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- W1984325798 abstract "Objective: This study was to investigat the sympathetic and structural remodelings and the relationship between them in different arteries in blood pressure increasing stage. Design and Methods: 12 week-old Spontaneously Hypertensive Rats (SHR) were defined as in blood pressure increasing stage. Age-matched Wistar Kyoto (WKY) rats were as controls. Blood pressure of rats was continuously recorded in conscious unrestrained rats. The sympathetic innervations in thoracic aorta and renal artery were examined with anti-tyrosine hydroxylase (anti-TH) immunohistochemistry methods. Arterial structure, the densities of sympathetic innervations, which included innervation area/ total vascular area (TA) and innervation area/ vascular wall area (WA), together with the area of sympathetic innervation were studied. Results: Compared with that in 12 week-old WKY, External diameter (ED), internal diameter(ID) and total area (TA) were lower, and wall thickness (WT), WT/ID were higher in thoracic aorta of 12 week-old SHR. The areas and densities (both innervation area vs TA and vs WA)of sympathetic innervation in thoracic aorta of 12 week-old SHR were larger than that of WKY (all P < 0.001). And in renal arteries of 12 week-old rats, the areas and densities of sympathetic innervation in SHR were larger than that of WKY but without statistical significance (all P > 0.05). In thoracic aorta, both the area and the density of sympathetic innervation correlated with vascular WT negatively, with ID and WT/ID positively (all P < 0.01). In renal artery, the area of sympathetic innervation correlated with ID, and the density of sympathetic innervation area /TA correlated with WT/ID positively. Conclusions: In blood pressure increasing stage, vascular structural and sympathetic neural remodelings were observed in thoracic aorta and renal artery, there were some relationships among these two remodelings." @default.
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- W1984325798 date "2010-06-01" @default.
- W1984325798 modified "2023-10-18" @default.
- W1984325798 title "NEURAL AND STRUCTURAL REMODELING OF ARTERIES IN SHR: PP.32.267" @default.
- W1984325798 doi "https://doi.org/10.1097/01.hjh.0000379805.59215.d5" @default.
- W1984325798 hasPublicationYear "2010" @default.
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