Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984272022> ?p ?o ?g. }
- W1984272022 endingPage "403" @default.
- W1984272022 startingPage "393" @default.
- W1984272022 abstract "Background and Objectives Accurate assessment of medication impact requires modeling cumulative effects of exposure duration and dose; however, postmarketing studies usually represent medication exposure by baseline or current use only. We propose new methods for modeling various aspects of medication use history and employment of them to assess the adverse effects of selected benzodiazepines. Study Design and Setting Time-dependent measures of cumulative dose or duration of use, with weighting of past exposures by recency, were proposed. These measures were then included in alternative versions of the multivariable Cox model to analyze the risk of fall related injuries among the elderly new users of three benzodiazepines (nitrazepam, temazepam, and flurazepam) in Quebec. Akaike's information criterion (AIC) was used to select the most predictive model for a given benzodiazepine. Results The best-fitting model included a combination of cumulative duration and current dose for temazepam, and cumulative dose for flurazepam and nitrazepam, with different weighting functions. The window of clinically relevant exposure was shorter for flurazepam than for the two other products. Conclusion Careful modeling of the medication exposure history may enhance our understanding of the mechanisms underlying their adverse effects." @default.
- W1984272022 created "2016-06-24" @default.
- W1984272022 creator A5005722794 @default.
- W1984272022 creator A5029938799 @default.
- W1984272022 creator A5045091586 @default.
- W1984272022 creator A5069438785 @default.
- W1984272022 date "2006-04-01" @default.
- W1984272022 modified "2023-10-15" @default.
- W1984272022 title "Modeling cumulative dose and exposure duration provided insights regarding the associations between benzodiazepines and injuries" @default.
- W1984272022 cites W1506269003 @default.
- W1984272022 cites W1599942278 @default.
- W1984272022 cites W1964073424 @default.
- W1984272022 cites W1966714873 @default.
- W1984272022 cites W1967818970 @default.
- W1984272022 cites W1971947433 @default.
- W1984272022 cites W1990501193 @default.
- W1984272022 cites W1992136793 @default.
- W1984272022 cites W1992623433 @default.
- W1984272022 cites W1996715439 @default.
- W1984272022 cites W1999033589 @default.
- W1984272022 cites W1999576264 @default.
- W1984272022 cites W2002831021 @default.
- W1984272022 cites W2024612449 @default.
- W1984272022 cites W2025434594 @default.
- W1984272022 cites W2031479780 @default.
- W1984272022 cites W2031518017 @default.
- W1984272022 cites W2041665349 @default.
- W1984272022 cites W2045420468 @default.
- W1984272022 cites W2049728968 @default.
- W1984272022 cites W2050363168 @default.
- W1984272022 cites W2054167035 @default.
- W1984272022 cites W2066701790 @default.
- W1984272022 cites W2068806248 @default.
- W1984272022 cites W2077991158 @default.
- W1984272022 cites W2084252616 @default.
- W1984272022 cites W2084607683 @default.
- W1984272022 cites W2085615121 @default.
- W1984272022 cites W2086143553 @default.
- W1984272022 cites W2086820273 @default.
- W1984272022 cites W2111054196 @default.
- W1984272022 cites W2113276704 @default.
- W1984272022 cites W2119700347 @default.
- W1984272022 cites W2123450918 @default.
- W1984272022 cites W2141929817 @default.
- W1984272022 cites W2142635246 @default.
- W1984272022 cites W2154020881 @default.
- W1984272022 cites W2156843744 @default.
- W1984272022 cites W2160893557 @default.
- W1984272022 cites W2164676198 @default.
- W1984272022 cites W2167834874 @default.
- W1984272022 cites W2221794218 @default.
- W1984272022 cites W2318925269 @default.
- W1984272022 cites W2330709704 @default.
- W1984272022 cites W4231370352 @default.
- W1984272022 cites W4232350687 @default.
- W1984272022 cites W4239158944 @default.
- W1984272022 cites W4241794855 @default.
- W1984272022 cites W4243115484 @default.
- W1984272022 cites W4248478309 @default.
- W1984272022 cites W4248722048 @default.
- W1984272022 doi "https://doi.org/10.1016/j.jclinepi.2005.01.021" @default.
- W1984272022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16549262" @default.
- W1984272022 hasPublicationYear "2006" @default.
- W1984272022 type Work @default.
- W1984272022 sameAs 1984272022 @default.
- W1984272022 citedByCount "68" @default.
- W1984272022 countsByYear W19842720222012 @default.
- W1984272022 countsByYear W19842720222013 @default.
- W1984272022 countsByYear W19842720222014 @default.
- W1984272022 countsByYear W19842720222015 @default.
- W1984272022 countsByYear W19842720222016 @default.
- W1984272022 countsByYear W19842720222017 @default.
- W1984272022 countsByYear W19842720222018 @default.
- W1984272022 countsByYear W19842720222019 @default.
- W1984272022 countsByYear W19842720222020 @default.
- W1984272022 countsByYear W19842720222021 @default.
- W1984272022 countsByYear W19842720222022 @default.
- W1984272022 countsByYear W19842720222023 @default.
- W1984272022 crossrefType "journal-article" @default.
- W1984272022 hasAuthorship W1984272022A5005722794 @default.
- W1984272022 hasAuthorship W1984272022A5029938799 @default.
- W1984272022 hasAuthorship W1984272022A5045091586 @default.
- W1984272022 hasAuthorship W1984272022A5069438785 @default.
- W1984272022 hasConcept C105795698 @default.
- W1984272022 hasConcept C112758219 @default.
- W1984272022 hasConcept C124952713 @default.
- W1984272022 hasConcept C126322002 @default.
- W1984272022 hasConcept C126674687 @default.
- W1984272022 hasConcept C126838900 @default.
- W1984272022 hasConcept C142362112 @default.
- W1984272022 hasConcept C151032500 @default.
- W1984272022 hasConcept C170493617 @default.
- W1984272022 hasConcept C183115368 @default.
- W1984272022 hasConcept C197934379 @default.
- W1984272022 hasConcept C2776156762 @default.
- W1984272022 hasConcept C2776175493 @default.
- W1984272022 hasConcept C2777207853 @default.
- W1984272022 hasConcept C2778173252 @default.