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- W1984278328 abstract "Surgical resection has limited success in curing non-small celllung cancer (NSCLC), particularly among patients with locally advanceddisease (stage IIIA). Combined modality regimens, utilizing surgery, radiotherapy, and chemotherapy, have improved response rates, althoughthey have not been shown to significantly impact survival amongpatients with completely resected stage I and II NSCLC. Futureimprovements in NSCLC therapy, currently under investigation, arelikely to come from newer agents shown to be active in this disease andfrom alternative schedules, such as neoadjuvant or concurrent combinedmodality treatments. Neoadjuvant cisplatin-based chemotherapy hasalready been shown to increase cure rates in stage IIIA NSCLC, from 10to 15% to 25 to 30%. Newer active agents, such as paclitaxel, vinorelbine, and gemcitabine, may be able to advance the curerate even further. Radiotherapy, which has been shown to decrease therate of local recurrence, may play a role as well. Surgical resection has limited success in curing non-small celllung cancer (NSCLC), particularly among patients with locally advanceddisease (stage IIIA). Combined modality regimens, utilizing surgery, radiotherapy, and chemotherapy, have improved response rates, althoughthey have not been shown to significantly impact survival amongpatients with completely resected stage I and II NSCLC. Futureimprovements in NSCLC therapy, currently under investigation, arelikely to come from newer agents shown to be active in this disease andfrom alternative schedules, such as neoadjuvant or concurrent combinedmodality treatments. Neoadjuvant cisplatin-based chemotherapy hasalready been shown to increase cure rates in stage IIIA NSCLC, from 10to 15% to 25 to 30%. Newer active agents, such as paclitaxel, vinorelbine, and gemcitabine, may be able to advance the curerate even further. Radiotherapy, which has been shown to decrease therate of local recurrence, may play a role as well." @default.
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- W1984278328 date "2000-04-01" @default.
- W1984278328 modified "2023-10-17" @default.
- W1984278328 title "Adjuvant and Neoadjuvant Chemotherapy for Non-Small Cell Lung Cancer" @default.
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- W1984278328 doi "https://doi.org/10.1378/chest.117.4_suppl_1.119s" @default.
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