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• W1984325186 abstract "Influenza A virus is unique as an RNA virus in that it replicates in the nucleus and undergoes splicing. With only ten major proteins, the virus must gain nuclear access, replicate, assemble progeny virions in the cytoplasm, and then egress. In an effort to elucidate the coordination of these events, we manipulated the transcript levels from the bicistronic nonstructural segment that encodes the spliced virus product responsible for genomic nuclear export. We find that utilization of an erroneous splice site ensures the slow accumulation of the viral nuclear export protein (NEP) while generating excessive levels of an antagonist that inhibits the cellular response to infection. Modulation of this simple transcriptional event results in improperly timed export and loss of virus infection. Together, these data demonstrate that coordination of the influenza A virus life cycle is set by a molecular timer that operates on the inefficient splicing of a virus transcript." @default.
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• W1984325186 date "2013-01-01" @default.
• W1984325186 modified "2023-10-16" @default.
• W1984325186 title "Influenza A Virus Utilizes Suboptimal Splicing to Coordinate the Timing of Infection" @default.
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• W1984325186 doi "https://doi.org/10.1016/j.celrep.2012.12.010" @default.
• W1984325186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3563938" @default.
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