Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984258049> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1984258049 endingPage "356" @default.
- W1984258049 startingPage "352" @default.
- W1984258049 abstract "Resistance to antimonial drugs is rarely observed in immunocompetent patients.A 1-year-old girl was admitted suffering from persistent fever. A diagnosis of visceral leishmaniasis was made. The patient was given two courses of meglumine antimoniate (Glucantime) (60 mg/kg/d for 15 days) and one course of 12 injections of pentamidine (4 mg/kg). She relapsed 8 months later and failed to respond to Glucantime. Immunological tests performed during the relapse showed a suppression of the T cell response to Leishmania antigen and no production of interferon gamma. The patient was then successfully given liposomal amphotericin B (3 mg/kg/d for 10 days). She was asymptomatic 9 months later and had acquired specific cellular immunity against Leishmania.Deficient cell-mediated immunity and interferon gamma production are some factors responsible for decreased sensitivity to antimonial drugs. The WHO recommendations treating visceral leishmaniasis with prolonged administration of Glucantime may prevent relapses. Liposomal amphotericin B could be an alternative treatment." @default.
- W1984258049 created "2016-06-24" @default.
- W1984258049 creator A5008914363 @default.
- W1984258049 creator A5018652787 @default.
- W1984258049 creator A5040799438 @default.
- W1984258049 creator A5051440924 @default.
- W1984258049 creator A5055636631 @default.
- W1984258049 creator A5081419783 @default.
- W1984258049 date "1996-04-01" @default.
- W1984258049 modified "2023-09-27" @default.
- W1984258049 title "Résistance de Leishmania infantum au Glucantime®: circonstances de survenue et prise en charge thérapeutique" @default.
- W1984258049 cites W1772540997 @default.
- W1984258049 cites W1864147783 @default.
- W1984258049 cites W1964666902 @default.
- W1984258049 cites W1965533093 @default.
- W1984258049 cites W1974485086 @default.
- W1984258049 cites W1982817061 @default.
- W1984258049 cites W1983584866 @default.
- W1984258049 cites W2028773547 @default.
- W1984258049 cites W2041613782 @default.
- W1984258049 cites W2053132846 @default.
- W1984258049 cites W2058327396 @default.
- W1984258049 cites W2068659785 @default.
- W1984258049 cites W2072939818 @default.
- W1984258049 cites W2079143206 @default.
- W1984258049 cites W2123479775 @default.
- W1984258049 cites W2151324264 @default.
- W1984258049 cites W2153743322 @default.
- W1984258049 cites W2317008929 @default.
- W1984258049 cites W64981325 @default.
- W1984258049 doi "https://doi.org/10.1016/0929-693x(96)84691-4" @default.
- W1984258049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8762958" @default.
- W1984258049 hasPublicationYear "1996" @default.
- W1984258049 type Work @default.
- W1984258049 sameAs 1984258049 @default.
- W1984258049 citedByCount "8" @default.
- W1984258049 countsByYear W19842580492021 @default.
- W1984258049 crossrefType "journal-article" @default.
- W1984258049 hasAuthorship W1984258049A5008914363 @default.
- W1984258049 hasAuthorship W1984258049A5018652787 @default.
- W1984258049 hasAuthorship W1984258049A5040799438 @default.
- W1984258049 hasAuthorship W1984258049A5051440924 @default.
- W1984258049 hasAuthorship W1984258049A5055636631 @default.
- W1984258049 hasAuthorship W1984258049A5081419783 @default.
- W1984258049 hasConcept C126322002 @default.
- W1984258049 hasConcept C136764020 @default.
- W1984258049 hasConcept C16005928 @default.
- W1984258049 hasConcept C203014093 @default.
- W1984258049 hasConcept C2776555147 @default.
- W1984258049 hasConcept C2777530519 @default.
- W1984258049 hasConcept C2777914695 @default.
- W1984258049 hasConcept C2778689377 @default.
- W1984258049 hasConcept C2779548794 @default.
- W1984258049 hasConcept C2779629538 @default.
- W1984258049 hasConcept C2780423678 @default.
- W1984258049 hasConcept C2781092759 @default.
- W1984258049 hasConcept C2781257258 @default.
- W1984258049 hasConcept C41008148 @default.
- W1984258049 hasConcept C71924100 @default.
- W1984258049 hasConcept C71928629 @default.
- W1984258049 hasConcept C90924648 @default.
- W1984258049 hasConceptScore W1984258049C126322002 @default.
- W1984258049 hasConceptScore W1984258049C136764020 @default.
- W1984258049 hasConceptScore W1984258049C16005928 @default.
- W1984258049 hasConceptScore W1984258049C203014093 @default.
- W1984258049 hasConceptScore W1984258049C2776555147 @default.
- W1984258049 hasConceptScore W1984258049C2777530519 @default.
- W1984258049 hasConceptScore W1984258049C2777914695 @default.
- W1984258049 hasConceptScore W1984258049C2778689377 @default.
- W1984258049 hasConceptScore W1984258049C2779548794 @default.
- W1984258049 hasConceptScore W1984258049C2779629538 @default.
- W1984258049 hasConceptScore W1984258049C2780423678 @default.
- W1984258049 hasConceptScore W1984258049C2781092759 @default.
- W1984258049 hasConceptScore W1984258049C2781257258 @default.
- W1984258049 hasConceptScore W1984258049C41008148 @default.
- W1984258049 hasConceptScore W1984258049C71924100 @default.
- W1984258049 hasConceptScore W1984258049C71928629 @default.
- W1984258049 hasConceptScore W1984258049C90924648 @default.
- W1984258049 hasIssue "4" @default.
- W1984258049 hasLocation W19842580491 @default.
- W1984258049 hasLocation W19842580492 @default.
- W1984258049 hasOpenAccess W1984258049 @default.
- W1984258049 hasPrimaryLocation W19842580491 @default.
- W1984258049 hasRelatedWork W103991714 @default.
- W1984258049 hasRelatedWork W1964336640 @default.
- W1984258049 hasRelatedWork W2084420388 @default.
- W1984258049 hasRelatedWork W2095943555 @default.
- W1984258049 hasRelatedWork W2161310866 @default.
- W1984258049 hasRelatedWork W2414972781 @default.
- W1984258049 hasRelatedWork W2563659309 @default.
- W1984258049 hasRelatedWork W2990376326 @default.
- W1984258049 hasRelatedWork W3143738516 @default.
- W1984258049 hasRelatedWork W3164052038 @default.
- W1984258049 hasVolume "3" @default.
- W1984258049 isParatext "false" @default.
- W1984258049 isRetracted "false" @default.
- W1984258049 magId "1984258049" @default.
- W1984258049 workType "article" @default.