FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984203003> ?p ?o ?g. }

• W1984203003 endingPage "515" @default.
• W1984203003 startingPage "507" @default.
• W1984203003 abstract "The clinical use of the antineoplastic agent paclitaxel (Taxol) is significantly limited in its effectiveness by a dose-related painful peripheral neuropathy. To evaluate underlying mechanisms, we developed a model of Taxol-induced painful peripheral neuropathy in the rat and determined the involvement of two second messengers that contribute to enhanced nociception in other models of inflammatory and neuropathic pain, protein kinase Cepsilon and protein kinase A. Taxol administered acutely, or chronically over 12 days, produced a decrease in mechanical nociceptive threshold. Acutely, Taxol induced hyperalgesia that was significant within 1 h, maximal after 6 h and resolved completely by 24 h after a single treatment. Chronically, Taxol treatment resulted in a dose (0.1-1 mg/kg/day)-dependent decrease in nociceptive threshold, measured 24 h after administration, maximal within 5 days from the commencement of Taxol administration and resolving by 2 weeks after the last dose of Taxol. Chronic Taxol treatment also increased the number of action potentials evoked by sustained (60-s) threshold and suprathreshold (10-g) stimulation of a sub-population of C-fibers in rats with Taxol-induced hyperalgesia. Mechanical allodynia and thermal hyperalgesia were also present in Taxol-treated rats. Hyperalgesia, produced by both acute and chronic Taxol, was attenuated by intradermal injection of selective second messenger antagonists for protein kinase Cepsilon and protein kinase A. These findings provide insight into the mechanism of Taxol-induced painful peripheral neuropathy that may help control side effects of chemotherapy and improve its clinical efficacy." @default.
• W1984203003 created "2016-06-24" @default.
• W1984203003 creator A5033208393 @default.
• W1984203003 creator A5037181353 @default.
• W1984203003 creator A5044509371 @default.
• W1984203003 creator A5066418974 @default.
• W1984203003 date "2001-12-01" @default.
• W1984203003 modified "2023-10-11" @default.
• W1984203003 title "Role of protein kinase Cϵ and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat" @default.
• W1984203003 cites W1493707960 @default.
• W1984203003 cites W1526407692 @default.
• W1984203003 cites W1939115083 @default.
• W1984203003 cites W1964609862 @default.
• W1984203003 cites W1966373586 @default.
• W1984203003 cites W1968019215 @default.
• W1984203003 cites W1968423730 @default.
• W1984203003 cites W1973556415 @default.
• W1984203003 cites W1976419136 @default.
• W1984203003 cites W1978265027 @default.
• W1984203003 cites W1981081121 @default.
• W1984203003 cites W1982059504 @default.
• W1984203003 cites W1987465437 @default.
• W1984203003 cites W1987527812 @default.
• W1984203003 cites W1990512833 @default.
• W1984203003 cites W1998899274 @default.
• W1984203003 cites W2003237376 @default.
• W1984203003 cites W2004637463 @default.
• W1984203003 cites W2009634943 @default.
• W1984203003 cites W2014007136 @default.
• W1984203003 cites W2034664046 @default.
• W1984203003 cites W2038064303 @default.
• W1984203003 cites W2039365326 @default.
• W1984203003 cites W2039707521 @default.
• W1984203003 cites W2043464344 @default.
• W1984203003 cites W2049209075 @default.
• W1984203003 cites W2057710964 @default.
• W1984203003 cites W2058020736 @default.
• W1984203003 cites W2066350187 @default.
• W1984203003 cites W2077039218 @default.
• W1984203003 cites W2081406767 @default.
• W1984203003 cites W2084092457 @default.
• W1984203003 cites W2091525965 @default.
• W1984203003 cites W2092930252 @default.
• W1984203003 cites W2095342889 @default.
• W1984203003 cites W2096102243 @default.
• W1984203003 cites W2102551452 @default.
• W1984203003 cites W2105953958 @default.
• W1984203003 cites W2107336910 @default.
• W1984203003 cites W2120272649 @default.
• W1984203003 cites W2123881551 @default.
• W1984203003 cites W2134495718 @default.
• W1984203003 cites W2136277895 @default.
• W1984203003 cites W2162546286 @default.
• W1984203003 cites W2164648537 @default.
• W1984203003 cites W2172201406 @default.
• W1984203003 cites W2182146826 @default.
• W1984203003 cites W2184790694 @default.
• W1984203003 cites W2414034032 @default.
• W1984203003 cites W4230029895 @default.
• W1984203003 cites W99631282 @default.
• W1984203003 doi "https://doi.org/10.1016/s0306-4522(01)00425-0" @default.
• W1984203003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11738263" @default.
• W1984203003 hasPublicationYear "2001" @default.
• W1984203003 type Work @default.
• W1984203003 sameAs 1984203003 @default.
• W1984203003 citedByCount "155" @default.
• W1984203003 countsByYear W19842030032012 @default.
• W1984203003 countsByYear W19842030032013 @default.
• W1984203003 countsByYear W19842030032014 @default.
• W1984203003 countsByYear W19842030032015 @default.
• W1984203003 countsByYear W19842030032016 @default.
• W1984203003 countsByYear W19842030032017 @default.
• W1984203003 countsByYear W19842030032018 @default.
• W1984203003 countsByYear W19842030032019 @default.
• W1984203003 countsByYear W19842030032020 @default.
• W1984203003 countsByYear W19842030032021 @default.
• W1984203003 countsByYear W19842030032022 @default.
• W1984203003 countsByYear W19842030032023 @default.
• W1984203003 crossrefType "journal-article" @default.
• W1984203003 hasAuthorship W1984203003A5033208393 @default.
• W1984203003 hasAuthorship W1984203003A5037181353 @default.
• W1984203003 hasAuthorship W1984203003A5044509371 @default.
• W1984203003 hasAuthorship W1984203003A5066418974 @default.
• W1984203003 hasConcept C126322002 @default.
• W1984203003 hasConcept C134018914 @default.
• W1984203003 hasConcept C15490471 @default.
• W1984203003 hasConcept C170493617 @default.
• W1984203003 hasConcept C184235292 @default.
• W1984203003 hasConcept C185592680 @default.
• W1984203003 hasConcept C195794163 @default.
• W1984203003 hasConcept C24998067 @default.
• W1984203003 hasConcept C2776694085 @default.
• W1984203003 hasConcept C2777107010 @default.
• W1984203003 hasConcept C2777292972 @default.
• W1984203003 hasConcept C2777883359 @default.
• W1984203003 hasConcept C2779245659 @default.
• W1984203003 hasConcept C2779901536 @default.
• W1984203003 hasConcept C3673659 @default.

• next