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• W1984409894 abstract "Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H2S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H2S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H2S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H2S-production and may aid in the anti-angiogenic state." @default.
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• W1984409894 date "2012-06-01" @default.
• W1984409894 modified "2023-09-30" @default.
• W1984409894 title "Hydrogen sulfide producing enzymes in pregnancy and preeclampsia" @default.
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• W1984409894 doi "https://doi.org/10.1016/j.placenta.2012.02.014" @default.
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