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• W1984225101 endingPage "107" @default.
• W1984225101 startingPage "97" @default.
• W1984225101 abstract "The ultimate goal of any genome-scale experiment is to provide a functional interpretation of the results, relating the available genomic information to the hypotheses that originated the experiment.Initially, this interpretation has been made on a pre-selection of relevant genes, based on the experimental values, followed by the study of the enrichment in some functional properties. Nevertheless, functional enrichment methods, demonstrated to have a flaw: the first step of gene selection was too stringent given that the cooperation among genes was ignored. The assumption that modules of genes related by relevant biological properties (functionality, co-regulation, chromosomal location, etc.) are the real actors of the cell biology lead to the development of new procedures, inspired in systems biology criteria, generically known as gene-set methods. These methods have been successfully used to analyze transcriptomic and large-scale genotyping experiments as well as to test other different genome-scale hypothesis in other fields such as phylogenomics." @default.
• W1984225101 created "2016-06-24" @default.
• W1984225101 creator A5067601660 @default.
• W1984225101 date "2009-02-01" @default.
• W1984225101 modified "2023-09-23" @default.
• W1984225101 title "Formulating and testing hypotheses in functional genomics" @default.
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