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• W1984251825 endingPage "347" @default.
• W1984251825 startingPage "340" @default.
• W1984251825 abstract "The intracellular concentration of many steroids and xenobiotics is influenced by the membrane protein P-glycoprotein (Pgp). It has been inferred that the intracellular retention of many drugs that upregulate Pgp or modulate Pgp function might also be affected by Pgp. However, the ability of Pgp to influence the translocation of these drugs needs to be established to understand Pgp's influence upon their pharmacological effect. We utilized two approaches to determine the interaction of several agents with Pgp: (a) anin vitrosystem, LLC-PK1 cell lines and derivative LLC cell lines stably expressing on the apical membrane either mousemdr1aor humanMDR1Pgp grown as polarized epithelium in transwell culture to measure translocation of radiolabeled drugs; and (b) anin vivosystem,mdr1anullizygous and wild-type animals, to compare the contribution of Pgp toin vivodistribution of radiolabeled drugs. In combination these complementary approaches identified erythromycin as a drug whose intracellular retention is influenced by Pgp, while the intracellular accumulation and tissue distribution of retinoic acid and benzo(a)pyrene were unaffected by Pgp." @default.
• W1984251825 created "2016-06-24" @default.
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• W1984251825 date "1998-02-01" @default.
• W1984251825 modified "2023-10-11" @default.
• W1984251825 title "HumanMDR1and Mousemdr1aP-Glycoprotein Alter the Cellular Retention and Disposition of Erythromycin, but Not of Retinoic Acid or Benzo(a)pyrene" @default.
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• W1984251825 doi "https://doi.org/10.1006/abbi.1997.0537" @default.
• W1984251825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9473310" @default.
• W1984251825 hasPublicationYear "1998" @default.
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