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• W1984248139 abstract "Sal‐like protein 2 (Sall2), a homeotic transcription factor, is a putative tumor suppressor. We have previously shown that Sall2 activates the transcription of tumor suppressor gene p21 and suppresses tumorigenesis through cell cycle inhibition and induction of apoptosis. To investigate additional Sall2‐regulated downstream genes, we analyzed the differences in m RNA expression profiles with and without exogenously expressed Sall2. We identified 1616 Sall2‐responsive genes through gene expression arrays. Promoter‐reporter assays of p16 INK 4A and several other tumor‐related genes indicated that the Sall2 regulation of these promoters was not significantly different between the two major forms of Sall2 with alternative exon 1 or exon 1A. Additional analysis showed that Sall2‐induced p16 promoter activation was Sall2 dose‐dependent. Deletion and site‐directed mutagenesis of the p16 promoter identified a consensus Sall2 binding site ( GGGTGGG ) proximal to the p16 transcription start site and was critical for p16 promoter activation. Finally, to confirm the significance of Sall2‐activated p16 expression in cell cycle regulation, we co‐transfected the SKOV 3 cells with a Sall2 expression construct and a p16 minigene and also co‐transfected the ES ‐2 cells with a Sall2 expression construct and the si RNA against p16 for flow cytometry analysis. Our results showed that Sall2 enhanced the p16 minigene blocking of cell cycle progression and p16 knockdown with si RNA abolished most of the Sall2 inhibition of cell cycle progression. These findings indicate that Sall2 targets multiple cell cycle regulators, including p16, through their promoters, adding knowledge to the understanding of Sall2 and p16 gene regulation, and how Sall2 deregulation may promote cancer formation." @default.
• W1984248139 created "2016-06-24" @default.
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• W1984248139 date "2015-03-01" @default.
• W1984248139 modified "2023-10-04" @default.
• W1984248139 title "Sal‐like protein 2 upregulates p16 expression through a proximal promoter element" @default.
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• W1984248139 doi "https://doi.org/10.1111/cas.12606" @default.
• W1984248139 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4376433" @default.
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