Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984391549> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1984391549 abstract "Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DCBi-specific antibodies are suggested to possess unique advantages when compared with mono-specific antibodies as anti-cancer therapeutics. These advantages include greater efficacy, superior combination with standard of care agents, and evasion of resistance mechanisms. Data are presented supporting the hypothesis that the increased avidity of a tetravalent (non BiTE-like) bi-specific antibody mediates such advantages when compared with conventional bi-valent mono-specific antibodies. Experiments include functional comparisons of antibodies binding the Epidermal Growth Factor (EGFR) and the Insulin-like Growth Factor 1 Receptor (IGF1R) at the biochemical, cellular and tumor xenograft levels. These data support the ongoing use of multi-specific antibodies in oncology research and describe a mechanism that may contribute to superior activity compared to mono-specific antibodies and drug combinations. It is noted that advantages of bi-specific antibody formats remain to be seen clinically in terms of both efficacy and safety.Citation Format: Kris F. Sachsenmeier, Nazzareno Dimasi, Qihui Huang, Erin Sult, Binyam Bezabeh, Ryan Fleming, Carl Hay, Helen Zhong, Shannon Breen, Changshou Gao, Balaji Agoram, Lutz Jermutus, Robert Hollingsworth. The avidity hypothesis: comparing bispecific and monospecific antibodies in preclinical oncology models. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4635. doi:10.1158/1538-7445.AM2013-4635" @default.
- W1984391549 created "2016-06-24" @default.
- W1984391549 creator A5005006676 @default.
- W1984391549 creator A5035878833 @default.
- W1984391549 creator A5040979655 @default.
- W1984391549 creator A5042483704 @default.
- W1984391549 creator A5044514961 @default.
- W1984391549 creator A5044997582 @default.
- W1984391549 creator A5048496451 @default.
- W1984391549 creator A5058012465 @default.
- W1984391549 creator A5064110519 @default.
- W1984391549 creator A5076501775 @default.
- W1984391549 creator A5078061615 @default.
- W1984391549 creator A5083732009 @default.
- W1984391549 creator A5087819473 @default.
- W1984391549 date "2013-04-15" @default.
- W1984391549 modified "2023-09-25" @default.
- W1984391549 title "Abstract 4635: The avidity hypothesis: comparing bispecific and monospecific antibodies in preclinical oncology models." @default.
- W1984391549 doi "https://doi.org/10.1158/1538-7445.am2013-4635" @default.
- W1984391549 hasPublicationYear "2013" @default.
- W1984391549 type Work @default.
- W1984391549 sameAs 1984391549 @default.
- W1984391549 citedByCount "0" @default.
- W1984391549 crossrefType "proceedings-article" @default.
- W1984391549 hasAuthorship W1984391549A5005006676 @default.
- W1984391549 hasAuthorship W1984391549A5035878833 @default.
- W1984391549 hasAuthorship W1984391549A5040979655 @default.
- W1984391549 hasAuthorship W1984391549A5042483704 @default.
- W1984391549 hasAuthorship W1984391549A5044514961 @default.
- W1984391549 hasAuthorship W1984391549A5044997582 @default.
- W1984391549 hasAuthorship W1984391549A5048496451 @default.
- W1984391549 hasAuthorship W1984391549A5058012465 @default.
- W1984391549 hasAuthorship W1984391549A5064110519 @default.
- W1984391549 hasAuthorship W1984391549A5076501775 @default.
- W1984391549 hasAuthorship W1984391549A5078061615 @default.
- W1984391549 hasAuthorship W1984391549A5083732009 @default.
- W1984391549 hasAuthorship W1984391549A5087819473 @default.
- W1984391549 hasConcept C121608353 @default.
- W1984391549 hasConcept C126322002 @default.
- W1984391549 hasConcept C143998085 @default.
- W1984391549 hasConcept C159654299 @default.
- W1984391549 hasConcept C179223381 @default.
- W1984391549 hasConcept C203014093 @default.
- W1984391549 hasConcept C3020495827 @default.
- W1984391549 hasConcept C502942594 @default.
- W1984391549 hasConcept C542903549 @default.
- W1984391549 hasConcept C71924100 @default.
- W1984391549 hasConceptScore W1984391549C121608353 @default.
- W1984391549 hasConceptScore W1984391549C126322002 @default.
- W1984391549 hasConceptScore W1984391549C143998085 @default.
- W1984391549 hasConceptScore W1984391549C159654299 @default.
- W1984391549 hasConceptScore W1984391549C179223381 @default.
- W1984391549 hasConceptScore W1984391549C203014093 @default.
- W1984391549 hasConceptScore W1984391549C3020495827 @default.
- W1984391549 hasConceptScore W1984391549C502942594 @default.
- W1984391549 hasConceptScore W1984391549C542903549 @default.
- W1984391549 hasConceptScore W1984391549C71924100 @default.
- W1984391549 hasLocation W19843915491 @default.
- W1984391549 hasOpenAccess W1984391549 @default.
- W1984391549 hasPrimaryLocation W19843915491 @default.
- W1984391549 hasRelatedWork W1537191383 @default.
- W1984391549 hasRelatedWork W1972089838 @default.
- W1984391549 hasRelatedWork W1978368856 @default.
- W1984391549 hasRelatedWork W1981730803 @default.
- W1984391549 hasRelatedWork W2003244776 @default.
- W1984391549 hasRelatedWork W2011219467 @default.
- W1984391549 hasRelatedWork W2036598838 @default.
- W1984391549 hasRelatedWork W2063462089 @default.
- W1984391549 hasRelatedWork W2068482302 @default.
- W1984391549 hasRelatedWork W2108585358 @default.
- W1984391549 hasRelatedWork W2139998450 @default.
- W1984391549 hasRelatedWork W2140167069 @default.
- W1984391549 hasRelatedWork W2168109319 @default.
- W1984391549 hasRelatedWork W2325051593 @default.
- W1984391549 hasRelatedWork W2564362027 @default.
- W1984391549 hasRelatedWork W2885234299 @default.
- W1984391549 hasRelatedWork W2994086405 @default.
- W1984391549 hasRelatedWork W3037017724 @default.
- W1984391549 hasRelatedWork W3083708532 @default.
- W1984391549 hasRelatedWork W3098060231 @default.
- W1984391549 isParatext "false" @default.
- W1984391549 isRetracted "false" @default.
- W1984391549 magId "1984391549" @default.
- W1984391549 workType "article" @default.