Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984329709> ?p ?o ?g. }
- W1984329709 abstract "In France, the rapid scale-up of buprenorphine, an opioid maintenance treatment (OMT), in primary care for drug users has led to an impressive reduction in HIV prevalence among injecting drug users (IDU) but has had no major effect on Hepatitis C incidence. To date, patients willing to start methadone can only do so in a methadone clinic (a medical centre for drug and alcohol dependence (CSAPA) or a hospital setting) and are referred to primary care physicians after dose stabilization. This study aims to assess the effectiveness of methadone in patients who initiated treatment in primary care compared with those who initiated it in a CSAPA, by measuring abstinence from street opioid use after one year of treatment. The ANRS-Methaville study is a randomized multicenter non-inferiority control trial comparing methadone induction (lasting approximately 2 weeks) in primary care and in CSAPA. The model of care chosen for methadone induction in primary care was based on study-specific pre-training of all physicians, exclusion criteria and daily supervision of methadone during the initiation phase. Between January 2009 and January 2011, 10 sites each having one CSAPA and several primary care physicians, were identified to recruit patients to be randomized into two groups, one starting methadone in primary care (n = 147), the other in CSAPA (n = 48). The primary outcome of the study is the proportion of participants abstinent from street opioids after 1 year of treatment i.e. non-inferiority of primary care model in terms of the proportion of patients not using street opioids compared with the proportion observed in those starting methadone in a CSAPA. The ANRS-Methaville study is the first in France to use an interventional trial to improve access to OMT for drug users. Once the non-inferiority results become available, the Ministry of Health and agency for the safety of health products may change the the New Drug Application (NDA) of methadone and make methadone induction by trained primary care physicians possible. The trial is registered with the French Agency of Pharmaceutical Products (AFSSAPS) under the number 2008-A0277-48, the European Union Drug Regulating Authorities Clinical Trials. Number Eudract 2008-001338-28, the ClinicalTrials.gov Identifier: NCT00657397 and the International Standard Randomised Controlled Trial Number Register ISRCTN31125511." @default.
- W1984329709 created "2016-06-24" @default.
- W1984329709 creator A5001055407 @default.
- W1984329709 creator A5015530333 @default.
- W1984329709 creator A5030964299 @default.
- W1984329709 creator A5036757819 @default.
- W1984329709 creator A5050819020 @default.
- W1984329709 creator A5072199399 @default.
- W1984329709 creator A5085208411 @default.
- W1984329709 creator A5087094437 @default.
- W1984329709 creator A5089255872 @default.
- W1984329709 date "2012-06-28" @default.
- W1984329709 modified "2023-09-30" @default.
- W1984329709 title "Methadone induction in primary care (ANRS-Methaville): a phase III randomized intervention trial" @default.
- W1984329709 cites W1499815876 @default.
- W1984329709 cites W1786042234 @default.
- W1984329709 cites W1947374910 @default.
- W1984329709 cites W1965075166 @default.
- W1984329709 cites W1965862609 @default.
- W1984329709 cites W1970237768 @default.
- W1984329709 cites W1970579363 @default.
- W1984329709 cites W1973170627 @default.
- W1984329709 cites W1978761977 @default.
- W1984329709 cites W1982786105 @default.
- W1984329709 cites W1985640063 @default.
- W1984329709 cites W1996710020 @default.
- W1984329709 cites W2004485374 @default.
- W1984329709 cites W2005597355 @default.
- W1984329709 cites W2007847532 @default.
- W1984329709 cites W2023468678 @default.
- W1984329709 cites W2034202363 @default.
- W1984329709 cites W2049232480 @default.
- W1984329709 cites W2049360529 @default.
- W1984329709 cites W2049435742 @default.
- W1984329709 cites W2063573442 @default.
- W1984329709 cites W2068669855 @default.
- W1984329709 cites W2074412169 @default.
- W1984329709 cites W2081183254 @default.
- W1984329709 cites W2086516111 @default.
- W1984329709 cites W2089331124 @default.
- W1984329709 cites W2089398602 @default.
- W1984329709 cites W2096200026 @default.
- W1984329709 cites W2099917845 @default.
- W1984329709 cites W2100628044 @default.
- W1984329709 cites W2108403589 @default.
- W1984329709 cites W2110608362 @default.
- W1984329709 cites W2121538801 @default.
- W1984329709 cites W2130652777 @default.
- W1984329709 cites W2135971353 @default.
- W1984329709 cites W2150115621 @default.
- W1984329709 cites W2158475178 @default.
- W1984329709 cites W2163833666 @default.
- W1984329709 cites W2172151487 @default.
- W1984329709 cites W4245487921 @default.
- W1984329709 doi "https://doi.org/10.1186/1471-2458-12-488" @default.
- W1984329709 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3528472" @default.
- W1984329709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22741944" @default.
- W1984329709 hasPublicationYear "2012" @default.
- W1984329709 type Work @default.
- W1984329709 sameAs 1984329709 @default.
- W1984329709 citedByCount "15" @default.
- W1984329709 countsByYear W19843297092013 @default.
- W1984329709 countsByYear W19843297092014 @default.
- W1984329709 countsByYear W19843297092015 @default.
- W1984329709 countsByYear W19843297092016 @default.
- W1984329709 countsByYear W19843297092017 @default.
- W1984329709 countsByYear W19843297092021 @default.
- W1984329709 crossrefType "journal-article" @default.
- W1984329709 hasAuthorship W1984329709A5001055407 @default.
- W1984329709 hasAuthorship W1984329709A5015530333 @default.
- W1984329709 hasAuthorship W1984329709A5030964299 @default.
- W1984329709 hasAuthorship W1984329709A5036757819 @default.
- W1984329709 hasAuthorship W1984329709A5050819020 @default.
- W1984329709 hasAuthorship W1984329709A5072199399 @default.
- W1984329709 hasAuthorship W1984329709A5085208411 @default.
- W1984329709 hasAuthorship W1984329709A5087094437 @default.
- W1984329709 hasAuthorship W1984329709A5089255872 @default.
- W1984329709 hasBestOaLocation W19843297091 @default.
- W1984329709 hasConcept C118552586 @default.
- W1984329709 hasConcept C126322002 @default.
- W1984329709 hasConcept C168563851 @default.
- W1984329709 hasConcept C170493617 @default.
- W1984329709 hasConcept C194828623 @default.
- W1984329709 hasConcept C2778767360 @default.
- W1984329709 hasConcept C2778903061 @default.
- W1984329709 hasConcept C2778949969 @default.
- W1984329709 hasConcept C2780687700 @default.
- W1984329709 hasConcept C2781063702 @default.
- W1984329709 hasConcept C512399662 @default.
- W1984329709 hasConcept C71924100 @default.
- W1984329709 hasConceptScore W1984329709C118552586 @default.
- W1984329709 hasConceptScore W1984329709C126322002 @default.
- W1984329709 hasConceptScore W1984329709C168563851 @default.
- W1984329709 hasConceptScore W1984329709C170493617 @default.
- W1984329709 hasConceptScore W1984329709C194828623 @default.
- W1984329709 hasConceptScore W1984329709C2778767360 @default.
- W1984329709 hasConceptScore W1984329709C2778903061 @default.
- W1984329709 hasConceptScore W1984329709C2778949969 @default.
- W1984329709 hasConceptScore W1984329709C2780687700 @default.
- W1984329709 hasConceptScore W1984329709C2781063702 @default.