Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984197190> ?p ?o ?g. }
- W1984197190 endingPage "4139" @default.
- W1984197190 startingPage "4130" @default.
- W1984197190 abstract "The recreation of an in vitro microenvironment to understand and manipulate the proliferation and migration of invasive breast cancer cells may allow one to put a halt to their metastasis capacity. Invasive cancer cells have been linked to embryonic stem (ES) cells as they possess certain similar characteristics and gene signatures. Embryonic microenvironments have the potential to reprogram cancer cells into a less invasive phenotype and help elucidate tumorigenesis and metastasis. In this study, we explored the feasibility of reconstructing embryonic microenvironments using mouse ES cells cultured in alginate hydrogel and investigated the interactions of ES cells and highly invasive breast cancer cells in 2D, 2&1/2D, and 3D cultures. Results showed that mouse ES cells inhibited the growth and tumor spheroid formation of breast cancer cells. The mouse ES cell microenvironment was further constructed and optimized in 3D alginate hydrogel microbeads, and co-cultured with breast cancer cells. Migration analysis displayed a significant reduction in the average velocity and trajectory of breast cancer cell locomotion compared to control, suggesting that bioengineered mouse ES cell microenvironments inhibited the proliferation and migration of breast cancer cells. This study may act as a platform to open up new options to understand and harness tumor cell plasticity and develop therapeutics for metastatic breast cancer." @default.
- W1984197190 created "2016-06-24" @default.
- W1984197190 creator A5014992921 @default.
- W1984197190 creator A5052342707 @default.
- W1984197190 creator A5055059104 @default.
- W1984197190 creator A5070222700 @default.
- W1984197190 date "2011-06-01" @default.
- W1984197190 modified "2023-10-16" @default.
- W1984197190 title "Bioengineering embryonic stem cell microenvironments for exploring inhibitory effects on metastatic breast cancer cells" @default.
- W1984197190 cites W1488563510 @default.
- W1984197190 cites W1569056654 @default.
- W1984197190 cites W1964596167 @default.
- W1984197190 cites W1966288407 @default.
- W1984197190 cites W1967293289 @default.
- W1984197190 cites W1968428572 @default.
- W1984197190 cites W1969252837 @default.
- W1984197190 cites W1971801942 @default.
- W1984197190 cites W1975343681 @default.
- W1984197190 cites W1977608305 @default.
- W1984197190 cites W1978861648 @default.
- W1984197190 cites W1979976356 @default.
- W1984197190 cites W1985237401 @default.
- W1984197190 cites W1990772223 @default.
- W1984197190 cites W1991073285 @default.
- W1984197190 cites W2003194781 @default.
- W1984197190 cites W2004403900 @default.
- W1984197190 cites W2004895836 @default.
- W1984197190 cites W2010251891 @default.
- W1984197190 cites W2012228805 @default.
- W1984197190 cites W2016263863 @default.
- W1984197190 cites W2026563267 @default.
- W1984197190 cites W2026632078 @default.
- W1984197190 cites W2028279702 @default.
- W1984197190 cites W2032210732 @default.
- W1984197190 cites W2032461554 @default.
- W1984197190 cites W2033364737 @default.
- W1984197190 cites W2033474014 @default.
- W1984197190 cites W2034828193 @default.
- W1984197190 cites W2035235278 @default.
- W1984197190 cites W2036453287 @default.
- W1984197190 cites W2036463195 @default.
- W1984197190 cites W2045761513 @default.
- W1984197190 cites W2045789904 @default.
- W1984197190 cites W2047266588 @default.
- W1984197190 cites W2048633285 @default.
- W1984197190 cites W2049820772 @default.
- W1984197190 cites W2050165619 @default.
- W1984197190 cites W2050910055 @default.
- W1984197190 cites W2052154679 @default.
- W1984197190 cites W2052898353 @default.
- W1984197190 cites W2054922344 @default.
- W1984197190 cites W2057131748 @default.
- W1984197190 cites W2057697306 @default.
- W1984197190 cites W2058362959 @default.
- W1984197190 cites W2059307437 @default.
- W1984197190 cites W2062265555 @default.
- W1984197190 cites W2062614509 @default.
- W1984197190 cites W2062932571 @default.
- W1984197190 cites W2066276903 @default.
- W1984197190 cites W2066828810 @default.
- W1984197190 cites W2068502571 @default.
- W1984197190 cites W2070613007 @default.
- W1984197190 cites W2070995271 @default.
- W1984197190 cites W2072023447 @default.
- W1984197190 cites W2073759231 @default.
- W1984197190 cites W2074196850 @default.
- W1984197190 cites W2076393990 @default.
- W1984197190 cites W2078576156 @default.
- W1984197190 cites W2079060712 @default.
- W1984197190 cites W2080415915 @default.
- W1984197190 cites W2088319207 @default.
- W1984197190 cites W2088378780 @default.
- W1984197190 cites W2091995773 @default.
- W1984197190 cites W2095104577 @default.
- W1984197190 cites W2095554214 @default.
- W1984197190 cites W2098928818 @default.
- W1984197190 cites W2099225188 @default.
- W1984197190 cites W2104879427 @default.
- W1984197190 cites W2105076285 @default.
- W1984197190 cites W2107307011 @default.
- W1984197190 cites W2113547540 @default.
- W1984197190 cites W2114661172 @default.
- W1984197190 cites W2119144544 @default.
- W1984197190 cites W2122608403 @default.
- W1984197190 cites W2123232388 @default.
- W1984197190 cites W2126750664 @default.
- W1984197190 cites W2127362646 @default.
- W1984197190 cites W2128423968 @default.
- W1984197190 cites W2131266938 @default.
- W1984197190 cites W2132484189 @default.
- W1984197190 cites W2134257943 @default.
- W1984197190 cites W2138286889 @default.
- W1984197190 cites W2141596026 @default.
- W1984197190 cites W2142739240 @default.
- W1984197190 cites W2143655634 @default.
- W1984197190 cites W2146092038 @default.
- W1984197190 cites W2146322233 @default.
- W1984197190 cites W2154010000 @default.