FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984345357> ?p ?o ?g. }

• W1984345357 endingPage "504" @default.
• W1984345357 startingPage "499" @default.
• W1984345357 abstract "Red meat and fiber rich foods are the dietary factors most consistently related to colon carcinogenesis. Although several components in these dietary sources may contribute, the biochemical mechanism by which red meat and fiber affect colorectal carcinogenesis has not yet been established. Sphingomyelin metabolism is a novel signal transduction pathway that may have an impact on colonic tumorigenesis. The present study investigated the activity changes of sphingomyelinase (SMase), ceramidase and caspase-3 in colonic mucosa of rats fed on a high fat control diet, the control diet with beef and the control diet with fiber (cellulose). After a three week feeding period the colonic mucosa were scraped and homogenized and enzyme activities were determined. The fiber diet significantly increased the activities of neutral and acid SMases but had no effect on those of alkaline SMase and neutral ceramidase. The beef diet, on the other hand, significantly reduced neutral ceramidase activity, but had no effect on the activities of any SMase. In addition, the beef diet significantly reduced and the fiber diet increased caspase-3 activity in the colonic mucosa when compared with the control diet. The changes of caspase-3 activities were abolished by preincubating the samples with caspase-3 inhibitor. No significant changes of intestinal alkaline phosphatase could be found among the three dietary groups. In conclusion, fiber and red meat in the high fat diet affected in an opposite way the enzymes responsible for sphingomyelin metabolism and apoptosis in the colon. The effects may have implications in colorectal tumorigenesis." @default.
• W1984345357 created "2016-06-24" @default.
• W1984345357 creator A5010812501 @default.
• W1984345357 creator A5017986169 @default.
• W1984345357 creator A5027562999 @default.
• W1984345357 creator A5077944041 @default.
• W1984345357 date "2002-08-01" @default.
• W1984345357 modified "2023-10-16" @default.
• W1984345357 title "Effects of red meat and fiber in high fat diet on activities of sphingomyelinase, ceramidase and caspase-3 in rat colonic mucosa" @default.
• W1984345357 cites W1508672450 @default.
• W1984345357 cites W1554688619 @default.
• W1984345357 cites W1577946620 @default.
• W1984345357 cites W1775391605 @default.
• W1984345357 cites W1831301545 @default.
• W1984345357 cites W1969349351 @default.
• W1984345357 cites W1970175154 @default.
• W1984345357 cites W1972090215 @default.
• W1984345357 cites W1974620451 @default.
• W1984345357 cites W1985048220 @default.
• W1984345357 cites W1986398106 @default.
• W1984345357 cites W1993686652 @default.
• W1984345357 cites W1994968541 @default.
• W1984345357 cites W199828498 @default.
• W1984345357 cites W1998509719 @default.
• W1984345357 cites W2022407649 @default.
• W1984345357 cites W2028582699 @default.
• W1984345357 cites W2029303498 @default.
• W1984345357 cites W2036292578 @default.
• W1984345357 cites W2066287839 @default.
• W1984345357 cites W2068603376 @default.
• W1984345357 cites W2074555985 @default.
• W1984345357 cites W2087228220 @default.
• W1984345357 cites W2096012158 @default.
• W1984345357 cites W2104521410 @default.
• W1984345357 cites W2112851606 @default.
• W1984345357 cites W2128821991 @default.
• W1984345357 cites W2130807585 @default.
• W1984345357 cites W2138905189 @default.
• W1984345357 cites W2152151955 @default.
• W1984345357 cites W2170510304 @default.
• W1984345357 cites W2220000844 @default.
• W1984345357 cites W2322213171 @default.
• W1984345357 cites W4234468600 @default.
• W1984345357 doi "https://doi.org/10.1016/s0955-2863(02)00191-2" @default.
• W1984345357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12165363" @default.
• W1984345357 hasPublicationYear "2002" @default.
• W1984345357 type Work @default.
• W1984345357 sameAs 1984345357 @default.
• W1984345357 citedByCount "8" @default.
• W1984345357 countsByYear W19843453572015 @default.
• W1984345357 countsByYear W19843453572019 @default.
• W1984345357 crossrefType "journal-article" @default.
• W1984345357 hasAuthorship W1984345357A5010812501 @default.
• W1984345357 hasAuthorship W1984345357A5017986169 @default.
• W1984345357 hasAuthorship W1984345357A5027562999 @default.
• W1984345357 hasAuthorship W1984345357A5077944041 @default.
• W1984345357 hasConcept C126322002 @default.
• W1984345357 hasConcept C134018914 @default.
• W1984345357 hasConcept C160160445 @default.
• W1984345357 hasConcept C181199279 @default.
• W1984345357 hasConcept C185592680 @default.
• W1984345357 hasConcept C190283241 @default.
• W1984345357 hasConcept C2777851122 @default.
• W1984345357 hasConcept C2778163477 @default.
• W1984345357 hasConcept C3019368612 @default.
• W1984345357 hasConcept C31903555 @default.
• W1984345357 hasConcept C55493867 @default.
• W1984345357 hasConcept C61322309 @default.
• W1984345357 hasConcept C61705674 @default.
• W1984345357 hasConcept C71924100 @default.
• W1984345357 hasConcept C86803240 @default.
• W1984345357 hasConceptScore W1984345357C126322002 @default.
• W1984345357 hasConceptScore W1984345357C134018914 @default.
• W1984345357 hasConceptScore W1984345357C160160445 @default.
• W1984345357 hasConceptScore W1984345357C181199279 @default.
• W1984345357 hasConceptScore W1984345357C185592680 @default.
• W1984345357 hasConceptScore W1984345357C190283241 @default.
• W1984345357 hasConceptScore W1984345357C2777851122 @default.
• W1984345357 hasConceptScore W1984345357C2778163477 @default.
• W1984345357 hasConceptScore W1984345357C3019368612 @default.
• W1984345357 hasConceptScore W1984345357C31903555 @default.
• W1984345357 hasConceptScore W1984345357C55493867 @default.
• W1984345357 hasConceptScore W1984345357C61322309 @default.
• W1984345357 hasConceptScore W1984345357C61705674 @default.
• W1984345357 hasConceptScore W1984345357C71924100 @default.
• W1984345357 hasConceptScore W1984345357C86803240 @default.
• W1984345357 hasIssue "8" @default.
• W1984345357 hasLocation W19843453571 @default.
• W1984345357 hasLocation W19843453572 @default.
• W1984345357 hasOpenAccess W1984345357 @default.
• W1984345357 hasPrimaryLocation W19843453571 @default.
• W1984345357 hasRelatedWork W1428714033 @default.
• W1984345357 hasRelatedWork W2037430500 @default.
• W1984345357 hasRelatedWork W2078449710 @default.
• W1984345357 hasRelatedWork W2085982495 @default.
• W1984345357 hasRelatedWork W2130807585 @default.
• W1984345357 hasRelatedWork W2133772801 @default.
• W1984345357 hasRelatedWork W2171355310 @default.

• next