Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984209384> ?p ?o ?g. }
- W1984209384 endingPage "e52535" @default.
- W1984209384 startingPage "e52535" @default.
- W1984209384 abstract "Genome-wide association studies (GWAS) have successfully identified a number of single-nucleotide polymorphisms (SNPs) associated with colorectal cancer (CRC) risk. However, these susceptibility loci known today explain only a small fraction of the genetic risk. Gene-gene interaction (GxG) is considered to be one source of the missing heritability. To address this, we performed a genome-wide search for pair-wise GxG associated with CRC risk using 8,380 cases and 10,558 controls in the discovery phase and 2,527 cases and 2,658 controls in the replication phase. We developed a simple, but powerful method for testing interaction, which we term the Average Risk Due to Interaction (ARDI). With this method, we conducted a genome-wide search to identify SNPs showing evidence for GxG with previously identified CRC susceptibility loci from 14 independent regions. We also conducted a genome-wide search for GxG using the marginal association screening and examining interaction among SNPs that pass the screening threshold (p<10(-4)). For the known locus rs10795668 (10p14), we found an interacting SNP rs367615 (5q21) with replication p = 0.01 and combined p = 4.19×10(-8). Among the top marginal SNPs after LD pruning (n = 163), we identified an interaction between rs1571218 (20p12.3) and rs10879357 (12q21.1) (nominal combined p = 2.51×10(-6); Bonferroni adjusted p = 0.03). Our study represents the first comprehensive search for GxG in CRC, and our results may provide new insight into the genetic etiology of CRC." @default.
- W1984209384 created "2016-06-24" @default.
- W1984209384 creator A5007768066 @default.
- W1984209384 creator A5010108244 @default.
- W1984209384 creator A5016377624 @default.
- W1984209384 creator A5019241699 @default.
- W1984209384 creator A5020564648 @default.
- W1984209384 creator A5023667273 @default.
- W1984209384 creator A5026707321 @default.
- W1984209384 creator A5034876399 @default.
- W1984209384 creator A5034883098 @default.
- W1984209384 creator A5035274153 @default.
- W1984209384 creator A5036777611 @default.
- W1984209384 creator A5041111453 @default.
- W1984209384 creator A5041461230 @default.
- W1984209384 creator A5042390536 @default.
- W1984209384 creator A5043367098 @default.
- W1984209384 creator A5046966186 @default.
- W1984209384 creator A5048819576 @default.
- W1984209384 creator A5049975246 @default.
- W1984209384 creator A5053074659 @default.
- W1984209384 creator A5053520269 @default.
- W1984209384 creator A5053681099 @default.
- W1984209384 creator A5059266566 @default.
- W1984209384 creator A5060105528 @default.
- W1984209384 creator A5061038538 @default.
- W1984209384 creator A5061298063 @default.
- W1984209384 creator A5062804698 @default.
- W1984209384 creator A5063065323 @default.
- W1984209384 creator A5064529676 @default.
- W1984209384 creator A5066410308 @default.
- W1984209384 creator A5068835941 @default.
- W1984209384 creator A5070703103 @default.
- W1984209384 creator A5072103440 @default.
- W1984209384 creator A5073098968 @default.
- W1984209384 creator A5073774490 @default.
- W1984209384 creator A5077206620 @default.
- W1984209384 creator A5081787961 @default.
- W1984209384 creator A5082578863 @default.
- W1984209384 creator A5083671777 @default.
- W1984209384 creator A5084496654 @default.
- W1984209384 creator A5086740139 @default.
- W1984209384 creator A5088911424 @default.
- W1984209384 creator A5090508414 @default.
- W1984209384 creator A5091653870 @default.
- W1984209384 date "2012-12-26" @default.
- W1984209384 modified "2023-10-17" @default.
- W1984209384 title "Genome-Wide Search for Gene-Gene Interactions in Colorectal Cancer" @default.
- W1984209384 cites W1539593569 @default.
- W1984209384 cites W1623769990 @default.
- W1984209384 cites W1636022999 @default.
- W1984209384 cites W1966315117 @default.
- W1984209384 cites W1966360257 @default.
- W1984209384 cites W1966844606 @default.
- W1984209384 cites W1968006026 @default.
- W1984209384 cites W1974701509 @default.
- W1984209384 cites W1975993620 @default.
- W1984209384 cites W1976114760 @default.
- W1984209384 cites W1989204866 @default.
- W1984209384 cites W1991460649 @default.
- W1984209384 cites W1997915675 @default.
- W1984209384 cites W2007846880 @default.
- W1984209384 cites W2019559291 @default.
- W1984209384 cites W2023026302 @default.
- W1984209384 cites W2025306791 @default.
- W1984209384 cites W2027350554 @default.
- W1984209384 cites W2033735406 @default.
- W1984209384 cites W2036307272 @default.
- W1984209384 cites W2041514837 @default.
- W1984209384 cites W2048352123 @default.
- W1984209384 cites W2054552261 @default.
- W1984209384 cites W2056949311 @default.
- W1984209384 cites W2057621960 @default.
- W1984209384 cites W2059542829 @default.
- W1984209384 cites W2063575312 @default.
- W1984209384 cites W2072573113 @default.
- W1984209384 cites W2082058760 @default.
- W1984209384 cites W2084142217 @default.
- W1984209384 cites W2086099578 @default.
- W1984209384 cites W2089728737 @default.
- W1984209384 cites W2091298691 @default.
- W1984209384 cites W2092691551 @default.
- W1984209384 cites W2102267300 @default.
- W1984209384 cites W2102413929 @default.
- W1984209384 cites W2103722643 @default.
- W1984209384 cites W2104504285 @default.
- W1984209384 cites W2105842551 @default.
- W1984209384 cites W2106675244 @default.
- W1984209384 cites W2108194350 @default.
- W1984209384 cites W2108201848 @default.
- W1984209384 cites W2110808585 @default.
- W1984209384 cites W2122039687 @default.
- W1984209384 cites W2123178249 @default.
- W1984209384 cites W2129133658 @default.
- W1984209384 cites W2132039887 @default.
- W1984209384 cites W2140040043 @default.
- W1984209384 cites W2140126911 @default.
- W1984209384 cites W2142438434 @default.