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• W1984287896 abstract "Background Turcot syndrome (TS) or the glioma-polyposis syndrome, is a rare, heritable disorder thought by some authors to be a variant of familial adenomatous polyposis (FAP). It is characterized by central nervous system (CNS) neoplasms and gastrointestinal polyposis. Methods We present a case report of a patient who developed a medulloblastoma at age 5 years. Ten years later, she developed adenocarcinoma of the colon. Seven months after resection of this Dukes’ C2 adenocarcinoma, she presented with a second primary CNS tumor, a glioblastoma multiforme. The patient’s colonic adenocarcinoma and glioblastoma were evaluated histologically and cytogenetically. Results Cytogenetic analysis revealed the presence of chromosomal instability in both tumors. This unusual case of two primary CNS neoplasms in a patient with TS is presented with a review of the literature. Conclusions The implications of the cytogenetic analysis are discussed in conjunction with the present knowledge of the molecular biology of TS." @default.
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• W1984287896 date "1998-03-01" @default.
• W1984287896 modified "2023-09-30" @default.
• W1984287896 title "Medulloblastoma and Glioblastoma Multiforme in a Patient with Turcot Syndrome: A Case Report" @default.
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• W1984287896 doi "https://doi.org/10.1016/s0090-3019(97)00214-0" @default.
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