Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984410492> ?p ?o ?g. }
- W1984410492 endingPage "516" @default.
- W1984410492 startingPage "508" @default.
- W1984410492 abstract "Gene deletion experiments have shown that the three TGFβ isoforms regulate distinct developmental processes. Recent work by our group and others showed that the integrins αvβ6 and αvβ8 activate latent forms of TGFβ1 and TGFβ3. This raises the possibility that TGFβ1 and TGFβ3 act redundantly in developmental processes where both isoforms are expressed and activation is by integrins. To investigate this issue, we generated mice with defective integrin-mediated TGFβ1 activation (Tgfb1RGE/RGE) that were also homozygous for a null mutation in the TGFβ3 gene. Tgfb1RGE/RGE; Tgfb3−/− mice have severely perturbed development of the brain vasculature that is highly similar to that in mice lacking αvβ8. Some Tgfb1RGE/RGE; Tgfb3+/− and Tgfb1RGE/RGE; Tgfb3+/+ mice have milder, background-dependent versions of the phenotype. In addition, we found that Tgfb3 gene status influences embryonic lethality due to TGFβ1 deficiency after limited backcrossing to the BALB/c background. Conversely, Tgfb1 gene status modifies the extent of palate fusion in Tgfb3−/− mice after limited backcrossing to the ICR background. Our results are consistent with a functional connection between TGFβ1 and TGFβ3 during development based on a shared mechanism of activation." @default.
- W1984410492 created "2016-06-24" @default.
- W1984410492 creator A5024082250 @default.
- W1984410492 creator A5040600525 @default.
- W1984410492 creator A5044713082 @default.
- W1984410492 creator A5084801889 @default.
- W1984410492 creator A5086912994 @default.
- W1984410492 date "2008-05-01" @default.
- W1984410492 modified "2023-10-11" @default.
- W1984410492 title "TGFβ1 and TGFβ3 are partially redundant effectors in brain vascular morphogenesis" @default.
- W1984410492 cites W111650051 @default.
- W1984410492 cites W1479951257 @default.
- W1984410492 cites W1564833623 @default.
- W1984410492 cites W1575754639 @default.
- W1984410492 cites W1582963778 @default.
- W1984410492 cites W1595810968 @default.
- W1984410492 cites W1858922792 @default.
- W1984410492 cites W1905978178 @default.
- W1984410492 cites W1931073059 @default.
- W1984410492 cites W1964513396 @default.
- W1984410492 cites W1973405552 @default.
- W1984410492 cites W1975522586 @default.
- W1984410492 cites W1976275689 @default.
- W1984410492 cites W1981736075 @default.
- W1984410492 cites W1987589505 @default.
- W1984410492 cites W1998975199 @default.
- W1984410492 cites W2006264351 @default.
- W1984410492 cites W2012678527 @default.
- W1984410492 cites W2013445858 @default.
- W1984410492 cites W2016576487 @default.
- W1984410492 cites W2018685438 @default.
- W1984410492 cites W2018822666 @default.
- W1984410492 cites W2022415270 @default.
- W1984410492 cites W2028892293 @default.
- W1984410492 cites W2032196626 @default.
- W1984410492 cites W2035183569 @default.
- W1984410492 cites W2039317622 @default.
- W1984410492 cites W2044069347 @default.
- W1984410492 cites W2054797017 @default.
- W1984410492 cites W2059380389 @default.
- W1984410492 cites W2060372234 @default.
- W1984410492 cites W2064050439 @default.
- W1984410492 cites W2064113953 @default.
- W1984410492 cites W2075998623 @default.
- W1984410492 cites W2079517510 @default.
- W1984410492 cites W2081451346 @default.
- W1984410492 cites W2093254736 @default.
- W1984410492 cites W2094165314 @default.
- W1984410492 cites W2101314011 @default.
- W1984410492 cites W2108280128 @default.
- W1984410492 cites W2108668719 @default.
- W1984410492 cites W2114505861 @default.
- W1984410492 cites W2126164549 @default.
- W1984410492 cites W2157116635 @default.
- W1984410492 cites W2159072111 @default.
- W1984410492 cites W2163220652 @default.
- W1984410492 cites W2163504684 @default.
- W1984410492 cites W2168558463 @default.
- W1984410492 cites W2329694887 @default.
- W1984410492 cites W2331249819 @default.
- W1984410492 doi "https://doi.org/10.1016/j.mod.2008.01.003" @default.
- W1984410492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18343643" @default.
- W1984410492 hasPublicationYear "2008" @default.
- W1984410492 type Work @default.
- W1984410492 sameAs 1984410492 @default.
- W1984410492 citedByCount "58" @default.
- W1984410492 countsByYear W19844104922012 @default.
- W1984410492 countsByYear W19844104922013 @default.
- W1984410492 countsByYear W19844104922014 @default.
- W1984410492 countsByYear W19844104922015 @default.
- W1984410492 countsByYear W19844104922016 @default.
- W1984410492 countsByYear W19844104922017 @default.
- W1984410492 countsByYear W19844104922018 @default.
- W1984410492 countsByYear W19844104922020 @default.
- W1984410492 countsByYear W19844104922021 @default.
- W1984410492 countsByYear W19844104922022 @default.
- W1984410492 crossrefType "journal-article" @default.
- W1984410492 hasAuthorship W1984410492A5024082250 @default.
- W1984410492 hasAuthorship W1984410492A5040600525 @default.
- W1984410492 hasAuthorship W1984410492A5044713082 @default.
- W1984410492 hasAuthorship W1984410492A5084801889 @default.
- W1984410492 hasAuthorship W1984410492A5086912994 @default.
- W1984410492 hasBestOaLocation W19844104921 @default.
- W1984410492 hasConcept C10205521 @default.
- W1984410492 hasConcept C104317684 @default.
- W1984410492 hasConcept C118131993 @default.
- W1984410492 hasConcept C127716648 @default.
- W1984410492 hasConcept C153911025 @default.
- W1984410492 hasConcept C170493617 @default.
- W1984410492 hasConcept C195687474 @default.
- W1984410492 hasConcept C2778229498 @default.
- W1984410492 hasConcept C28328180 @default.
- W1984410492 hasConcept C53345823 @default.
- W1984410492 hasConcept C54355233 @default.
- W1984410492 hasConcept C6061869 @default.
- W1984410492 hasConcept C86803240 @default.
- W1984410492 hasConcept C95444343 @default.
- W1984410492 hasConceptScore W1984410492C10205521 @default.