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• W1984242783 endingPage "502" @default.
• W1984242783 startingPage "492" @default.
• W1984242783 abstract "Interferon (IFN)-lambda1 [interleukin (IL)-29] is a member of the interferon lambda family (also known as type III interferons), whose members are distantly related to both the type I interferons and members of the IL-10 family. While IFN-lambda1 has significant antiviral activity, it is also becoming apparent that it has important immunoregulatory properties, especially with regard to the T helper type 2 (Th2) response. Previously, we have shown that IFN-lambda1 is capable of down-regulating IL-13 production in an IFN-gamma-independent manner and that this is mediated in part via monocyte-derived dendritic cells. Here, we have extended our knowledge of IFN-lambda1 regulation of the human in vitro Th2 response by examining the regulation of three major Th2 cytokines, IL-4, IL-5 and IL-13, by IFN-lambda1. Our results reveal that IFN-lambda1 preferentially inhibits IL-13 production, compared with IL-4 or IL-5. Levels of IL-13 mRNA, the amount of secreted IL-13 protein and numbers of IL-13-positive CD3(+) CD4(+) cells were all significantly diminished by IFN-lambda1. IFN-lambda1 significantly decreased some aspects of IL-4 and IL-5 production, but its effects were not as consistent as those seen on IL-13. IFN-lambda1 was also effective at decreasing IL-13 secretion under conditions designed to support the generation of Th2 cells. Irrespective of whether Concanavalin-A or T-cell-stimulatory microbeads were used, IFN-lambda1 markedly diminished IL-13 secretion in cultures where IL-4 had been added. Thus, IFN-lambda1 appears to be an inhibitor of human Th2 responses whose action is primarily directed towards IL-13 but which may also affect Th2 responses generally and does not invoke a complementary elevation of IFN-gamma secretion." @default.
• W1984242783 created "2016-06-24" @default.
• W1984242783 creator A5002382690 @default.
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• W1984242783 creator A5073165181 @default.
• W1984242783 date "2008-12-01" @default.
• W1984242783 modified "2023-10-06" @default.
• W1984242783 title "Interferon-λ1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses<i>in vitro</i>" @default.
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• W1984242783 cites W1578727637 @default.
• W1984242783 cites W1585815816 @default.
• W1984242783 cites W1601542379 @default.
• W1984242783 cites W1669690603 @default.
• W1984242783 cites W1788079032 @default.
• W1984242783 cites W182986896 @default.
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• W1984242783 cites W1975588465 @default.
• W1984242783 cites W1987009823 @default.
• W1984242783 cites W1987389251 @default.
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• W1984242783 cites W2003614722 @default.
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• W1984242783 doi "https://doi.org/10.1111/j.1365-2567.2008.02862.x" @default.
• W1984242783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2612545" @default.
• W1984242783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18547367" @default.
• W1984242783 hasPublicationYear "2008" @default.
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