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- W1984356635 abstract "Abstract To optimise the therapeutic effects of the ADEPT approach and to avoid toxicity, it is desirable to reduce plasma enzyme activity after tumour localisation has occured. High levels of enzyme activity in plasma and non-specific retention of conjugate in normal tissues result in prodrug activation at these sites. Reducing plasma enzyme levels also reduces the level of non-specific enzyme retention in normal tissues. This chapter describes some of the strategies that have been developed to accelerate the clearance of antibody-enzyme conjugates from blood after tumour localisation has occured." @default.
- W1984356635 created "2016-06-24" @default.
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- W1984356635 date "1996-12-01" @default.
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- W1984356635 title "Accelerated clearance systems" @default.
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- W1984356635 doi "https://doi.org/10.1016/s0169-409x(96)00441-3" @default.
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