FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984208075> ?p ?o ?g. }

• W1984208075 endingPage "1806" @default.
• W1984208075 startingPage "1796" @default.
• W1984208075 abstract "Abstract Although the ETV6–RUNX1 fusion is a frequent initiating event in childhood leukemia, its role in leukemogenesis is only partly understood. The main impact of the fusion itself is to generate and sustain a clone of clinically silent preleukemic B-cell progenitors (BCP). Additional oncogenic hits, occurring even several years later, are required for overt disease. The understanding of the features and interactions of ETV6–RUNX1–positive cells during this “latency” period may explain how these silent cells can persist and whether they could be prone to additional genetic changes. In this study, two in vitro murine models were used to investigate whether ETV6–RUNX1 alters the cellular adhesion and migration properties of BCP. ETV6–RUNX1–expressing cells showed a significant defect in the chemotactic response to CXCL12, caused by a block in CXCR4 signaling, as demonstrated by inhibition of CXCL12-associated calcium flux and lack of ERK phosphorylation. Moreover, the induction of ETV6–RUNX1 caused changes in the expression of cell-surface adhesion molecules. The expression of genes regulating the cytoskeleton was also affected, resulting in a block of CDC42 signaling. The abnormalities described here could alter the interaction of ETV6–RUNX1 preleukemic BCP with the microenvironment and contribute to the pathogenesis of the disease. Implications: Alterations in the expression of cytoskeletal regulatory genes and migration properties of BCP represent early events in the evolution of the disease, from the preleukemic phase to the clinical onset, and suggest new strategies for effective eradication of leukemia. Mol Cancer Res; 12(12); 1796–806. ©2014 AACR." @default.
• W1984208075 created "2016-06-24" @default.
• W1984208075 creator A5000258587 @default.
• W1984208075 creator A5006578843 @default.
• W1984208075 creator A5023595224 @default.
• W1984208075 creator A5037319827 @default.
• W1984208075 creator A5047191240 @default.
• W1984208075 creator A5047790868 @default.
• W1984208075 creator A5051520180 @default.
• W1984208075 creator A5055158617 @default.
• W1984208075 creator A5059024222 @default.
• W1984208075 creator A5066694212 @default.
• W1984208075 creator A5067317405 @default.
• W1984208075 creator A5073390386 @default.
• W1984208075 creator A5076365826 @default.
• W1984208075 creator A5083149907 @default.
• W1984208075 creator A5085140427 @default.
• W1984208075 creator A5088781790 @default.
• W1984208075 creator A5091256512 @default.
• W1984208075 date "2014-12-01" @default.
• W1984208075 modified "2023-10-18" @default.
• W1984208075 title "Cytoskeletal Regulatory Gene Expression and Migratory Properties of B-cell Progenitors Are Affected by the ETV6–RUNX1 Rearrangement" @default.
• W1984208075 cites W1942356165 @default.
• W1984208075 cites W1946439205 @default.
• W1984208075 cites W1949173307 @default.
• W1984208075 cites W1968952693 @default.
• W1984208075 cites W1972682349 @default.
• W1984208075 cites W1977513008 @default.
• W1984208075 cites W1980747579 @default.
• W1984208075 cites W1981478275 @default.
• W1984208075 cites W1986199526 @default.
• W1984208075 cites W1986416561 @default.
• W1984208075 cites W1997257161 @default.
• W1984208075 cites W2006996074 @default.
• W1984208075 cites W2007798124 @default.
• W1984208075 cites W2008018118 @default.
• W1984208075 cites W2014345967 @default.
• W1984208075 cites W2021133590 @default.
• W1984208075 cites W2021427120 @default.
• W1984208075 cites W2021650013 @default.
• W1984208075 cites W2026976182 @default.
• W1984208075 cites W2029344085 @default.
• W1984208075 cites W2031887664 @default.
• W1984208075 cites W2034099754 @default.
• W1984208075 cites W2039922639 @default.
• W1984208075 cites W2046882508 @default.
• W1984208075 cites W2047517401 @default.
• W1984208075 cites W2047659836 @default.
• W1984208075 cites W2050992307 @default.
• W1984208075 cites W2052893878 @default.
• W1984208075 cites W2067726388 @default.
• W1984208075 cites W2069372950 @default.
• W1984208075 cites W2070536351 @default.
• W1984208075 cites W2073240116 @default.
• W1984208075 cites W2074492065 @default.
• W1984208075 cites W2077588085 @default.
• W1984208075 cites W2079884892 @default.
• W1984208075 cites W2081601480 @default.
• W1984208075 cites W2085638666 @default.
• W1984208075 cites W2091438193 @default.
• W1984208075 cites W2103379368 @default.
• W1984208075 cites W2107277218 @default.
• W1984208075 cites W2115474273 @default.
• W1984208075 cites W2120723555 @default.
• W1984208075 cites W2121137790 @default.
• W1984208075 cites W2135891958 @default.
• W1984208075 cites W2141316782 @default.
• W1984208075 cites W2294291334 @default.
• W1984208075 cites W2323964476 @default.
• W1984208075 doi "https://doi.org/10.1158/1541-7786.mcr-14-0056-t" @default.
• W1984208075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25061103" @default.
• W1984208075 hasPublicationYear "2014" @default.
• W1984208075 type Work @default.
• W1984208075 sameAs 1984208075 @default.
• W1984208075 citedByCount "9" @default.
• W1984208075 countsByYear W19842080752016 @default.
• W1984208075 countsByYear W19842080752018 @default.
• W1984208075 countsByYear W19842080752020 @default.
• W1984208075 countsByYear W19842080752021 @default.
• W1984208075 countsByYear W19842080752022 @default.
• W1984208075 countsByYear W19842080752023 @default.
• W1984208075 crossrefType "journal-article" @default.
• W1984208075 hasAuthorship W1984208075A5000258587 @default.
• W1984208075 hasAuthorship W1984208075A5006578843 @default.
• W1984208075 hasAuthorship W1984208075A5023595224 @default.
• W1984208075 hasAuthorship W1984208075A5037319827 @default.
• W1984208075 hasAuthorship W1984208075A5047191240 @default.
• W1984208075 hasAuthorship W1984208075A5047790868 @default.
• W1984208075 hasAuthorship W1984208075A5051520180 @default.
• W1984208075 hasAuthorship W1984208075A5055158617 @default.
• W1984208075 hasAuthorship W1984208075A5059024222 @default.
• W1984208075 hasAuthorship W1984208075A5066694212 @default.
• W1984208075 hasAuthorship W1984208075A5067317405 @default.
• W1984208075 hasAuthorship W1984208075A5073390386 @default.
• W1984208075 hasAuthorship W1984208075A5076365826 @default.
• W1984208075 hasAuthorship W1984208075A5083149907 @default.
• W1984208075 hasAuthorship W1984208075A5085140427 @default.
• W1984208075 hasAuthorship W1984208075A5088781790 @default.

• next