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• W1984254677 abstract "Apoptosis was inhibited in rat cardiomyocytes pretreated with the aspartic protease inhibitor pepstatin A and subsequently exposed to naphthazarin (5,8-dihydroxy-1,4-naphthoquinone). Cathepsin D was released from lysosomes to the cytosol upon exposure to naphthazarin, and the enzyme activity decreased simultaneously. Later, cathepsin D reappeared in granules of increased size, and enzyme activity was restored. Activation of caspase-3-like proteases was detected, and the number of cells showing apoptotic morphology increased with time. Pepstatin A pretreatment did not prevent release of cathepsin D from lysosomes but did significantly inhibit subsequent naphthazarin-induced caspase activation and apoptotic morphology. This suggests that cathepsin D exerts its apoptosis-stimulating effect upstream of caspase-3-like activation." @default.
• W1984254677 created "2016-06-24" @default.
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• W1984254677 date "2000-01-01" @default.
• W1984254677 modified "2023-10-16" @default.
• W1984254677 title "Inhibition of Cathepsin D Prevents Free-Radical-Induced Apoptosis in Rat Cardiomyocytes" @default.
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• W1984254677 doi "https://doi.org/10.1006/abbi.1999.1567" @default.
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