FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1984418618> ?p ?o ?g. }

• W1984418618 endingPage "15685" @default.
• W1984418618 startingPage "15677" @default.
• W1984418618 abstract "Alzheimer's disease (AD) is an age-related neurodegenerative disease and the most common form of dementia. AD is pathologically characterized by the deposition of pathogenic Aβ peptides that are derived from larger integral membrane proteins, termed β-amyloid precursor proteins (APPs). In an attempt to understand the function of APP, in vitro studies have focused on the identification of interacting proteins. To investigate the APP in vivo interactome in an unbiased manner, we generated mice that harbor a mouse prion protein promoter-driven cDNA encoding human APP-695 fused to a C-terminal affinity tag. Using this tag, we prepared mild detergent lysates from transgenic mouse brain cortical membrane preparations and isolated a number of previously identified APP-interacting proteins. In addition to these factors, mass spectrometric analysis revealed the presence of NEEP21 as a novel interacting protein. We now report that NEEP21 profoundly affects the processing of APP and Aβ production. Thus, this study demonstrates that using proteomic methods on our transgenic model can uncover important in vivo APP-interacting proteins that will provide insights into the biology of APP." @default.
• W1984418618 created "2016-06-24" @default.
• W1984418618 creator A5010416927 @default.
• W1984418618 creator A5024978593 @default.
• W1984418618 creator A5050004777 @default.
• W1984418618 creator A5076252609 @default.
• W1984418618 date "2010-11-17" @default.
• W1984418618 modified "2023-09-27" @default.
• W1984418618 title "Identification of NEEP21 as a β-Amyloid Precursor Protein-Interacting Protein<i>In Vivo</i>That Modulates Amyloidogenic Processing<i>In Vitro</i>" @default.
• W1984418618 cites W1574959285 @default.
• W1984418618 cites W1599007193 @default.
• W1984418618 cites W1783111952 @default.
• W1984418618 cites W1955491145 @default.
• W1984418618 cites W1964314802 @default.
• W1984418618 cites W1969810313 @default.
• W1984418618 cites W1975821930 @default.
• W1984418618 cites W1979240613 @default.
• W1984418618 cites W1984930425 @default.
• W1984418618 cites W1991366673 @default.
• W1984418618 cites W1998446208 @default.
• W1984418618 cites W1999977743 @default.
• W1984418618 cites W2001914338 @default.
• W1984418618 cites W2002025388 @default.
• W1984418618 cites W2014739744 @default.
• W1984418618 cites W2019696636 @default.
• W1984418618 cites W2022171792 @default.
• W1984418618 cites W2024879932 @default.
• W1984418618 cites W2025563134 @default.
• W1984418618 cites W2038783205 @default.
• W1984418618 cites W2039750814 @default.
• W1984418618 cites W2042089915 @default.
• W1984418618 cites W2048558199 @default.
• W1984418618 cites W2050673616 @default.
• W1984418618 cites W2050679485 @default.
• W1984418618 cites W2051515210 @default.
• W1984418618 cites W2051646172 @default.
• W1984418618 cites W2051795211 @default.
• W1984418618 cites W2054615702 @default.
• W1984418618 cites W2056913569 @default.
• W1984418618 cites W2057712792 @default.
• W1984418618 cites W2058908104 @default.
• W1984418618 cites W2064331567 @default.
• W1984418618 cites W2067445072 @default.
• W1984418618 cites W2068600128 @default.
• W1984418618 cites W2069270527 @default.
• W1984418618 cites W2071691905 @default.
• W1984418618 cites W2079291061 @default.
• W1984418618 cites W2082438248 @default.
• W1984418618 cites W2089703116 @default.
• W1984418618 cites W2090150925 @default.
• W1984418618 cites W2091835577 @default.
• W1984418618 cites W2098003280 @default.
• W1984418618 cites W2099667797 @default.
• W1984418618 cites W2108649886 @default.
• W1984418618 cites W2123591482 @default.
• W1984418618 cites W2132695172 @default.
• W1984418618 cites W2155290272 @default.
• W1984418618 cites W2161442189 @default.
• W1984418618 cites W2168801997 @default.
• W1984418618 cites W4248632800 @default.
• W1984418618 doi "https://doi.org/10.1523/jneurosci.4464-10.2010" @default.
• W1984418618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3104400" @default.
• W1984418618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21084623" @default.
• W1984418618 hasPublicationYear "2010" @default.
• W1984418618 type Work @default.
• W1984418618 sameAs 1984418618 @default.
• W1984418618 citedByCount "53" @default.
• W1984418618 countsByYear W19844186182012 @default.
• W1984418618 countsByYear W19844186182013 @default.
• W1984418618 countsByYear W19844186182014 @default.
• W1984418618 countsByYear W19844186182015 @default.
• W1984418618 countsByYear W19844186182016 @default.
• W1984418618 countsByYear W19844186182017 @default.
• W1984418618 countsByYear W19844186182018 @default.
• W1984418618 countsByYear W19844186182019 @default.
• W1984418618 countsByYear W19844186182020 @default.
• W1984418618 countsByYear W19844186182021 @default.
• W1984418618 countsByYear W19844186182022 @default.
• W1984418618 countsByYear W19844186182023 @default.
• W1984418618 crossrefType "journal-article" @default.
• W1984418618 hasAuthorship W1984418618A5010416927 @default.
• W1984418618 hasAuthorship W1984418618A5024978593 @default.
• W1984418618 hasAuthorship W1984418618A5050004777 @default.
• W1984418618 hasAuthorship W1984418618A5076252609 @default.
• W1984418618 hasBestOaLocation W19844186181 @default.
• W1984418618 hasConcept C102230213 @default.
• W1984418618 hasConcept C104317684 @default.
• W1984418618 hasConcept C141035611 @default.
• W1984418618 hasConcept C142724271 @default.
• W1984418618 hasConcept C144647389 @default.
• W1984418618 hasConcept C153911025 @default.
• W1984418618 hasConcept C177907266 @default.
• W1984418618 hasConcept C185592680 @default.
• W1984418618 hasConcept C202751555 @default.
• W1984418618 hasConcept C207001950 @default.
• W1984418618 hasConcept C2777633098 @default.
• W1984418618 hasConcept C2779134260 @default.
• W1984418618 hasConcept C31705614 @default.

• next