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• W1984270295 endingPage "e24784" @default.
• W1984270295 startingPage "e24784" @default.
• W1984270295 abstract "This study examined the ability of P.falciparum-infected erythrocytes (IE) to induce a pro-adhesive environment in the host endothelium during malaria infection, prior to the systemic cytokine activation seen in the later phase of disease. Previous work had shown increases in receptor levels but had not measured to actual impact on IE binding. Using a co-culture system with a range of endothelial cells (EC) and IE with different cytoadherent properties, we have characterised the specific expression of adhesion receptors and subsequent IE binding by FACS and adhesion assays. We have also examined the specific signalling pathways induced during co-culture that are potentially involved in the induction of receptor expression. The results confirmed that ICAM-1 is up-regulated, albeit at much lower levels than seen with TNF activation, in response to co-culture with infected erythrocytes in all three tissue endothelial cell types tested but that up-regulation of VCAM-1 is tissue-dependent. This small increase in the levels of EC receptors correlated with large changes in IE adhesion ability. Co-culture with either RBC or IE increased the potential of subsequent adhesion indicating priming/modulation effects on EC which make them more susceptible to adhesion and thereby the recruitment of IE. Trypsin surface digestion of IE and the use of a Pfsbp1-knockout (ko) parasite line abrogated the up-regulation of ICAM-1 and reduced IE binding to EC suggesting that PfEMP-1 and other molecules exported to the IE surface via the PfSBP1 pathway are major mediators of this phenotype. This was also supported by the higher induction of EC adhesion receptors by adherent IE compared to isogenic, non-adherent lines." @default.
• W1984270295 created "2016-06-24" @default.
• W1984270295 creator A5023260739 @default.
• W1984270295 creator A5049228932 @default.
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• W1984270295 creator A5080757734 @default.
• W1984270295 date "2011-10-17" @default.
• W1984270295 modified "2023-10-03" @default.
• W1984270295 title "Amplification of P. falciparum Cytoadherence through Induction of a Pro-Adhesive State in Host Endothelium" @default.
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• W1984270295 doi "https://doi.org/10.1371/journal.pone.0024784" @default.
• W1984270295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3197193" @default.
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• W1984270295 hasPublicationYear "2011" @default.
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