FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984374140> ?p ?o ?g. }

• W1984374140 endingPage "289" @default.
• W1984374140 startingPage "283" @default.
• W1984374140 abstract "Objectives: Anticonvulsants have provided major treatment advances for patients with bipolar disorder. Many of these drugs, including several with proven efficacy in bipolar mania or depression, enhance the activity of the γ‐amino butyric acid (GABA) neurotransmitter system. A new anticonvulsant, tiagabine, has selective GABAergic activity and is approved for patients with partial epilepsy. Few reports of its potential effectiveness in bipolar disorder, however, have been published. We sought to evaluate the effectiveness of tiagabine added to ongoing medication regimens in patients with bipolar disorder inadequately responsive to or intolerant of usual treatments. Methods: Seventeen treatment‐refractory patients participating in the Stanley Foundation Bipolar Network (SFBN) long‐term follow‐up study were offered open treatment with add‐on tiagabine after discussion of the risks, benefits, other treatment options and giving informed consent. Patients’ clinical symptoms and somatic complaints were closely monitored with SFBN longitudinal and cross‐sectional ratings. Four patients discontinued low‐dose tiagabine prior to the second visit and were excluded from data analysis. Results: Thirteen patients received a mean of 38 days of treatment at a mean dose of 8.7 mg/day of tiagabine. On the Clinical Global Impression Scale for Bipolar Disorder Overall category, three (23%) patients showed much or very much improvement and 10 (77%) patients showed no change or worsening. Three significant adverse events were noted, including two presumptive seizures. Conclusions: Open add‐on tiagabine for treatment‐refractory patients with bipolar disorder demonstrated limited efficacy with the majority of patients showing no change or worsening of clinical symptoms. In addition, patients experienced serious side‐effects attributed as likely due to the medication, which resolved without lasting consequence when tiagabine was discontinued." @default.
• W1984374140 created "2016-06-24" @default.
• W1984374140 creator A5006219749 @default.
• W1984374140 creator A5006895356 @default.
• W1984374140 creator A5008103327 @default.
• W1984374140 creator A5009735573 @default.
• W1984374140 creator A5013246959 @default.
• W1984374140 creator A5029433360 @default.
• W1984374140 creator A5053329398 @default.
• W1984374140 creator A5054719819 @default.
• W1984374140 creator A5062215530 @default.
• W1984374140 creator A5071789331 @default.
• W1984374140 creator A5079329164 @default.
• W1984374140 creator A5081124023 @default.
• W1984374140 creator A5090875089 @default.
• W1984374140 date "2002-09-25" @default.
• W1984374140 modified "2023-10-18" @default.
• W1984374140 title "Tiagabine in treatment refractory bipolar disorder: a clinical case series" @default.
• W1984374140 cites W1968700646 @default.
• W1984374140 cites W1974164830 @default.
• W1984374140 cites W1974585730 @default.
• W1984374140 cites W1980812622 @default.
• W1984374140 cites W1983927699 @default.
• W1984374140 cites W1999160102 @default.
• W1984374140 cites W1999692103 @default.
• W1984374140 cites W2000053835 @default.
• W1984374140 cites W2003629147 @default.
• W1984374140 cites W2020541526 @default.
• W1984374140 cites W2030034545 @default.
• W1984374140 cites W2035271231 @default.
• W1984374140 cites W2037231243 @default.
• W1984374140 cites W2060087267 @default.
• W1984374140 cites W2065174084 @default.
• W1984374140 cites W2067249871 @default.
• W1984374140 cites W2115120433 @default.
• W1984374140 cites W2127124395 @default.
• W1984374140 cites W2130944577 @default.
• W1984374140 cites W2158303290 @default.
• W1984374140 cites W2163610533 @default.
• W1984374140 cites W2167659819 @default.
• W1984374140 cites W2237643278 @default.
• W1984374140 cites W2627728 @default.
• W1984374140 cites W2827060853 @default.
• W1984374140 cites W4254976833 @default.
• W1984374140 cites W4299498581 @default.
• W1984374140 doi "https://doi.org/10.1034/j.1399-5618.2002.01201.x" @default.
• W1984374140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12479659" @default.
• W1984374140 hasPublicationYear "2002" @default.
• W1984374140 type Work @default.
• W1984374140 sameAs 1984374140 @default.
• W1984374140 citedByCount "63" @default.
• W1984374140 countsByYear W19843741402012 @default.
• W1984374140 countsByYear W19843741402013 @default.
• W1984374140 countsByYear W19843741402016 @default.
• W1984374140 countsByYear W19843741402018 @default.
• W1984374140 countsByYear W19843741402019 @default.
• W1984374140 countsByYear W19843741402021 @default.
• W1984374140 countsByYear W19843741402023 @default.
• W1984374140 crossrefType "journal-article" @default.
• W1984374140 hasAuthorship W1984374140A5006219749 @default.
• W1984374140 hasAuthorship W1984374140A5006895356 @default.
• W1984374140 hasAuthorship W1984374140A5008103327 @default.
• W1984374140 hasAuthorship W1984374140A5009735573 @default.
• W1984374140 hasAuthorship W1984374140A5013246959 @default.
• W1984374140 hasAuthorship W1984374140A5029433360 @default.
• W1984374140 hasAuthorship W1984374140A5053329398 @default.
• W1984374140 hasAuthorship W1984374140A5054719819 @default.
• W1984374140 hasAuthorship W1984374140A5062215530 @default.
• W1984374140 hasAuthorship W1984374140A5071789331 @default.
• W1984374140 hasAuthorship W1984374140A5079329164 @default.
• W1984374140 hasAuthorship W1984374140A5081124023 @default.
• W1984374140 hasAuthorship W1984374140A5090875089 @default.
• W1984374140 hasConcept C118552586 @default.
• W1984374140 hasConcept C121332964 @default.
• W1984374140 hasConcept C126322002 @default.
• W1984374140 hasConcept C142424586 @default.
• W1984374140 hasConcept C15744967 @default.
• W1984374140 hasConcept C187212893 @default.
• W1984374140 hasConcept C2775858608 @default.
• W1984374140 hasConcept C2776174506 @default.
• W1984374140 hasConcept C2776749334 @default.
• W1984374140 hasConcept C2776809841 @default.
• W1984374140 hasConcept C2778186239 @default.
• W1984374140 hasConcept C2778541603 @default.
• W1984374140 hasConcept C42219234 @default.
• W1984374140 hasConcept C71924100 @default.
• W1984374140 hasConcept C87355193 @default.
• W1984374140 hasConceptScore W1984374140C118552586 @default.
• W1984374140 hasConceptScore W1984374140C121332964 @default.
• W1984374140 hasConceptScore W1984374140C126322002 @default.
• W1984374140 hasConceptScore W1984374140C142424586 @default.
• W1984374140 hasConceptScore W1984374140C15744967 @default.
• W1984374140 hasConceptScore W1984374140C187212893 @default.
• W1984374140 hasConceptScore W1984374140C2775858608 @default.
• W1984374140 hasConceptScore W1984374140C2776174506 @default.
• W1984374140 hasConceptScore W1984374140C2776749334 @default.
• W1984374140 hasConceptScore W1984374140C2776809841 @default.
• W1984374140 hasConceptScore W1984374140C2778186239 @default.

• next