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- W1984227946 abstract "The distribution of [14C]dimethylnitrosamine was studied by wholebody autoradiography in mice. By applying low temperature autoradiography and autoradiography with dried tape sections in mice with inhibited (by pretreatment with pyrazole, ethanol, or nialamide) and noninhibited dimethylnitrosamine metabolism, a distinction was possible between the distribution of the volatile nonmetabolized dimethylnitrosamine and the nonvolatile metabolites. The results indicated a uniform distribution of the nonmetabolized dimethylnitrosamine in the body. At the short survival intervals, metabolites were trapped primarily in the liver and also to a low degree in the kidneys, probably reflecting the alkylating reactions and other reactions connected with the breakdown of dimethylnitrosamine. At the long survival intervals, metabolites also occurred in tissues with a rapid cell turnover and a high rate of protein synthesis. Since autoradiography of [14C]formaldehyde gave this distribution picture, incorporation of radioactivity from [14C]dimethylnitrosamine via [14C]formaldehyde in the one-carbon pool probably explains the labeling of these tissues. Pyrazole, ethanol, and nialamide strongly depressed the incorporation of radioactivity from [14C]dimethylnitrosamine into the acid-insoluble material of the liver. In addition, the pretreatments caused a strong inhibition of the exhalation of 14CO2 from [14C]dimethylnitrosamine." @default.
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- W1984227946 date "1978-08-01" @default.
- W1984227946 modified "2023-10-12" @default.
- W1984227946 title "The distribution of [14C]dimethylnitrosamine in mice. Autoradiographic studies in mice with inhibited and noninhibited dimethylnitrosamine metabolism and a comparison with the distribution of [14C]formaldehyde" @default.
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- W1984227946 doi "https://doi.org/10.1016/0041-008x(78)90118-7" @default.
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