETA formulations maintained constant serum concentrations of E 2 and NET during the dosing interval." @default.
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- W1984179915 date "1998-10-01" @default.
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- W1984179915 title "Evaluation of the bioavailability and dose proportionality of three formulations of a combination estrogen and progestin adhesive-based matrix transdermal delivery system" @default.
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- W1984179915 doi "https://doi.org/10.1016/s0011-393x(98)85026-1" @default.
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