FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984295596> ?p ?o ?g. }

• W1984295596 endingPage "1003" @default.
• W1984295596 startingPage "991" @default.
• W1984295596 abstract "We have shown that fibrin-based small-diameter tissue-engineered blood vessels (TEVs) exhibited considerable mechanical strength and could withstand implantation in the jugular veins of lambs, where they remained patent for 15 weeks. The microtopology of fibrin matrix is influenced by the concentration of fibrinogen and calcium, whereas fibrinolysis and matrix remodeling are affected by the presence of the fibrinolytic inhibitor aprotinin. Here we report the effects of these components on two key properties of TEVs, namely mechanical strength and vasoreactivity. We found that high concentrations of fibrinogen or calcium decreased significantly both strength and reactivity. Surprisingly, aprotinin increased mechanical strength but decreased vascular reactivity in a dose-dependent manner. Transforming growth factor β1 (TGF-β1) and insulin had a moderate effect on mechanical strength but significantly enhanced reactivity, through receptor- and non-receptor- mediated pathways. In addition, the combination of TGF-β1, insulin, and aprotinin resulted in significant improvement of both properties. Our data suggest that the microtopology of fibrin matrix and the rates of fibrinolysis and extracellular matrix synthesis may affect the properties of TEVs significantly. They also indicate that biomaterial and culture parameters may have differential effects on mechanical properties versus vascular reactivity and, therefore, engineering blood vessels under conditions that maximize tissue strength may not always result in optimal function. Instead, strength and reactivity must be used in concert for more accurate evaluation of tissue-engineered vascular constructs." @default.
• W1984295596 created "2016-06-24" @default.
• W1984295596 creator A5025720984 @default.
• W1984295596 creator A5030784573 @default.
• W1984295596 creator A5030788742 @default.
• W1984295596 creator A5040615889 @default.
• W1984295596 creator A5075134985 @default.
• W1984295596 date "2005-07-01" @default.
• W1984295596 modified "2023-09-26" @default.
• W1984295596 title "Fibrin-Based Tissue-Engineered Blood Vessels: Differential Effects of Biomaterial and Culture Parameters on Mechanical Strength and Vascular Reactivity" @default.
• W1984295596 cites W1496738071 @default.
• W1984295596 cites W1590987349 @default.
• W1984295596 cites W1595905214 @default.
• W1984295596 cites W1963711373 @default.
• W1984295596 cites W1964963229 @default.
• W1984295596 cites W1966672631 @default.
• W1984295596 cites W1967345630 @default.
• W1984295596 cites W1970877757 @default.
• W1984295596 cites W1974194916 @default.
• W1984295596 cites W1979516244 @default.
• W1984295596 cites W1991016293 @default.
• W1984295596 cites W2004181539 @default.
• W1984295596 cites W2009593888 @default.
• W1984295596 cites W2009900197 @default.
• W1984295596 cites W2025971094 @default.
• W1984295596 cites W2027796832 @default.
• W1984295596 cites W2059746822 @default.
• W1984295596 cites W2077178584 @default.
• W1984295596 cites W2079369870 @default.
• W1984295596 cites W2081374353 @default.
• W1984295596 cites W2081473590 @default.
• W1984295596 cites W2085056083 @default.
• W1984295596 cites W2087833741 @default.
• W1984295596 cites W2093212321 @default.
• W1984295596 cites W2093308151 @default.
• W1984295596 cites W2095838516 @default.
• W1984295596 cites W2112893205 @default.
• W1984295596 cites W2128955603 @default.
• W1984295596 cites W2157023856 @default.
• W1984295596 cites W2174695057 @default.
• W1984295596 cites W2180478 @default.
• W1984295596 cites W2224210245 @default.
• W1984295596 cites W2231915252 @default.
• W1984295596 cites W2313946183 @default.
• W1984295596 cites W2319425280 @default.
• W1984295596 doi "https://doi.org/10.1089/ten.2005.11.991" @default.
• W1984295596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1685268" @default.
• W1984295596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/848494" @default.
• W1984295596 hasPublicationYear "2005" @default.
• W1984295596 type Work @default.
• W1984295596 sameAs 1984295596 @default.
• W1984295596 citedByCount "77" @default.
• W1984295596 countsByYear W19842955962012 @default.
• W1984295596 countsByYear W19842955962013 @default.
• W1984295596 countsByYear W19842955962014 @default.
• W1984295596 countsByYear W19842955962015 @default.
• W1984295596 countsByYear W19842955962016 @default.
• W1984295596 countsByYear W19842955962017 @default.
• W1984295596 countsByYear W19842955962018 @default.
• W1984295596 countsByYear W19842955962019 @default.
• W1984295596 countsByYear W19842955962020 @default.
• W1984295596 countsByYear W19842955962021 @default.
• W1984295596 crossrefType "journal-article" @default.
• W1984295596 hasAuthorship W1984295596A5025720984 @default.
• W1984295596 hasAuthorship W1984295596A5030784573 @default.
• W1984295596 hasAuthorship W1984295596A5030788742 @default.
• W1984295596 hasAuthorship W1984295596A5040615889 @default.
• W1984295596 hasAuthorship W1984295596A5075134985 @default.
• W1984295596 hasBestOaLocation W19842955962 @default.
• W1984295596 hasConcept C12554922 @default.
• W1984295596 hasConcept C126322002 @default.
• W1984295596 hasConcept C136229726 @default.
• W1984295596 hasConcept C185592680 @default.
• W1984295596 hasConcept C189165786 @default.
• W1984295596 hasConcept C203014093 @default.
• W1984295596 hasConcept C2776825266 @default.
• W1984295596 hasConcept C2777292125 @default.
• W1984295596 hasConcept C2777663904 @default.
• W1984295596 hasConcept C2778414984 @default.
• W1984295596 hasConcept C2779036427 @default.
• W1984295596 hasConcept C2780799893 @default.
• W1984295596 hasConcept C49892992 @default.
• W1984295596 hasConcept C54173615 @default.
• W1984295596 hasConcept C55493867 @default.
• W1984295596 hasConcept C71924100 @default.
• W1984295596 hasConcept C86803240 @default.
• W1984295596 hasConcept C89560881 @default.
• W1984295596 hasConceptScore W1984295596C12554922 @default.
• W1984295596 hasConceptScore W1984295596C126322002 @default.
• W1984295596 hasConceptScore W1984295596C136229726 @default.
• W1984295596 hasConceptScore W1984295596C185592680 @default.
• W1984295596 hasConceptScore W1984295596C189165786 @default.
• W1984295596 hasConceptScore W1984295596C203014093 @default.
• W1984295596 hasConceptScore W1984295596C2776825266 @default.
• W1984295596 hasConceptScore W1984295596C2777292125 @default.
• W1984295596 hasConceptScore W1984295596C2777663904 @default.
• W1984295596 hasConceptScore W1984295596C2778414984 @default.
• W1984295596 hasConceptScore W1984295596C2779036427 @default.

• next