FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984249888> ?p ?o ?g. }

• W1984249888 endingPage "495" @default.
• W1984249888 startingPage "485" @default.
• W1984249888 abstract "Among bacteria, Escherichia coli are unique because they contain an amount of glutathione (GSH) comparable to that of mammalian cells. Thus, this bacterium has been suggested as a model for oxidant stress in mammalian systems. Two common strains of E. coli, ATCC 29682, a B strain, and AB 1157, a K-12 strain, were exposed to paraquat (PQ) or t-butyl hydroperoxide (TBH) and the effect on GSH, growth, and lethality was assessed. Exposure of both strains to 5 mM PQ resulted in an 80% decrease in GSH. Exposure to 5 mM TBH resulted in a 31% decrease in GSH in the K-12 strain and an 80% decrease in the B strain. No correlation was found between the GSH decrease in either strain and the PQ or TBH growth inhibitory effects. TBH exposures increased oxidized GSH (GSSG) export. However, no increase in intracellular GSSG or protein-mixed disulfides was found after exposure to either oxidant nor was GSSG secreted following PQ. After failing to inhibit GSH synthesis with buthionine sulfoximine, a B strain GSH-deficient mutant [RCI-1] was constructed. There was no difference in the growth and lethality responses to the oxidants between GSH-deficient and -sufficient strains. GSH supplementation with N-acetylcysteine or L-2-oxothiazolidine decreased the sensitivity of the E. coli B strain to the growth inhibitory but not the lethality effects of TBH. The lack of a correlation of changes in GSH with either oxidant-induced growth inhibitory or lethality effects, the presence of catalase in the cytoplasm not peroxisomes, and the absence of glutathione peroxidase are limitations to the value of this bacterium as a model for mammalian oxidant stress." @default.
• W1984249888 created "2016-06-24" @default.
• W1984249888 creator A5016529846 @default.
• W1984249888 date "1991-12-01" @default.
• W1984249888 modified "2023-09-26" @default.
• W1984249888 title "The evaluation of Escherichia coli as a model for oxidant stress in mammalian hepatocytes: Role of glutathione" @default.
• W1984249888 cites W1493036774 @default.
• W1984249888 cites W1498636565 @default.
• W1984249888 cites W1535828429 @default.
• W1984249888 cites W1539388657 @default.
• W1984249888 cites W1546783991 @default.
• W1984249888 cites W1560558424 @default.
• W1984249888 cites W1561329310 @default.
• W1984249888 cites W1591193929 @default.
• W1984249888 cites W1664689314 @default.
• W1984249888 cites W1680863695 @default.
• W1984249888 cites W1940436875 @default.
• W1984249888 cites W1949711541 @default.
• W1984249888 cites W1966915474 @default.
• W1984249888 cites W1968005725 @default.
• W1984249888 cites W1975586826 @default.
• W1984249888 cites W1981108341 @default.
• W1984249888 cites W1986778713 @default.
• W1984249888 cites W1992477389 @default.
• W1984249888 cites W1999170854 @default.
• W1984249888 cites W2012876546 @default.
• W1984249888 cites W2023178182 @default.
• W1984249888 cites W2028673240 @default.
• W1984249888 cites W2047710688 @default.
• W1984249888 cites W2054075222 @default.
• W1984249888 cites W2069425802 @default.
• W1984249888 cites W2071596742 @default.
• W1984249888 cites W2076055378 @default.
• W1984249888 cites W2077181520 @default.
• W1984249888 cites W2077479423 @default.
• W1984249888 cites W2082614090 @default.
• W1984249888 cites W2083808373 @default.
• W1984249888 cites W2084703008 @default.
• W1984249888 cites W2126370064 @default.
• W1984249888 cites W2129172494 @default.
• W1984249888 cites W2170800444 @default.
• W1984249888 cites W2243150402 @default.
• W1984249888 cites W2282054059 @default.
• W1984249888 cites W2282219104 @default.
• W1984249888 cites W2398668204 @default.
• W1984249888 cites W2409413906 @default.
• W1984249888 cites W2463765700 @default.
• W1984249888 cites W34845076 @default.
• W1984249888 cites W758260955 @default.
• W1984249888 cites W2013731390 @default.
• W1984249888 doi "https://doi.org/10.1016/0041-008x(91)90252-a" @default.
• W1984249888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1660631" @default.
• W1984249888 hasPublicationYear "1991" @default.
• W1984249888 type Work @default.
• W1984249888 sameAs 1984249888 @default.
• W1984249888 citedByCount "15" @default.
• W1984249888 countsByYear W19842498882013 @default.
• W1984249888 countsByYear W19842498882020 @default.
• W1984249888 crossrefType "journal-article" @default.
• W1984249888 hasAuthorship W1984249888A5016529846 @default.
• W1984249888 hasConcept C104317684 @default.
• W1984249888 hasConcept C105702510 @default.
• W1984249888 hasConcept C153911025 @default.
• W1984249888 hasConcept C181199279 @default.
• W1984249888 hasConcept C185592680 @default.
• W1984249888 hasConcept C2776151105 @default.
• W1984249888 hasConcept C2777476445 @default.
• W1984249888 hasConcept C2778022156 @default.
• W1984249888 hasConcept C2778979269 @default.
• W1984249888 hasConcept C538909803 @default.
• W1984249888 hasConcept C547475151 @default.
• W1984249888 hasConcept C55493867 @default.
• W1984249888 hasConcept C79879829 @default.
• W1984249888 hasConcept C86803240 @default.
• W1984249888 hasConcept C89423630 @default.
• W1984249888 hasConceptScore W1984249888C104317684 @default.
• W1984249888 hasConceptScore W1984249888C105702510 @default.
• W1984249888 hasConceptScore W1984249888C153911025 @default.
• W1984249888 hasConceptScore W1984249888C181199279 @default.
• W1984249888 hasConceptScore W1984249888C185592680 @default.
• W1984249888 hasConceptScore W1984249888C2776151105 @default.
• W1984249888 hasConceptScore W1984249888C2777476445 @default.
• W1984249888 hasConceptScore W1984249888C2778022156 @default.
• W1984249888 hasConceptScore W1984249888C2778979269 @default.
• W1984249888 hasConceptScore W1984249888C538909803 @default.
• W1984249888 hasConceptScore W1984249888C547475151 @default.
• W1984249888 hasConceptScore W1984249888C55493867 @default.
• W1984249888 hasConceptScore W1984249888C79879829 @default.
• W1984249888 hasConceptScore W1984249888C86803240 @default.
• W1984249888 hasConceptScore W1984249888C89423630 @default.
• W1984249888 hasIssue "3" @default.
• W1984249888 hasLocation W19842498881 @default.
• W1984249888 hasLocation W19842498882 @default.
• W1984249888 hasOpenAccess W1984249888 @default.
• W1984249888 hasPrimaryLocation W19842498881 @default.
• W1984249888 hasRelatedWork W1549498308 @default.
• W1984249888 hasRelatedWork W1593739904 @default.
• W1984249888 hasRelatedWork W2000917288 @default.

• next