Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984261943> ?p ?o ?g. }
- W1984261943 endingPage "4888" @default.
- W1984261943 startingPage "4877" @default.
- W1984261943 abstract "The remarkable structural polymorphism of quadruplex-forming sequences has been a considerable impediment in the elucidation of quadruplex folds. Sequence modifications have commonly been used to perturb and purportedly select a particular form out of the ensemble of folds for nuclear magnetic resonance (NMR) or X-ray crystallographic analysis. Here we report a simple chromatographic technique that separates the individual folds without need for sequence modification. The sequence d(GGTGGTGGTGGTTGTGGTGGTGGTGG) forms a compact quadruplex according to a variety of common biophysical techniques. However, NMR and chromatography showed that this oligonucleotide produces at least eight monomeric quadruplex species that interconvert very slowly at room temperature. We have used a combination of spectroscopic, hydrodynamic and thermodynamic techniques to evaluate the physicochemical properties of the mixture and the individual species. These species have almost identical thermodynamic, hydrodynamic and electrophoretic properties, but significantly different NMR and circular dichroism (CD) spectra, as well as kinetic stability. These results demonstrate that simple standard low-resolution techniques cannot always be used for quadruplex fold determination or quality control purposes, and that simple thermodynamic analysis does not directly provide interpretable thermodynamic parameters." @default.
- W1984261943 created "2016-06-24" @default.
- W1984261943 creator A5029157205 @default.
- W1984261943 creator A5063771330 @default.
- W1984261943 creator A5071197441 @default.
- W1984261943 creator A5082297148 @default.
- W1984261943 creator A5086985222 @default.
- W1984261943 date "2010-03-25" @default.
- W1984261943 modified "2023-10-17" @default.
- W1984261943 title "Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence" @default.
- W1984261943 cites W1533349658 @default.
- W1984261943 cites W1586041803 @default.
- W1984261943 cites W1965331353 @default.
- W1984261943 cites W1971128922 @default.
- W1984261943 cites W1974678019 @default.
- W1984261943 cites W1975317507 @default.
- W1984261943 cites W1978685619 @default.
- W1984261943 cites W1979903366 @default.
- W1984261943 cites W1982423104 @default.
- W1984261943 cites W1984288546 @default.
- W1984261943 cites W1990635146 @default.
- W1984261943 cites W2007812774 @default.
- W1984261943 cites W2008819364 @default.
- W1984261943 cites W2014614648 @default.
- W1984261943 cites W2036162563 @default.
- W1984261943 cites W2038929178 @default.
- W1984261943 cites W2039241171 @default.
- W1984261943 cites W2042994965 @default.
- W1984261943 cites W2044279725 @default.
- W1984261943 cites W2045284889 @default.
- W1984261943 cites W2055493491 @default.
- W1984261943 cites W2055556773 @default.
- W1984261943 cites W2060356703 @default.
- W1984261943 cites W2062724831 @default.
- W1984261943 cites W2072353911 @default.
- W1984261943 cites W2078501519 @default.
- W1984261943 cites W2081490399 @default.
- W1984261943 cites W2081781483 @default.
- W1984261943 cites W2082968128 @default.
- W1984261943 cites W2087257033 @default.
- W1984261943 cites W2100831731 @default.
- W1984261943 cites W2104454005 @default.
- W1984261943 cites W2110930298 @default.
- W1984261943 cites W2119449687 @default.
- W1984261943 cites W2120846991 @default.
- W1984261943 cites W2121069954 @default.
- W1984261943 cites W2124258497 @default.
- W1984261943 cites W2129522390 @default.
- W1984261943 cites W2131817342 @default.
- W1984261943 cites W2138465485 @default.
- W1984261943 cites W2157384800 @default.
- W1984261943 cites W2165153689 @default.
- W1984261943 cites W2166630132 @default.
- W1984261943 cites W2166976426 @default.
- W1984261943 cites W2168158291 @default.
- W1984261943 cites W2169745877 @default.
- W1984261943 cites W2172060739 @default.
- W1984261943 cites W2343350205 @default.
- W1984261943 cites W4244090531 @default.
- W1984261943 doi "https://doi.org/10.1093/nar/gkq166" @default.
- W1984261943 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2919704" @default.
- W1984261943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20348136" @default.
- W1984261943 hasPublicationYear "2010" @default.
- W1984261943 type Work @default.
- W1984261943 sameAs 1984261943 @default.
- W1984261943 citedByCount "134" @default.
- W1984261943 countsByYear W19842619432012 @default.
- W1984261943 countsByYear W19842619432013 @default.
- W1984261943 countsByYear W19842619432014 @default.
- W1984261943 countsByYear W19842619432015 @default.
- W1984261943 countsByYear W19842619432016 @default.
- W1984261943 countsByYear W19842619432017 @default.
- W1984261943 countsByYear W19842619432018 @default.
- W1984261943 countsByYear W19842619432019 @default.
- W1984261943 countsByYear W19842619432020 @default.
- W1984261943 countsByYear W19842619432021 @default.
- W1984261943 countsByYear W19842619432022 @default.
- W1984261943 countsByYear W19842619432023 @default.
- W1984261943 crossrefType "journal-article" @default.
- W1984261943 hasAuthorship W1984261943A5029157205 @default.
- W1984261943 hasAuthorship W1984261943A5063771330 @default.
- W1984261943 hasAuthorship W1984261943A5071197441 @default.
- W1984261943 hasAuthorship W1984261943A5082297148 @default.
- W1984261943 hasAuthorship W1984261943A5086985222 @default.
- W1984261943 hasBestOaLocation W19842619431 @default.
- W1984261943 hasConcept C129312508 @default.
- W1984261943 hasConcept C133571119 @default.
- W1984261943 hasConcept C185592680 @default.
- W1984261943 hasConcept C2778112365 @default.
- W1984261943 hasConcept C552990157 @default.
- W1984261943 hasConcept C55493867 @default.
- W1984261943 hasConcept C66974803 @default.
- W1984261943 hasConcept C71240020 @default.
- W1984261943 hasConcept C83762044 @default.
- W1984261943 hasConcept C86803240 @default.
- W1984261943 hasConceptScore W1984261943C129312508 @default.
- W1984261943 hasConceptScore W1984261943C133571119 @default.
- W1984261943 hasConceptScore W1984261943C185592680 @default.