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• W1984216687 abstract "Caffeine is one of the most widely used - and may be abused - xenobiotic compounds in the world. If numerous pharmacological properties of caffeine have been reported, the effects of caffeine treatment on the hepatic drug-metabolizing enzyme system have been scarcely studied. Pretreatment of rats for 3 days with 150 mg/kg/day of caffeine dramatically increased P4501A and P4502B dependent catalytic activities determined in vitro. Furthermore, N-demethylations and C-8 oxidation of caffeine were increased by about 2 fold by caffeine treatment. Immunoblot analysis demonstrated that the liver contents of P4501A2 and P4502B1/2B2, known to be involved in these monooxygenase activities, increased also by about 2 fold. Cytochrome P4503A1 and 2E1 were not modified. Taken together, there data suggest that caffeine increases its own metabolism through P4501A induction." @default.
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• W1984216687 date "1995-06-01" @default.
• W1984216687 modified "2023-09-25" @default.
• W1984216687 title "Caffeine increases its own metabolism through cytochrome P4501A induction in rats" @default.
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• W1984216687 doi "https://doi.org/10.1016/0024-3205(95)00304-o" @default.
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