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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984224729> ?p ?o ?g. }

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• W1984224729 abstract "The discovery of novel and highly potent oxopiperazine based B1 receptor antagonists is described. Compared to the previously described arylsulfonylated (R)-3-amino-3-phenylpropionic acid series, the current compounds showed improved in vitro potency and metabolic stability. Compound 17, 2-((2R)-1-((4-methylphenyl)sulfonyl)-3-oxo-2-piperazinyl)-N-((1R)-6-(1-piperidinylmethyl)-1,2,3,4-tetrahydro-1-naphthalenyl)acetamide, showed EC50 of 10.3 nM in a rabbit biochemical challenge model. The practical syntheses of chiral arylsulfonylated oxopiperazine acetic acids are also described." @default.
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• W1984224729 date "2011-06-01" @default.
• W1984224729 modified "2023-09-26" @default.
• W1984224729 title "3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation" @default.
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• W1984224729 doi "https://doi.org/10.1016/j.bmcl.2011.03.115" @default.
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