Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984311902> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1984311902 abstract "Although organic nitrates have been clinically used for more than a century, findings in the last decade have radically challenged our traditional view concerning the mechanism(s) of their clinical effects. This presentation will make four separate points.1. There is no doubt that when given acutely, they relieve cardiac ischemia and can reduce pulmonary congestion. Unfortunately when given chronically, without nitrate – free intervals, these beneficial effects are lost.2. There is now strong evidence that chronic therapy is associated with increased bioavailability of reactive oxygen species and that this phenomenon may result in both tolerance and adverse effects on endothelial function.3. There continues to be no evidence that these widely used drugs improve long-term outcome in patients with angina or congestive heart failure (except when given in combination with hydralazine in patients with congestive heart failure).4. Paradoxically there is now clear evidence that short-term administration of nitroglycerin and other organic nitrates are potent pharmacologic preconditioning agents and that short-term exposure (generally 2 hours) protects from the impact of ischemia reperfusion injury up to 48 hours later. We will also discuss the mechanism of this preconditioning effect.While their hemodynamic properties are well known, the knowledge that nitrates possess previously unexpected nonhemodynamic effects is a unique opportunity of which clinicians should be aware. Our group believes that tolerance, increased free radical bioavailability and their ability to precondition are likely all interrelated. A PDF of a recent editorial from our group is attached." @default.
- W1984311902 created "2016-06-24" @default.
- W1984311902 creator A5001156301 @default.
- W1984311902 creator A5088608614 @default.
- W1984311902 date "2009-08-01" @default.
- W1984311902 modified "2023-09-28" @default.
- W1984311902 title "Nitrate-induced tolerance, toxicity and preconditioning: a rationale for reconsidering the use of these drugs" @default.
- W1984311902 doi "https://doi.org/10.1186/1471-2210-9-s1-s30" @default.
- W1984311902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3313422" @default.
- W1984311902 hasPublicationYear "2009" @default.
- W1984311902 type Work @default.
- W1984311902 sameAs 1984311902 @default.
- W1984311902 citedByCount "0" @default.
- W1984311902 crossrefType "journal-article" @default.
- W1984311902 hasAuthorship W1984311902A5001156301 @default.
- W1984311902 hasAuthorship W1984311902A5088608614 @default.
- W1984311902 hasBestOaLocation W19843119021 @default.
- W1984311902 hasConcept C126322002 @default.
- W1984311902 hasConcept C164705383 @default.
- W1984311902 hasConcept C177713679 @default.
- W1984311902 hasConcept C181389837 @default.
- W1984311902 hasConcept C197934379 @default.
- W1984311902 hasConcept C2778198053 @default.
- W1984311902 hasConcept C2778425758 @default.
- W1984311902 hasConcept C2780521442 @default.
- W1984311902 hasConcept C500558357 @default.
- W1984311902 hasConcept C541997718 @default.
- W1984311902 hasConcept C71924100 @default.
- W1984311902 hasConcept C84393581 @default.
- W1984311902 hasConcept C98274493 @default.
- W1984311902 hasConceptScore W1984311902C126322002 @default.
- W1984311902 hasConceptScore W1984311902C164705383 @default.
- W1984311902 hasConceptScore W1984311902C177713679 @default.
- W1984311902 hasConceptScore W1984311902C181389837 @default.
- W1984311902 hasConceptScore W1984311902C197934379 @default.
- W1984311902 hasConceptScore W1984311902C2778198053 @default.
- W1984311902 hasConceptScore W1984311902C2778425758 @default.
- W1984311902 hasConceptScore W1984311902C2780521442 @default.
- W1984311902 hasConceptScore W1984311902C500558357 @default.
- W1984311902 hasConceptScore W1984311902C541997718 @default.
- W1984311902 hasConceptScore W1984311902C71924100 @default.
- W1984311902 hasConceptScore W1984311902C84393581 @default.
- W1984311902 hasConceptScore W1984311902C98274493 @default.
- W1984311902 hasLocation W19843119021 @default.
- W1984311902 hasLocation W19843119022 @default.
- W1984311902 hasLocation W19843119023 @default.
- W1984311902 hasLocation W19843119024 @default.
- W1984311902 hasOpenAccess W1984311902 @default.
- W1984311902 hasPrimaryLocation W19843119021 @default.
- W1984311902 hasRelatedWork W1496206578 @default.
- W1984311902 hasRelatedWork W1977361243 @default.
- W1984311902 hasRelatedWork W1983319453 @default.
- W1984311902 hasRelatedWork W1994996727 @default.
- W1984311902 hasRelatedWork W2021538160 @default.
- W1984311902 hasRelatedWork W2031167728 @default.
- W1984311902 hasRelatedWork W2038409672 @default.
- W1984311902 hasRelatedWork W2046798895 @default.
- W1984311902 hasRelatedWork W2064844942 @default.
- W1984311902 hasRelatedWork W2072203541 @default.
- W1984311902 hasRelatedWork W2075715279 @default.
- W1984311902 hasRelatedWork W2089814875 @default.
- W1984311902 hasRelatedWork W2099243893 @default.
- W1984311902 hasRelatedWork W2140333195 @default.
- W1984311902 hasRelatedWork W2145213930 @default.
- W1984311902 hasRelatedWork W2154266385 @default.
- W1984311902 hasRelatedWork W2170122501 @default.
- W1984311902 hasRelatedWork W2216971129 @default.
- W1984311902 hasRelatedWork W2282980925 @default.
- W1984311902 hasRelatedWork W2527327206 @default.
- W1984311902 isParatext "false" @default.
- W1984311902 isRetracted "false" @default.
- W1984311902 magId "1984311902" @default.
- W1984311902 workType "article" @default.