FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984316755> ?p ?o ?g. }

• W1984316755 endingPage "1287" @default.
• W1984316755 startingPage "1279" @default.
• W1984316755 abstract "Mesenchymal stem cells (MSCs) mobilize membrane type-1 matrix metalloproteinase (MT1-MMP) to traffic through both 3-dimensional (3D) collagen as well as basement membrane barriers, but factors capable of regulating the expression and activity of the protease remain unidentified. Herein, we report that the MT1-MMP-dependent invasive activities of rat MSCs are controlled by PDGF-BB. Furthermore, PDGF-BB also stimulates MSC proliferation in 3D type I collagen via an MT1-MMP-dependent process that is linked to pericellular collagen degradation. PDGF-BB stimulates MT1-MMP expression at both the mRNA and protein levels in concert with ERK1/2 and PI3K/AKT activation. Inhibition of ERK1/2 or PI3K/AKT activity potently suppresses both MT1-MMP-dependent invasive and proliferative activities. Basement membrane invasion is likewise stimulated by PDGF-BB in an MT1-MMP-dependent manner via ERK1/2 and PI3K/AKT signaling. Taken together, these data serve to identify PDGF-BB as an important MSC agonist that controls invasive and proliferative activities via MT1-MMP-dependent processes that are regulated by the ERK1/2 and PI3K/AKT signaling pathways." @default.
• W1984316755 created "2016-06-24" @default.
• W1984316755 creator A5066446906 @default.
• W1984316755 creator A5070372668 @default.
• W1984316755 creator A5072793088 @default.
• W1984316755 creator A5082391468 @default.
• W1984316755 creator A5088870232 @default.
• W1984316755 date "2013-05-01" @default.
• W1984316755 modified "2023-10-11" @default.
• W1984316755 title "PDGF-BB-induced MT1-MMP expression regulates proliferation and invasion of mesenchymal stem cells in 3-dimensional collagen via MEK/ERK1/2 and PI3K/AKT signaling" @default.
• W1984316755 cites W1805858026 @default.
• W1984316755 cites W1968505541 @default.
• W1984316755 cites W1975237707 @default.
• W1984316755 cites W1975578801 @default.
• W1984316755 cites W1977803215 @default.
• W1984316755 cites W1979337120 @default.
• W1984316755 cites W1984570894 @default.
• W1984316755 cites W1988894222 @default.
• W1984316755 cites W1993789974 @default.
• W1984316755 cites W1998972215 @default.
• W1984316755 cites W2001582495 @default.
• W1984316755 cites W2005120629 @default.
• W1984316755 cites W2005334224 @default.
• W1984316755 cites W2011234976 @default.
• W1984316755 cites W2012549032 @default.
• W1984316755 cites W2013057349 @default.
• W1984316755 cites W2013398558 @default.
• W1984316755 cites W2027892036 @default.
• W1984316755 cites W2031245565 @default.
• W1984316755 cites W2038218681 @default.
• W1984316755 cites W2054502414 @default.
• W1984316755 cites W2056290881 @default.
• W1984316755 cites W2057143670 @default.
• W1984316755 cites W2062073850 @default.
• W1984316755 cites W2074187493 @default.
• W1984316755 cites W2074669451 @default.
• W1984316755 cites W2076491580 @default.
• W1984316755 cites W2076782790 @default.
• W1984316755 cites W2089839531 @default.
• W1984316755 cites W2091395040 @default.
• W1984316755 cites W2092977624 @default.
• W1984316755 cites W2104468363 @default.
• W1984316755 cites W2106827909 @default.
• W1984316755 cites W2110718459 @default.
• W1984316755 cites W2112976261 @default.
• W1984316755 cites W2115810495 @default.
• W1984316755 cites W2116348485 @default.
• W1984316755 cites W2133395919 @default.
• W1984316755 cites W2134614924 @default.
• W1984316755 cites W2140563259 @default.
• W1984316755 cites W2141592196 @default.
• W1984316755 cites W2141780557 @default.
• W1984316755 cites W2143677869 @default.
• W1984316755 cites W2149479154 @default.
• W1984316755 cites W2150417542 @default.
• W1984316755 cites W2155044423 @default.
• W1984316755 cites W2160761045 @default.
• W1984316755 cites W2162382340 @default.
• W1984316755 cites W2163910782 @default.
• W1984316755 cites W3023410186 @default.
• W1984316755 doi "https://doi.org/10.1016/j.cellsig.2013.01.029" @default.
• W1984316755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23415772" @default.
• W1984316755 hasPublicationYear "2013" @default.
• W1984316755 type Work @default.
• W1984316755 sameAs 1984316755 @default.
• W1984316755 citedByCount "39" @default.
• W1984316755 countsByYear W19843167552014 @default.
• W1984316755 countsByYear W19843167552015 @default.
• W1984316755 countsByYear W19843167552016 @default.
• W1984316755 countsByYear W19843167552017 @default.
• W1984316755 countsByYear W19843167552018 @default.
• W1984316755 countsByYear W19843167552019 @default.
• W1984316755 countsByYear W19843167552020 @default.
• W1984316755 countsByYear W19843167552021 @default.
• W1984316755 countsByYear W19843167552022 @default.
• W1984316755 countsByYear W19843167552023 @default.
• W1984316755 crossrefType "journal-article" @default.
• W1984316755 hasAuthorship W1984316755A5066446906 @default.
• W1984316755 hasAuthorship W1984316755A5070372668 @default.
• W1984316755 hasAuthorship W1984316755A5072793088 @default.
• W1984316755 hasAuthorship W1984316755A5082391468 @default.
• W1984316755 hasAuthorship W1984316755A5088870232 @default.
• W1984316755 hasConcept C109523444 @default.
• W1984316755 hasConcept C170493617 @default.
• W1984316755 hasConcept C180361614 @default.
• W1984316755 hasConcept C185592680 @default.
• W1984316755 hasConcept C198826908 @default.
• W1984316755 hasConcept C2775960820 @default.
• W1984316755 hasConcept C2776193487 @default.
• W1984316755 hasConcept C2776912716 @default.
• W1984316755 hasConcept C502942594 @default.
• W1984316755 hasConcept C55493867 @default.
• W1984316755 hasConcept C62478195 @default.
• W1984316755 hasConcept C75217442 @default.
• W1984316755 hasConcept C86554907 @default.
• W1984316755 hasConcept C86803240 @default.
• W1984316755 hasConcept C95444343 @default.
• W1984316755 hasConceptScore W1984316755C109523444 @default.

• next