FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984415511> ?p ?o ?g. }

• W1984415511 endingPage "9103" @default.
• W1984415511 startingPage "9096" @default.
• W1984415511 abstract "The crystal structure of the dimeric steroid metabolizing enzyme, delta 5-3-ketosteroid isomerase (EC 5.3.3.1), has been solved to 6-A resolution by multiple isomorphous replacement, augmented by real space direct methods. The unit cell is hexagonal (space group P6122) with dimensions a = b = 65.4 A, c = 504 A, and contains four identical 13,400-dalton protomers in each of its 12 asymmetric units. The 504-A c axis required double focusing mirrors (Franks optics) to resolve the reflections. The complexity of the combined local and lattice symmetry necessitated direct methods to establish the positions of heavy atoms in even the simplest of the isomorphous derivatives. The electron density map clearly showed both (a) the elaborate packing scheme of protomers, which accounts for this large and complicated unit cell, and (b) the coarse features of the functional dimer. The steroid-binding site has been established by imaging the bound inhibitor, 4-acetoxymercuriestradiol, in a difference Fourier map. Each of the dimer's two steroid-binding sites lies completely within one subunit but close enough to the opposing subunit that functional interactions may be possible." @default.
• W1984415511 created "2016-06-24" @default.
• W1984415511 creator A5010562034 @default.
• W1984415511 creator A5028174616 @default.
• W1984415511 creator A5059655185 @default.
• W1984415511 date "1984-07-01" @default.
• W1984415511 modified "2023-09-27" @default.
• W1984415511 title "The 6-A crystal structure of delta 5-3-ketosteroid isomerase. Architecture and location of the active center." @default.
• W1984415511 cites W117087672 @default.
• W1984415511 cites W1536092884 @default.
• W1984415511 cites W1545273247 @default.
• W1984415511 cites W1548665972 @default.
• W1984415511 cites W1583016962 @default.
• W1984415511 cites W1607294005 @default.
• W1984415511 cites W1970208847 @default.
• W1984415511 cites W1972740533 @default.
• W1984415511 cites W1973142362 @default.
• W1984415511 cites W1975746124 @default.
• W1984415511 cites W1976553017 @default.
• W1984415511 cites W1984412128 @default.
• W1984415511 cites W1986385534 @default.
• W1984415511 cites W1986838114 @default.
• W1984415511 cites W1993890638 @default.
• W1984415511 cites W2004054583 @default.
• W1984415511 cites W2005642529 @default.
• W1984415511 cites W2009506777 @default.
• W1984415511 cites W2011912423 @default.
• W1984415511 cites W2012611984 @default.
• W1984415511 cites W2013894810 @default.
• W1984415511 cites W2013944709 @default.
• W1984415511 cites W2014606467 @default.
• W1984415511 cites W2015056405 @default.
• W1984415511 cites W2015747945 @default.
• W1984415511 cites W2018170817 @default.
• W1984415511 cites W2019095525 @default.
• W1984415511 cites W2026116203 @default.
• W1984415511 cites W2042253812 @default.
• W1984415511 cites W2043417110 @default.
• W1984415511 cites W2052772948 @default.
• W1984415511 cites W2053246850 @default.
• W1984415511 cites W2060534633 @default.
• W1984415511 cites W2061252795 @default.
• W1984415511 cites W2062586033 @default.
• W1984415511 cites W2067853772 @default.
• W1984415511 cites W2069743850 @default.
• W1984415511 cites W2070340378 @default.
• W1984415511 cites W2072717679 @default.
• W1984415511 cites W2073091642 @default.
• W1984415511 cites W2074049284 @default.
• W1984415511 cites W2074786454 @default.
• W1984415511 cites W2091585311 @default.
• W1984415511 cites W2101930899 @default.
• W1984415511 cites W2102239327 @default.
• W1984415511 cites W2107550339 @default.
• W1984415511 cites W2137898734 @default.
• W1984415511 cites W2140787958 @default.
• W1984415511 cites W2142635507 @default.
• W1984415511 cites W2156589998 @default.
• W1984415511 cites W2313139928 @default.
• W1984415511 cites W2985636467 @default.
• W1984415511 doi "https://doi.org/10.1016/s0021-9258(17)47270-x" @default.
• W1984415511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6746641" @default.
• W1984415511 hasPublicationYear "1984" @default.
• W1984415511 type Work @default.
• W1984415511 sameAs 1984415511 @default.
• W1984415511 citedByCount "38" @default.
• W1984415511 countsByYear W19844155112016 @default.
• W1984415511 countsByYear W19844155112019 @default.
• W1984415511 crossrefType "journal-article" @default.
• W1984415511 hasAuthorship W1984415511A5010562034 @default.
• W1984415511 hasAuthorship W1984415511A5028174616 @default.
• W1984415511 hasAuthorship W1984415511A5059655185 @default.
• W1984415511 hasBestOaLocation W19844155111 @default.
• W1984415511 hasConcept C115624301 @default.
• W1984415511 hasConcept C123657996 @default.
• W1984415511 hasConcept C166957645 @default.
• W1984415511 hasConcept C181199279 @default.
• W1984415511 hasConcept C185592680 @default.
• W1984415511 hasConcept C205649164 @default.
• W1984415511 hasConcept C2778257825 @default.
• W1984415511 hasConcept C2778861492 @default.
• W1984415511 hasConcept C2779463800 @default.
• W1984415511 hasConcept C2781264208 @default.
• W1984415511 hasConcept C55493867 @default.
• W1984415511 hasConcept C71240020 @default.
• W1984415511 hasConcept C8010536 @default.
• W1984415511 hasConceptScore W1984415511C115624301 @default.
• W1984415511 hasConceptScore W1984415511C123657996 @default.
• W1984415511 hasConceptScore W1984415511C166957645 @default.
• W1984415511 hasConceptScore W1984415511C181199279 @default.
• W1984415511 hasConceptScore W1984415511C185592680 @default.
• W1984415511 hasConceptScore W1984415511C205649164 @default.
• W1984415511 hasConceptScore W1984415511C2778257825 @default.
• W1984415511 hasConceptScore W1984415511C2778861492 @default.
• W1984415511 hasConceptScore W1984415511C2779463800 @default.
• W1984415511 hasConceptScore W1984415511C2781264208 @default.
• W1984415511 hasConceptScore W1984415511C55493867 @default.
• W1984415511 hasConceptScore W1984415511C71240020 @default.

• next