FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984200312> ?p ?o ?g. }

• W1984200312 endingPage "826" @default.
• W1984200312 startingPage "826" @default.
• W1984200312 abstract "Background and purpose Cortical hyperexcitability has been identified as an important pathogenic mechanism in motor neuron disease ( MND ). The issue as to whether cortical hyperexcitability is a common process across the MND phenotypes, including amyotrophic lateral sclerosis ( ALS ) and primary lateral sclerosis ( PLS ), remains unresolved. Separately, the clinical distinction between PLS and ‘mimic disorders’ such as hereditary spastic paraparesis ( HSP ) may be difficult, potentially delaying diagnosis. Consequently, the aim of the present study was to determine the nature and spectrum of cortical excitability changes across the MND phenotypes, and to determine whether the presence of cortical dysfunction distinguishes PLS from HSP . Methods Cortical excitability studies were undertaken on a cohort of 14 PLS , 82 ALS and 13 HSP patients with mutations in the spastin gene. Results Cortical hyperexcitability, as heralded by reduction of short interval intracortical inhibition ( PLS 0.26%, −3.8% to 1.4%; ALS −0.15%, −3.6% to 7.0%; P < 0.01) and cortical silent period duration ( CSP PLS 172.2 ± 5.4 ms; CSP ALS 178.1 ± 5.1 ms; P < 0.001), along with an increase in intracortical facilitation was evident in ALS and PLS phenotypes, although appeared more frequently in ALS. Inexcitability of the motor cortex was more frequent in PLS ( PLS 71%, ALS 24%, P < 0.0001). Cortical excitability was preserved in HSP . Conclusions Cortical dysfunction appears to be an intrinsic process across the MND phenotypes, with cortical inexcitability predominating in PLS and cortical hyperexcitability predominating in ALS . Importantly, cortical excitability was preserved in HSP , thereby suggesting that the presence of cortical dysfunction could help differentiate PLS from HSP in a clinical setting." @default.
• W1984200312 created "2016-06-24" @default.
• W1984200312 creator A5004515243 @default.
• W1984200312 creator A5013031372 @default.
• W1984200312 creator A5045037139 @default.
• W1984200312 creator A5060424866 @default.
• W1984200312 creator A5067245074 @default.
• W1984200312 creator A5075876034 @default.
• W1984200312 creator A5078141872 @default.
• W1984200312 creator A5088811737 @default.
• W1984200312 date "2015-02-12" @default.
• W1984200312 modified "2023-09-25" @default.
• W1984200312 title "Cortical excitability changes distinguish the motor neuron disease phenotypes from hereditary spastic paraplegia" @default.
• W1984200312 cites W1907551740 @default.
• W1984200312 cites W1969807302 @default.
• W1984200312 cites W1981948679 @default.
• W1984200312 cites W1990917848 @default.
• W1984200312 cites W1991192713 @default.
• W1984200312 cites W1992045345 @default.
• W1984200312 cites W1996576454 @default.
• W1984200312 cites W2002745020 @default.
• W1984200312 cites W2014898107 @default.
• W1984200312 cites W2017482047 @default.
• W1984200312 cites W2019706623 @default.
• W1984200312 cites W2023425002 @default.
• W1984200312 cites W2030893485 @default.
• W1984200312 cites W2034031504 @default.
• W1984200312 cites W2034582883 @default.
• W1984200312 cites W2038027593 @default.
• W1984200312 cites W2042889317 @default.
• W1984200312 cites W2059998598 @default.
• W1984200312 cites W2073701161 @default.
• W1984200312 cites W2094469765 @default.
• W1984200312 cites W2099956943 @default.
• W1984200312 cites W2108381339 @default.
• W1984200312 cites W2111845093 @default.
• W1984200312 cites W2117890656 @default.
• W1984200312 cites W2118792323 @default.
• W1984200312 cites W2124727655 @default.
• W1984200312 cites W2127360982 @default.
• W1984200312 cites W2133922904 @default.
• W1984200312 cites W2136681577 @default.
• W1984200312 cites W2137893253 @default.
• W1984200312 cites W2142064395 @default.
• W1984200312 cites W2143695435 @default.
• W1984200312 cites W2149371897 @default.
• W1984200312 cites W2159867596 @default.
• W1984200312 cites W2160856744 @default.
• W1984200312 cites W2169288901 @default.
• W1984200312 cites W2254387234 @default.
• W1984200312 cites W2268498449 @default.
• W1984200312 cites W2322504897 @default.
• W1984200312 cites W2397673459 @default.
• W1984200312 cites W2913609543 @default.
• W1984200312 cites W3149641400 @default.
• W1984200312 doi "https://doi.org/10.1111/ene.12669" @default.
• W1984200312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25683471" @default.
• W1984200312 hasPublicationYear "2015" @default.
• W1984200312 type Work @default.
• W1984200312 sameAs 1984200312 @default.
• W1984200312 citedByCount "42" @default.
• W1984200312 countsByYear W19842003122015 @default.
• W1984200312 countsByYear W19842003122016 @default.
• W1984200312 countsByYear W19842003122017 @default.
• W1984200312 countsByYear W19842003122018 @default.
• W1984200312 countsByYear W19842003122019 @default.
• W1984200312 countsByYear W19842003122020 @default.
• W1984200312 countsByYear W19842003122021 @default.
• W1984200312 countsByYear W19842003122022 @default.
• W1984200312 countsByYear W19842003122023 @default.
• W1984200312 crossrefType "journal-article" @default.
• W1984200312 hasAuthorship W1984200312A5004515243 @default.
• W1984200312 hasAuthorship W1984200312A5013031372 @default.
• W1984200312 hasAuthorship W1984200312A5045037139 @default.
• W1984200312 hasAuthorship W1984200312A5060424866 @default.
• W1984200312 hasAuthorship W1984200312A5067245074 @default.
• W1984200312 hasAuthorship W1984200312A5075876034 @default.
• W1984200312 hasAuthorship W1984200312A5078141872 @default.
• W1984200312 hasAuthorship W1984200312A5088811737 @default.
• W1984200312 hasConcept C104317684 @default.
• W1984200312 hasConcept C127716648 @default.
• W1984200312 hasConcept C142724271 @default.
• W1984200312 hasConcept C15744967 @default.
• W1984200312 hasConcept C169760540 @default.
• W1984200312 hasConcept C24998067 @default.
• W1984200312 hasConcept C2778373776 @default.
• W1984200312 hasConcept C2779134260 @default.
• W1984200312 hasConcept C2780395223 @default.
• W1984200312 hasConcept C2780596555 @default.
• W1984200312 hasConcept C2781354215 @default.
• W1984200312 hasConcept C55493867 @default.
• W1984200312 hasConcept C71924100 @default.
• W1984200312 hasConcept C86803240 @default.
• W1984200312 hasConceptScore W1984200312C104317684 @default.
• W1984200312 hasConceptScore W1984200312C127716648 @default.
• W1984200312 hasConceptScore W1984200312C142724271 @default.
• W1984200312 hasConceptScore W1984200312C15744967 @default.
• W1984200312 hasConceptScore W1984200312C169760540 @default.

• next