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- W1984327047 abstract "HLA region contains a set of genes that play crucial roles in the immune system. In addition to the central function of antigen-presentation, which is conducted by HLA class I and II genes, function of the other HLA-linked genes may also contribute to the immune regulation. IKBL, alternatively named as NFKBIL1, mapped within the HLA class III region is a newly emerged gene, of which sequence variations are associated with the susceptibility or resistance to autoimmune and/or inflammatory diseases. We recently have revealed that the IKBL-coded protein, IκBL, is involved in the regulation of alternative splicing in human immune-related genes and a viral gene, which unravel an unexpected function of the HLA-linked gene and provided a novel understanding of HLA in the regulation of immunity and infection. In this review, we summarize the latest trends in the study of IKBL." @default.
- W1984327047 created "2016-06-24" @default.
- W1984327047 creator A5022377956 @default.
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- W1984327047 date "2013-01-01" @default.
- W1984327047 modified "2023-09-27" @default.
- W1984327047 title "IκBL mapped within the HLA region is a novel regulator of alternative splicing involved in the pathogenesis of immune-related diseases" @default.
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- W1984327047 doi "https://doi.org/10.12667/mhc.20.191" @default.
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