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• W1984181944 abstract "Bacterial lipopolysaccharide (LPS, 1 microgram/ml) induced the rapid production of tumor necrosis factor (TNF-alpha) mRNA in the RAW264 macrophage-like cell line. TNF-alpha mRNA peaked within 45 min of LPS treatment and remained high for greater than 3 hr. Transcription of TNF-alpha mRNA was increased within 15 min of LPS treatment. The quantity of TNF-alpha mRNA in LPS-stimulated cells was reduced to basal levels by treatment with cAMP, cAMP analogs, or agents which raise intracellular cAMP. This was not a general effect on all mRNA levels as the expression of a second gene, ornithine decarboxylase, was enhanced by cAMP treatment. cAMP did not have an effect on the stability of TNF-alpha mRNA. This is in contrast to the protein synthesis inhibitor, cycloheximide, which leads to a stabilization of TNF-alpha mRNA. Our results suggest that the primary regulation of tumor necrosis factor by cAMP and LPS occurs at the transcriptional level." @default.
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• W1984181944 date "1989-05-01" @default.
• W1984181944 modified "2023-09-26" @default.
• W1984181944 title "Regulation of tumor necrosis factor expression in a macrophage-like cell line by lipopolysaccharide and cyclic AMP" @default.
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• W1984181944 doi "https://doi.org/10.1016/0008-8749(89)90198-6" @default.
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